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Spastazoline 

Cat. No.: HY-111548 Purity: 98.20%
Handling Instructions

Spastazoline is a potent and selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC50 of 99 nM for Human spastin. Spastazoline shows no effect on ATPase activity of a recombinant human VPS4.

For research use only. We do not sell to patients.

Spastazoline Chemical Structure

Spastazoline Chemical Structure

CAS No. : 2351882-11-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 176 In-stock
Estimated Time of Arrival: December 31
5 mg USD 160 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Spastazoline is a potent and selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC50 of 99 nM for Human spastin. Spastazoline shows no effect on ATPase activity of a recombinant human VPS4[1].

IC50 & Target

IC50: 99 nM (spastin)[1]

Molecular Weight

382.51

Formula

C₂₀H₃₀N₈

CAS No.

2351882-11-4

SMILES

CC(C)(C)C1=CC(NC2=NC(N3CCN[[email protected]](C(C)C)C3)=NC4=C2C=CN4)=NN1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (261.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6143 mL 13.0716 mL 26.1431 mL
5 mM 0.5229 mL 2.6143 mL 5.2286 mL
10 mM 0.2614 mL 1.3072 mL 2.6143 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5.25 mg/mL (13.73 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5.25 mg/mL (13.73 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5.25 mg/mL (13.73 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Product Name:
Spastazoline
Cat. No.:
HY-111548
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