512800-53-2
512800-53-2
Chemical Structure
Mol4
Synonym(s): AK-918/41759663
- CAS No.: 512800-53-2
- Formula:C30H20ClNO5S
- Molecular Weight:542.00
InChIKey: IHYZTZNGTISQFS-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(C(N(C3=CC=C(SC4=CC=C(C)C=C4)C=C3)C2=O)=O)C=C1)OCC(C5=CC=C(Cl)C=C5)=O
Biological Activity: Mol4 (AK-918/41759663) is a highly selective BCL-2 protein inhibitor (IC50=153.3 μM). Mol4 induces mitochondrial outer membrane permeabilization (MOMP) and cytochrome c release, showing significant antiproliferative activity against glioblastoma (U87-MG) cell lines. Mol4 is promising for research of BCL-2-dependent tumors (e.g., chronic lymphocytic leukemia)[1].
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Mol4 | Mol4 (AK-918/41759663) is a highly selective BCL-2 protein inhibitor (IC50=153.3 μM). Mol4 induces mitochondrial outer membrane permeabilization (MOMP) and cytochrome c release, showing significant antiproliferative activity against glioblastoma (U87-MG) cell lines. Mol4 is promising for research of BCL-2-dependent tumors (e.g., chronic lymphocytic leukemia). | |||||||||||||||||||||
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