country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-158076

Copy Link Print Information

S2/IAPinh

S2/IAPinh is a conjugate, which consist of an inhibitor for the apoptosis protein inhibitor (IAPinh) and a ligand for sigma 2 SW43. S2/IAPinh exhibits an anti-proliferative and apoptotic-inducing effect through degradation of the cellular inhibitor for apoptosis protein (clAP-1).

For research use only. We do not sell to patients.

Formula: C₅₂H₇₅Cl₂FN₆O₆S
Molecular Weight:1002.16

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

S2/IAPinh Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All IAP Isoforms :

In Vitro

S2/IAPinh (0-100 μM) exhibits cytotoxicity in cancer cells Human pancreatic cancer cell lines AsPC-1, HPAC and MiaPaCa-2, mouse pancreatic cancer cell lines KP2 and human ovarian cancer cell lines OVCAR3/8 with IC₅₀s from 4.6 to 12.8 μM, and induces apoptosis in HPAC and OVCAR8 through activation of caspase 3 and caspase 8^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

AsPC-1, HPAC, MiaPaCa-2, KP2, OVCAR3, OVCAR8
Concentration:

0-100 μM
Incubation Time:

24 h
Result:

Inhibits cell proliferations.

Apoptosis Analysis^[1]

Cell Line:

HPAC and OVCAR8
Concentration:

6 μM
Incubation Time:

6 h
Result:

Induced DNA break.

In Vivo

S2/IAPinh (25 μmol/kg/day, i.p. for 21 days) inhibits tumor growth and improves the survival rate in KP-2 xenograft C57BL/6 mice and OVCAR8 xenograft athymic nude mice without signicifiant toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

KP-2 xenograft C57BL/6 mice and OVCAR8 xenograft athymic nude mice^[1]
Dosage:

25 µmol/ kg
Administration:

i.p., daily for 21 days
Result:

Inhibited tumor growth and improved the mice survival rate without body weight loss.

Chemical Information

Molecular Weight 1002.16
Formula C₅₂H₇₅Cl₂FN₆O₆S
SMILES

O=C(OC1CC(N2CCCCCCCCCCNC(C)C(N[C@H](C(N3CCC[C@@]3([H])C4=NC(C(C5=CC=C(F)C=C5)=O)=CS4)=O)C6CCCCC6)=O)CCCC2C1)NC7=C(OC)C=CC(C)=C7.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hagi T, et al., The novel drug candidate S2/IAPinh improves survival in models of pancreatic and ovarian cancer. Sci Rep. 2024 Mar 16;14(1):6373. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

S2/IAPinh

All IAP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

S2/IAPinh Related Classifications

HY-158076 Related Classifications