2. Anti-infection
  3. Bacterial
  4. MA220607

MA220607 is a FtsZ protein inhibitor with activity against both Gram-positive and Gram-negative bacteria. MA220607 inhibits bacterial growth and shows low bacterial resistance frequency. MA220607 increases bacterial membrane permeability and alters proton gradients. MA220607 blocks the formation of bacterial biofilms. MA220607 can be used in studies of bacterial infections.

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MA220607

MA220607 Chemical Structure

CAS No. : 2922826-56-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
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Based on 1 publication(s) in Google Scholar

MA220607 Related Antibodies

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Description

MA220607 is a FtsZ protein inhibitor with activity against both Gram-positive and Gram-negative bacteria. MA220607 inhibits bacterial growth and shows low bacterial resistance frequency. MA220607 increases bacterial membrane permeability and alters proton gradients. MA220607 blocks the formation of bacterial biofilms. MA220607 can be used in studies of bacterial infections[1].

In Vitro

MA220607 exhibits potent broad-spectrum antibacterial activity against both sensitive and drug-resistant Gram-positive strains (MIC = 0.062-2 μg/mL) and Gram-negative strains (MIC = 0.5-4 μg/mL)[1].
MA220607 exhibits bactericidal activity against susceptible S. aureus ATCC25923, Methicillin (HY-121544)-resistant S. aureus ATCC43300, B. subtilis ATCC9372, clinically isolated S. aureus, and A. baumannii ATCC19606, with an MBC/MIC ratio ranging from 2 to 4[1].
MA220607 (0-1 μg/mL; 0-24 h) exerts a concentration-dependent bactericidal effect against S. aureus ATCC25923 and inhibits biofilm formation[1].
MA220607 (2.5-10 μg/mL; 30 min) stimulates the polymerization of purified BsFtsZ protein in a concentration-dependent manner[1].
MA220607 (1 μg/mL) disrupts the membrane integrity of S. aureus ATCC25923, thereby causing leakage of intracellular contents[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MA220607 Related Antibodies
In Vivo

MA220607 (5-25 mg/kg; i.p.; single administration) exhibits potent in vivo efficacy against Staphylococcus aureus ATCC25923-induced murine bacteremia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice (male, average body mass 30 g)[1]
Dosage: 5 mg/kg; 25 mg/kg
Administration: i.p.; single dose
Result: Reduced bacterial load in mouse blood.
Demonstrated greater activity than Linezolid (HY-10394) at equivalent 5 mg/kg and 25 mg/kg doses.
Molecular Weight

587.58

Formula

C34H38IN
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C[N+]1=CC(C2=CC=CC=C2)=C(/C=C/C3=CC=C(C(C)(C)C)C=C3)C=C1C4=CC=C(C(C)(C)C)C=C4.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (198.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7019 mL 8.5095 mL 17.0190 mL
5 mM 0.3404 mL 1.7019 mL 3.4038 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.11%

SDS (252 KB)

COA (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7019 mL 8.5095 mL 17.0190 mL 42.5474 mL
5 mM 0.3404 mL 1.7019 mL 3.4038 mL 8.5095 mL
10 mM 0.1702 mL 0.8509 mL 1.7019 mL 4.2547 mL
15 mM 0.1135 mL 0.5673 mL 1.1346 mL 2.8365 mL
20 mM 0.0851 mL 0.4255 mL 0.8509 mL 2.1274 mL
25 mM 0.0681 mL 0.3404 mL 0.6808 mL 1.7019 mL
30 mM 0.0567 mL 0.2836 mL 0.5673 mL 1.4182 mL
40 mM 0.0425 mL 0.2127 mL 0.4255 mL 1.0637 mL
50 mM 0.0340 mL 0.1702 mL 0.3404 mL 0.8509 mL
60 mM 0.0284 mL 0.1418 mL 0.2836 mL 0.7091 mL
80 mM 0.0213 mL 0.1064 mL 0.2127 mL 0.5318 mL
100 mM 0.0170 mL 0.0851 mL 0.1702 mL 0.4255 mL
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MA220607 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MA2206072922826-56-8MA 220607MA-220607BacterialAcinetobacter baumannii ATCC19606FtsZ proteinbacteremiaStaphylococcus aureus ATCC25923Gram-negative bacteriaEscherichia coli ATCC25922Bacillus subtilis ATCC9372bacterial biofilmGram-positive bacteriamethicillin-resistant Staphylococcus aureus ATCC43300Inhibitorinhibitorinhibit

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