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Cat. No.: HY-N10623

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5-epi-Arvestonate A

5-epi-Arvestonate A is a sesquiterpenoid isolated from the whole plants of Seriphidium transiliense. 5-epi-Arvestonate A promotes melanogenic production by activating the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes. 5-epi-Arvestonate A inhibits the expression of IFN-γ-chemokine through the JAK/STAT signaling pathway in immortalized human keratinocyte (HaCaT) cells.

For research use only. We do not sell to patients.

CAS No.: 2767066-84-0
Formula: C₁₆H₂₆O₅
Molecular Weight:298.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

5-epi-Arvestonate A Chemical Structure

CAS No.: 2767066-84-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

5-epi-Arvestonate A (50 μM; 48 h) activates the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes in murine melanoma (B16) cells^[1].
5-epi-Arvestonate A (50 μM; 48 h) increases both the mRNA and protein level of TRP-1, TRP-2, TYR, and MITF in murine melanoma (B16) cells^[1].
5-epi-Arvestonate A (10 μM, 50 μM; 24 h) disrupts the IFN-γ-chemokine and CXCL10/9 production through the JAK/STAT signal pathway in IFN-γ-activated HaCaT cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Murine melanoma (B16) cells; IFN-γ-activated HaCaT cells
Concentration:

1, 10, 50 μM
Incubation Time:

24 hours and 48 hours
Result:

Increased the protein level of TRP-1, TRP-2, TYR, and MITF at 50 μM concentration in murine melanoma (B16) cells.
Decreased the protein level of IFN-γ, CXCL9/10 in IFN-γ-activated HaCaT cells for 24 hr.

Cell Viability Assay^[1]

Cell Line:

Murine melanoma (B16) cells
Concentration:

1, 10, 50 μM
Incubation Time:

48 hours
Result:

Increased the viability of B16, increased the levels of both relative melanin content and relative tyrosinase activity.

Chemical Information

CAS No. 2767066-84-0
Molecular Weight 298.37
Formula C₁₆H₂₆O₅
SMILES

C[C@@]1([C@@H](CCC([C@]1([C@H]2O)O)=C)O)CC[C@@]2([H])[C@@H](C)C(OC)=O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Seriphidium transiliense
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu JF, et al. Sesquiterpenoids from Seriphidium transiliense and Their Melanogenic Activity. J Nat Prod. 2022 Nov 3. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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