1. Vitamin D Related
  2. VD/VDR
  3. CB1151

CB1151 

Cat. No.: HY-100219
Handling Instructions

CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC50 value of 0.82 nM.

For research use only. We do not sell to patients.

CB1151 Chemical Structure

CB1151 Chemical Structure

CAS No. : 182369-28-4

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC50 value of 0.82 nM[1].

IC50 & Target

IC50: 0.82 nM[1]

In Vitro

CB1151 (0-100 nM; 5 days) inhibits MCF-7 cells growth, this cell proliferation is accessed by [3H]-thymidine incorporation, exhibits an IC50 value of 0.82 nM[1].
CB1151 (0-100 nM; 40 hours) exhibits activation of the IP9-type VD response element with a EC50 of 1.2 nM, the activation of IP9-type VD response elements shows a good correlation with inhibition of proliferation than the activation of DR3-type elements (EC50=3.2nM) in MCF-7 cells transfected with the CAT reporter[1].
CB1151 shows a functional dissociation constant (Kdf) value of 3.6 nM. The ligand concentration that provides 50% of protease-resistant VDR fragment is defined by Kdf, this is different from that of the traditional dissociation constant (Kd)[2].

Cell Proliferation Assay[1]

Cell Line: MCF-7 cell
Concentration: 0 nM; 0.1nM; 0.5nM; 0.8nM; 1nM; 5nM; 10 nM
Incubation Time: 5 days
Result: Inhibits MCF-7 cells growth.
Molecular Weight

446.66

Formula

C₂₈H₄₆O₄

CAS No.

182369-28-4

SMILES

C[[email protected]]1(CCC/2)[[email protected]](CC[[email protected]@H]1[[email protected]@H](C)OCCC(CC)(CC)O)([H])C2=C\C=C(C[[email protected]@H](O)C[[email protected]@H]3O)/C3=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CB1151CB 1151CB-1151VD/VDRVitamin DVitamin D receptorVDVitmanMCF-7Celltumor20-epiisomerInhibitorinhibitorinhibit

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CB1151
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