2. CB1151

CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC50 value of 0.82 nM.

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CB1151 Chemical Structure

CB1151 Chemical Structure

CAS No. : 182369-28-4

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CB1151 Related Antibodies

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Description

CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC50 value of 0.82 nM[1].

IC50 & Target

IC50: 0.82 nM[1]
In Vitro

CB1151 (0-100 nM; 5 days) inhibits MCF-7 cells growth, this cell proliferation is accessed by [3H]-thymidine incorporation, exhibits an IC50 value of 0.82 nM[1].
CB1151 (0-100 nM; 40 hours) exhibits activation of the IP9-type VD response element with a EC50 of 1.2 nM, the activation of IP9-type VD response elements shows a good correlation with inhibition of proliferation than the activation of DR3-type elements (EC50=3.2nM) in MCF-7 cells transfected with the CAT reporter[1].
CB1151 shows a functional dissociation constant (Kdf) value of 3.6 nM. The ligand concentration that provides 50% of protease-resistant VDR fragment is defined by Kdf, this is different from that of the traditional dissociation constant (Kd)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CB1151 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF-7 cell
Concentration: 0 nM; 0.1nM; 0.5nM; 0.8nM; 1nM; 5nM; 10 nM
Incubation Time: 5 days
Result: Inhibits MCF-7 cells growth.
Molecular Weight

446.66

Formula

C28H46O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]1(CCC/2)[C@](CC[C@@H]1[C@@H](C)OCCC(CC)(CC)O)([H])C2=C\C=C(C[C@@H](O)C[C@@H]3O)/C3=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (223.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2388 mL 11.1942 mL 22.3884 mL
5 mM 0.4478 mL 2.2388 mL 4.4777 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2388 mL 11.1942 mL 22.3884 mL 55.9710 mL
5 mM 0.4478 mL 2.2388 mL 4.4777 mL 11.1942 mL
10 mM 0.2239 mL 1.1194 mL 2.2388 mL 5.5971 mL
15 mM 0.1493 mL 0.7463 mL 1.4926 mL 3.7314 mL
20 mM 0.1119 mL 0.5597 mL 1.1194 mL 2.7985 mL
25 mM 0.0896 mL 0.4478 mL 0.8955 mL 2.2388 mL
30 mM 0.0746 mL 0.3731 mL 0.7463 mL 1.8657 mL
40 mM 0.0560 mL 0.2799 mL 0.5597 mL 1.3993 mL
50 mM 0.0448 mL 0.2239 mL 0.4478 mL 1.1194 mL
60 mM 0.0373 mL 0.1866 mL 0.3731 mL 0.9328 mL
80 mM 0.0280 mL 0.1399 mL 0.2799 mL 0.6996 mL
100 mM 0.0224 mL 0.1119 mL 0.2239 mL 0.5597 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB1151182369-28-4CB 1151CB-1151Inhibitorinhibitorinhibit

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