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Results for "

epi-

" in MedChemExpress (MCE) Product Catalog:

200

Inhibitors & Agonists

5

Biochemical Assay Reagents

2

Peptides

1

Inhibitory Antibodies

92

Natural
Products

73

Recombinant Proteins

18

Isotope-Labeled Compounds

2

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0001
    (-)-Epicatechin
    Maximum Cited Publications
    12 Publications Verification

    (-)-epicatechol; epicatechin; epi-Catechin

    COX Ferroptosis Endogenous Metabolite Inflammation/Immunology Cancer
    (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.
    (-)-Epicatechin
  • HY-N0227
    7-epi-Taxol
    4 Publications Verification

    7-epi-Paclitaxel

    Microtubule/Tubulin Cancer
    7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.
    7-epi-Taxol
  • HY-100348

    Androgen Receptor PPAR Apoptosis Cancer
    EPI-001, a selective inhibitor of Androgen Receptor (AR), targets transactivation unit 5 (Tau-5) of the AR. EPI-001 can inhibit transactivation of the AR amino-terminal domain (NTD), with an IC50 of ~6 μM. EPI-001 is also a selective modulator of PPARγ. EPI-001 is active against castration-resistant prostate cancer .
    EPI-001
  • HY-16772

    α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075

    Mitochondrial Metabolism Ferroptosis Neurological Disease
    EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione .
    EPI-743
  • HY-P99049

    APX005M; APX005M; epi-0050

    TNF Receptor Inflammation/Immunology
    Sotigalimab, a CD40 agonistic monoclonal antibody. Sotigalimab binds CD40 with high affinity and activates antigen-presenting cells, thereby stimulating cancer-specific T cell responses. Sotigalimab is mainly used in the study of metastatic pancreatic cancer and metastatic melanoma .
    Sotigalimab
  • HY-109070

    epi-002

    Androgen Receptor Cancer
    Ralaniten (EPI-002) is a potent and orally active antagonist of the androgen receptor-N-terminal domain (AR-NTD). Ralaniten inhibits AR transcriptional activity, with IC50 of 7.4 μM. Ralaniten can be used for the research of castration-resistant prostate cancer (CRPC) .
    Ralaniten
  • HY-123875A

    epi-506

    Androgen Receptor Cancer
    Ralaniten triacetate (EPI-506), the pro-agent of Ralaniten, is a first-in-class, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7 .
    Ralaniten triacetate
  • HY-150102
    EPI-7170
    1 Publications Verification

    Androgen Receptor Cancer
    EPI-7170, a ralaniten analogue, is a potent androgen receptor N-terminal structural domain antagonist that blocks the transcriptional activity of full-length AR (FL-AR) and AR splice variants (AR-Vs). EPI-7170 has antitumor effects against enzalutamide resistant castration-resistant prostate cancer (CRPC) .
    EPI-7170
  • HY-N0001R
    (-)-Epicatechin (Standard)
    Maximum Cited Publications
    12 Publications Verification

    (-)-epicatechol(Standard); epicatechin(Standard); epi-Catechin (Standard)

    Reference Standards COX Ferroptosis Endogenous Metabolite Inflammation/Immunology Cancer
    (-)-Epicatechin (Standard) is the analytical standard of (-)-Epicatechin. This product is intended for research and analytical applications. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.
    (-)-Epicatechin (Standard)
  • HY-125999

    Reactive Oxygen Species (ROS) Neurological Disease
    EPI-589, a quinone derivative, is a safe and well tolerated oxidoreductase enzyme inhibitor and a free radical scavenger, with blood-brain barrier permeable and orally available. EPI-589 is a redox-active neuroprotectant that effectively delays the symptoms of motor neuron disease in wobbler mice. EPI-589 can be used in amyotrophic lateral sclerosis (ALS) research .
    EPI-589
  • HY-77572

    7-epi-10-deacetyltaxol; 10-Deacetyl-7-epipaclitaxel

    ADC Payload Cancer
    7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM .
    7-Epi 10-desacetyl paclitaxel
  • HY-N10379

