Cat. No.: HY-N1725

2-Desoxy-4-epi-pulchellin

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2-Desoxy-4-epi-pulchellin (compound 13) is a compound isolated from dichloromethane-soluble portion of Polygonum hydropiper.

For research use only. We do not sell to patients.

Purity: 99.97%
CAS No.: 122872-03-1
Formula: C₁₅H₂₂O₃
Molecular Weight:250.33

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

2-Desoxy-4-epi-pulchellin Chemical Structure

CAS No.: 122872-03-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

2-Desoxy-4-epi-pulchellin (compound 13) is a compound isolated from dichloromethane-soluble portion of Polygonum hydropiper^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	6.2 μM Compound: 4	Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
DU-145	IC₅₀	3.1 μM Compound: 4	Cytotoxicity against human DU145 cells after 72 hrs by CCK8 assay Cytotoxicity against human DU145 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
HCT-116	IC₅₀	4.43 μM Compound: 1; PCL	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30711391]
HeLa	IC₅₀	6 μM Compound: 4	Cytotoxicity against human HeLa cells after 72 hrs by CCK8 assay Cytotoxicity against human HeLa cells after 72 hrs by CCK8 assay	[PMID: 26316467]
HL-60	IC₅₀	2.4 μM Compound: 4	Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
HT-29	IC₅₀	3.37 μM Compound: 1; PCL	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30711391]
K562	IC₅₀	17 μM Compound: 4	Cytotoxicity against human K562 cells after 72 hrs by CCK8 assay Cytotoxicity against human K562 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
MCF7	IC₅₀	11 μM Compound: 4	Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
MCF7	IC₅₀	9.8 μg/mL Compound: 9, pseudoguaianolide	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21109433]
MDCK	IC₅₀	29.3 μM Compound: 4	Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining	[PMID: 26316467]
MDCK	IC₅₀	47.3 μM Compound: 4	Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining	[PMID: 26316467]
MOLT-4	IC₅₀	5.5 μM Compound: 4	Cytotoxicity against human MOLT4 cells after 72 hrs by CCK8 assay Cytotoxicity against human MOLT4 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
NCI-H1975	IC₅₀	13 μM Compound: 4	Cytotoxicity against human NCI-H1975 cells after 72 hrs by CCK8 assay Cytotoxicity against human NCI-H1975 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
Neutrophil	IC₅₀	>10 μg/mL Compound: 5	Inhibition of FMLP/CB-induced elastase release in human neutrophils after 5 mins by spectrophotometry Inhibition of FMLP/CB-induced elastase release in human neutrophils after 5 mins by spectrophotometry	[PMID: 24997688]
Neutrophil	IC₅₀	>10 μg/mL Compound: 5	Inhibition of FMLP/CB-induced superoxide anion generation in human neutrophils by ferricytochrome c reduction method Inhibition of FMLP/CB-induced superoxide anion generation in human neutrophils by ferricytochrome c reduction method	[PMID: 24997688]
RAW264.7	IC₅₀	0.1 μM Compound: 14	Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs	[PMID: 20515062]
RAW264.7	IC₅₀	14.9 μM Compound: 5	Inhibition of NO production in LPS/IFN-gamma activated mouse RAW264.7 cells after 24 hrs by Griess assay Inhibition of NO production in LPS/IFN-gamma activated mouse RAW264.7 cells after 24 hrs by Griess assay	[PMID: 24997688]
RAW264.7	IC₅₀	2.5 μM Compound: 15	Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay	[PMID: 27276091]
RAW264.7	IC₅₀	9.89 μM Compound: 19	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method	[PMID: 21924800]
SGC-7901	IC₅₀	22 μM Compound: 4	Cytotoxicity against human SGC7901 cells after 72 hrs by CCK8 assay Cytotoxicity against human SGC7901 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
U-937	IC₅₀	2.2 μM Compound: 4	Cytotoxicity against human U937 cells after 72 hrs by CCK8 assay Cytotoxicity against human U937 cells after 72 hrs by CCK8 assay	[PMID: 26316467]

Chemical Information

CAS No. 122872-03-1
Appearance Solid
Molecular Weight 250.33
Formula C₁₅H₂₂O₃
Color White to off-white
SMILES

O=C(O[C@]1([H])[C@]2([H])C[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@H](C)C1)C2=C
Structure Classification
- Others
Initial Source
- Plants
- Compositae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (99.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.9947 mL

19.9736 mL

39.9473 mL

5 mM

0.7989 mL

3.9947 mL

7.9895 mL

10 mM

0.3995 mL

1.9974 mL

3.9947 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiao H, et al. Biological evaluation of phytoconstituents from Polygonum hydropiper. Nat Prod Res. 2017;31(17):2053-2057. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.9947 mL	19.9736 mL	39.9473 mL	99.8682 mL
	5 mM	0.7989 mL	3.9947 mL	7.9895 mL	19.9736 mL
	10 mM	0.3995 mL	1.9974 mL	3.9947 mL	9.9868 mL
	15 mM	0.2663 mL	1.3316 mL	2.6632 mL	6.6579 mL
	20 mM	0.1997 mL	0.9987 mL	1.9974 mL	4.9934 mL
	25 mM	0.1598 mL	0.7989 mL	1.5979 mL	3.9947 mL
	30 mM	0.1332 mL	0.6658 mL	1.3316 mL	3.3289 mL
	40 mM	0.0999 mL	0.4993 mL	0.9987 mL	2.4967 mL
	50 mM	0.0799 mL	0.3995 mL	0.7989 mL	1.9974 mL
	60 mM	0.0666 mL	0.3329 mL	0.6658 mL	1.6645 mL
	80 mM	0.0499 mL	0.2497 mL	0.4993 mL	1.2484 mL

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2-Desoxy-4-epi-pulchellin

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Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

2-Desoxy-4-epi-pulchellin

Bioactive Compound Library Max

Bioactive Compound Library

Natural Product Library

Plant-Sourced Natural Product Library

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

2-Desoxy-4-epi-pulchellin Related Classifications

HY-N1725 Related Classifications