2. Metabolic Enzyme/Protease NF-κB
  3. MALT1 NF-κB MMP
  4. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone

Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone is an irreversible MALT1 protein inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression.

For research use only. We do not sell to patients.

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Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone

Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone Chemical Structure

CAS No. : 1926163-57-6

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Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone Related Antibodies

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Description

Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone is an irreversible MALT1 protein inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression[1][2].

IC50 & Target

MALT1[1]
In Vitro

Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone (Compound Z-VRPR-FMK) (50 μM, 24 h) can effectively reduce the level of c-REL in the nucleus of HBL-1 cells and inhibit the signal transduction of NF-κB[2].
Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone (50 μM, 48 h) can inhibit the proliferation of ABC-DLBCL cell lines HBL-1, TMD8, OCI-Ly3 and OCI-Ly10[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone Related Antibodies
Molecular Weight

676.78

Formula

C31H49FN10O6
CAS No.
Sequence

Z-Val-Arg-Pro-{DL-Arg}-{Fluoromethylketone}
Sequence Shortening

Z-VRP-{DL-Arg}-{Fluoromethylketone}
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone1926163-57-6MALT1NF-κBMMPmucosa associated lymphoid tissue lymphoma translocation gene 1Nuclear factor-κBNuclear factor-kappaBMatrix metalloproteinasesanticancerOCI-LY10 cellsproliferationmigrationP65DLBCLInhibitorinhibitorinhibit

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