    Akt mTOR Apoptosis Reactive Oxygen Species (ROS) CDK Ras HSP VEGFR TNF Receptor Interleukin Related Inflammation/Immunology
    19-epi-Scholaricine is an orally active indole alkaloid. 19-epi-Scholaricine downregulates the expression of profibrotic/apoptotic proteins (HRAS, HSP90AA1, KDR) and upregulates the expression of cell cycle-related protein (CDK2). 19-epi-Scholaricine suppresses ROS production and reduces the release of inflammatory mediators, thereby attenuating podocyte apoptosis, renal inflammation and oxidative stress by inhibiting AKT/mTOR. 19-epi-Scholaricine can be used in the research of chronic glomerulonephritis and membranous nephropathy .
    19-epi-Scholaricine
  • HY-139058

    27-Deoxyactein

    PPAR Metabolic Disease Cancer
    23-epi-26-Deoxyactein is a natural and orally active anti-obesity and anti-cancer compound .
    23-epi-26-Deoxyactein
  • HY-P10415
    EPI-X4
    1 Publications Verification

    hSA(408–423) peptide

    CXCR Infection Inflammation/Immunology Cancer
    EPI-X4 (hSA408–423 peptide) is an antagonist for C-X-C motif chemokine receptor 4 (CXCR4) with IC50 of 8.6 μM. EPI-X4 blocks the CXCL12-mediated signaling, inhibits chemokine-mediated migration and invasion of leukemia cell. EPI-X4 exhibits anti-inflammatory activity in mouse model. EPI-X4 exhibits antiviral activity against CXCR4-tropic HIV with IC50 of 8.6 μM .
    EPI-X4
  • HY-15398C

    epicholecalciferol

    Hedgehog Cancer
    3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC50 of 39.2 μM measured in U87MG cells .
    3-epi-Vitamin D3
  • HY-N10343

    Others Others
    epi-Progoitrin is the major thioglucoside of Crambe abyssinica seed .
    epi-Progoitrin
  • HY-W765152

    22,23-Dihydro avermectin B1a; epi-Dihydro avermectin B1a

    Parasite Infection
    epi-Ivermectin B1a is a key related substance of Ivermectin (HY-15310), primarily existing as a process-related impurity or potential degradation product in ivermectin-based antiparasitic formulations. epi-Ivermectin B1a can be used for the study of internal/external parasites in cattle .
    epi-Ivermectin B1a
  • HY-138149

    epi-Avermectin B1a

    Drug Metabolite Infection
    2-epi-Abamectin is a degradation product of Abamectin. It is toxic to the two-spotted spider mite in a contact assay with an LC50 value of 4 ppm, which is approximately 100-fold less potent than abamectin.
    2-epi-Abamectin
  • HY-141933S

    3-epi-25-Hydroxy cholecalciferol-d3

    Isotope-Labeled Compounds Others
    3-Epi-25-Hydroxyvitamin D3-d3 is the deuterium labeled 3-Epi-25-Hydroxyvitamin D3 .
    3-epi-Calcifediol-d3
  • HY-W062274A

    4-epi-DU-176b

    Drug Derivative Others
    4-epi-Edoxaban tosylate (4-epi-DU-176b) is a stereoisomer impurity of Edoxaban (HY-10264).
    4-epi-Edoxaban tosylate
  • HY-16676

    4-epi-Docetaxel; 7-epidocetaxel; 7-epitaxotere

    Microtubule/Tubulin Cancer
    7-Epi-10-oxo-docetaxel (Docetaxel Impurity C; 7-Epitaxotere) is a impurity of docetaxel.
    7-Epi-docetaxel
  • HY-N11070

    Others Others
    23-Epi-26-deoxycimicifugoside ia a triterpene xyloside that can be isolated from Cimicifuga racemosa .
    23-Epi-26-deoxycimicifugoside
  • HY-N16573

    Others Cancer
    19-epi-Voacristine is an indole alkaloid. 19-epi-Voacristine exhibits cytotoxic activity against the A2780 ovarian cancer cell line .
    19-epi-Voacristine
  • HY-N7605

    Others Metabolic Disease
    11-epi-mogroside V is a mogroside in the fruit of Siraitia grosvenori. 11-epi-mogroside V exhibits considerable bioactivity in promoting glucose uptake in human HepG2 cells in vitro .
    11-epi-mogroside V
  • HY-N9895

    Others Infection Inflammation/Immunology
    3,5-Dicaffeoyl-epi-quinic acid can be extracted from Chrysanthemum morifolium. 3,5-Dicaffeoyl-epi-quinic acid has antioxidant activities. 3,5-Dicaffeoyl-epi-quinic acid can scavenge DPPH radical and superoxide anion radical, with IC50s of 5.6 and 2.9 μg/mL respectively .
    3,5-Dicaffeoyl-epi-quinic acid
  • HY-N12167

