7-Epi 10-desacetyl paclitaxel (Standard)
7-Epi 10-desacetyl paclitaxel (Standard) (7-epi-10-deacetyltaxol (Standard); 10-Deacetyl-7-epipaclitaxel (Standard)) is the analytical standard of 7-Epi 10-desacetyl paclitaxel (HY-77572). This product is intended for research and analytical applications. 7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol; 10-Deacetyl-7-epipaclitaxel) is a taxane diterpenoid that can be found in Taxus species and is also produced by the endophytic fungus Pestalotiopsis microspora. 7-Epi 10-desacetyl paclitaxel inhibits cancer cell proliferation and induces apoptosis and cell cycle arrest. 7-Epi 10-desacetyl paclitaxel induces apoptosis through the intrinsic mitochondrial pathway, a process associated with ROS generation, an increased Bax/Bcl-2 ratio, and PARP cleavage. 7-Epi 10-desacetyl paclitaxel can be used in research on hepatocellular carcinoma.
For research use only. We do not sell to patients.
- CAS No.: 78454-17-8
- Formula: C₄₅H₄₉NO₁₃
- Molecular Weight:811.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 78454-17-8
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Molecular Weight 811.87
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Formula C₄₅H₄₉NO₁₃
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SMILES
O=C(N[C@@H](C1=CC=CC=C1)[C@@H](O)C(O[C@H]2C[C@@](O)([C@@H](OC(C3=CC=CC=C3)=O)[C@@]4([H])[C@@]5(C)[C@H](O)C[C@]6([H])[C@@]4(OC(C)=O)CO6)C(C)(C)C([C@@H](O)C5=O)=C2C)=O)C7=CC=CC=C7
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Synonyms
7-epi-10-deacetyltaxol (Standard); 10-Deacetyl-7-epipaclitaxel (Standard)
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- 7-Epi 10-desacetyl paclitaxel (Standard)
- 78454-17-8
- 7-epi-10-deacetyltaxol (Standard)
- 10-Deacetyl-7-epipaclitaxel (Standard)
- Reference Standards
- Endogenous Metabolite
- Apoptosis
- Reactive Oxygen Species (ROS)
- Bcl-2 Family
- PARP
- G2/M phase cell cycle arrest
- Pestalotiopsis microspora
- PARP cleavage
- p38 MAPK
- Bax/Bcl-2 ratio
- Taxus species
- taxane diterpenoid
- intrinsic mitochondrial pathway
- HepG2 cells
- reactive oxygen species
- Inhibitor
- inhibitor
- inhibit