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Cat. No.: HY-17662

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Mol4

(Synonyms: AK-918/41759663)

Mol4 (AK-918/41759663) is a highly selective BCL-2 protein inhibitor (IC₅₀=153.3 μM). Mol4 induces mitochondrial outer membrane permeabilization (MOMP) and cytochrome c release, showing significant antiproliferative activity against glioblastoma (U87-MG) cell lines. Mol4 is promising for research of BCL-2-dependent tumors (e.g., chronic lymphocytic leukemia).

For research use only. We do not sell to patients.

CAS No.: 512800-53-2
Formula: C₃₀H₂₀ClNO₅S
Molecular Weight:542.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Mol4 Chemical Structure

CAS No.: 512800-53-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Bcl-2 Family Isoforms :

Chemical Information

CAS No. 512800-53-2
Molecular Weight 542.00
Formula C₃₀H₂₀ClNO₅S
SMILES

O=C(C1=CC2=C(C(N(C3=CC=C(SC4=CC=C(C)C=C4)C=C3)C2=O)=O)C=C1)OCC(C5=CC=C(Cl)C=C5)=O
Synonyms

AK-918/41759663
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sahin K, et al. Hybrid In Silico and TR-FRET-Guided Discovery of Novel BCL-2 Inhibitors. ACS Pharmacol Transl Sci. 2021 Apr 15;4(3):1111-1123. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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Mol4

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Mol4 Related Classifications

HY-17662 Related Classifications