    Others Others
    3-epi-Bufalin (compound 2a) is the microbial transformation product of bufadienolide .
    3-epi-Bufalin
  • HY-N16392

    Endogenous Metabolite Infection
    14-epi-Berkeleylactone F (Compound 8) is a C-14 epimer of Berkeleylactone F (HY-N8386). 14-epi-Berkeleylactone F can be isolated from Penicillium turbatum NRRL 5630. 14-epi-Berkeleylactone F has no significant biological activity against bacterium (Staphylococcus aureus, Bacillus subtilis and E. coli), fungi Candida albicans, the parasite Giardia duodenalis and NS-1 murine myeloma cells .
    14-epi-Berkeleylactone F
  • HY-N3829

    Others Others
    epi-Eudesmol is a Sesquiterpenoids product that can be isolated from the leaves of Laggera alata var. montana C. D. Adams. .
    epi-Eudesmol
  • HY-N7265

    Cholinesterase (ChE) Neurological Disease
    Epi-galantamine is a diastereomer of Galantamine. Epi-galantamine is an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii). Epi-galantamine inhibits AChE with an EC50 of 45.7 μM .
    Epi-galantamine
  • HY-77572R

    7-epi-10-deacetyltaxol (Standard); 10-Deacetyl-7-epipaclitaxel (Standard)

    ADC Payload Reference Standards Cancer
    7-Epi 10-desacetyl paclitaxel (Standard) is the analytical standard of 7-Epi 10-desacetyl paclitaxel. This product is intended for research and analytical applications. 7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM .
    7-Epi 10-desacetyl paclitaxel (Standard)
  • HY-32351B

    3-epi-25-Hydroxy cholecalciferol

    PTHR Endocrinology
    3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats.
    3-epi-Calcifediol
  • HY-90009B

    12-epi-IC-351

    Phosphodiesterase (PDE) Cardiovascular Disease
    12-epi-Tadalafil is a PDE5 inhibitor (IC50: 0.09 μM). 12-epi-Tadalafil can be used for research of cardiovascular diseases .
    12-epi-Tadalafil
  • HY-N11269

    Drug Derivative Others
    Epi-β-amyrin is a chemical component that can be extracted from Euphorbia pulcherrima. Epi-β-amyrin is a steroid compound .
    Epi-β-amyrin
  • HY-150661S

    3-epi-25-Hydroxy Vitamin D3-13C5

    Isotope-Labeled Compounds Others
    3-Epi-25-hydroxyvitamin D3- 13C5 is the 13C labeled 3-Epi-25-hydroxyvitamin D3 .
    3-epi-Calcifediol-13C5
  • HY-B0003A

    1'-epi LY 188011 hydrochloride

    Nucleoside Antimetabolite/Analog Apoptosis DNA/RNA Synthesis Cancer
    1'-epi Gemcitabine hydrochloride is the isomer of Gemcitabine hydrochloride (HY-B0003), and can be used as an experimental control. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .
    1'-epi Gemcitabine hydrochloride
  • HY-N3828

    Apoptosis ERK JNK Cancer
    epi-Eriocalyxin A (Epieriocalyxin A), a diterpenoid isolated from Isodon eriocalyx, induces colon cancer apoptosis. epi-Eriocalyxin A also inhibits ERK1/2 and JNK activation, which suppresses Bcl-2 expression .
    epi-Eriocalyxin A
  • HY-N10623

    Tyrosinase Cancer
    5-epi-Arvestonate A is a sesquiterpenoid isolated from the whole plants of Seriphidium transiliense. 5-epi-Arvestonate A promotes melanogenic production by activating the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes. 5-epi-Arvestonate A inhibits the expression of IFN-γ-chemokine through the JAK/STAT signaling pathway in immortalized human keratinocyte (HaCaT) cells .
    5-epi-Arvestonate A
  • HY-N1690

    Others Others
    21-epi-Serratenediol is a neutral triterpene isolated from Sitka spruce bark .
    21-epi-Serratenediol
  • HY-N12868

    Others Endocrinology
    25-Epi-28-epi-cyasterone (3) is a stereoisomer of cyasterone that can be isolated from Cyathula officinalis .
    25-Epi-28-epi-cyasterone
  • HY-100348R

