1926163-57-6
1926163-57-6
Chemical Structure
Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone
- CAS No.: 1926163-57-6
- Formula:C31H49FN10O6
- Molecular Weight:676.78
InChIKey: DYQKGOBRZWMAHV-YTJMMMLMSA-N
SMILES: O=C(OCC1=CC=CC=C1)N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(NC(C(CF)=O)CCCNC(N)=N)=O)=O)=O
Biological Activity: Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone is an irreversible MALT1 protein inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression[1][2].
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Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone | Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone is an irreversible MALT1 protein inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression. | |||||||||||||||||||||
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References
- [1]. Feng J, et al. Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1. Int J Clin Exp Pathol. 2019 Jun 1;12(6):1947-1955. [Content Brief]
- [2]. Lorena Fontan, et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012 Dec 11;22(6):812-24. [Content Brief]