    Reference Standards Androgen Receptor PPAR Apoptosis Cancer
    EPI-001 (Standard) is the analytical standard of EPI-001. This product is intended for research and analytical applications. EPI-001, a selective inhibitor of Androgen Receptor (AR), targets transactivation unit 5 (Tau-5) of the AR. EPI-001 can inhibit transactivation of the AR amino-terminal domain (NTD), with an IC50 of ~6 μM. EPI-001 is also a selective modulator of PPARγ. EPI-001 is active against castration-resistant prostate cancer .
    EPI-001 (Standard)
  • HY-114961

    15-epi PGA1

    Prostaglandin Receptor Cardiovascular Disease
    15-epi Prostaglandin A1 (15-epi PGA1) is the 15(R) stereoisomer of PGA1. PGA1 causes renal vasodilation, increased urine sodium excretion, and decreased arterial pressure in hypertensive models .
    15-epi Prostaglandin A1
  • HY-W703019

    Biochemical Assay Reagents
    7-Epi lincomycin (hydrochloride) is a kind of biochemical reagent.
    7-Epi lincomycin hydrochloride
  • HY-W016509R

    Endogenous Metabolite Drug Derivative Neurological Disease
    epi-Inositol (Standard) is the analytical standard of epi-Inositol (HY-W016509). This product is intended for research and analytical applications. epi-Inositol, a inositol analog, is an antidepressant agent. epi-Inositol shows regulatory effects on expression of the most highly regulated gene in the inositol biosynthetic pathway. epi-Inositol shows antiepileptic effect .
    epi-Inositol (Standard)
  • HY-B0368C

    epi-D-SQ 14225

    Beta-lactamase Infection
    epi-D-Captopril (epi-D-SQ 14225) is a stereoisomer of Captopril (HY-B0368) and an inhibitor of metallo-β-lactamases (MBLs). The IC50 values of epi-D-Captopril against NDM-1, IMP-1, and VIM-2 are 64 μM, 173 μM, and 5.5 μM, respectively. epi-D-Captopril is expected to be used in the research of diseases caused by MBLs-related drug-resistant bacterial infections .
    epi-D-Captopril
  • HY-W016509

    Drug Derivative Neurological Disease
    epi-Inositol, a inositol analog, is an antidepressant agent. epi-Inositol shows regulatory effects on expression of the most highly regulated gene in the inositol biosynthetic pathway. epi-Inositol shows antiepileptic effect .
    epi-Inositol
  • HY-32351BR

    3-epi-25-hydroxy Cholecalciferol (Standard)

    PTHR Reference Standards Endocrinology
    3-epi-Calcifediol (Standard) is the analytical standard of 3-epi-Calcifediol. This product is intended for research and analytical applications. 3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats.
    3-epi-Calcifediol (Standard)
  • HY-N0227R

    7-epi-Paclitaxel (Standard)

    Reference Standards Microtubule/Tubulin Cancer
    7-epi-Taxol (Standard) is the analytical standard of 7-epi-Taxol. This product is intended for research and analytical applications. 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.
    7-epi-Taxol (Standard)
  • HY-N7748A

    Estrogen Receptor/ERR Prostaglandin Receptor Inflammation/Immunology Endocrinology
    Epi-cryptoacetalide is a natural diterpenoid. Epi-cryptoacetalide reveals high affinity to ER-α and PGE2 receptor (EP2 subtype) with Ki values of 0.3 μM and 1.92 μM, respectively. Epi-cryptoacetalide has anti-endometriosis activities .
    Epi-cryptoacetalide
  • HY-135154

    GABA Receptor Neurological Disease
    epi-Aszonalenin A is a benzodiazepine fungal metabolite originally isolated from Aspergillus novofumigatus. epi-Aszonalenin A can be used as a psychoactive agent .
    epi-Aszonalenin A
  • HY-139058R

    27-Deoxyactein (Standard)

    Reference Standards PPAR Metabolic Disease Cancer
    23-epi-26-Deoxyactein (Standard) is the analytical standard of 23-epi-26-Deoxyactein. This product is intended for research and analytical applications. 23-epi-26-Deoxyactein is a natural and orally active anti-obesity and anti-cancer compound .
    23-epi-26-Deoxyactein (Standard)

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