Biological evaluation of phytoconstituents from Polygonum hydropiper

  • Nat Prod Res. 2017 Sep;31(17):2053-2057. doi: 10.1080/14786419.2016.1269094.
Hong Xiao  1 ,  Ranga Rao Ravu  2 ,  Babu L Tekwani  2  3 ,  Wei Li  1 ,  Wen-Bin Liu  1 ,  Melissa R Jacob  2 ,  Shabana I Khan  2  3 ,  Xiong Cai  4 ,  Cai-Yun Peng  1 ,  Ikhlas A Khan  2  3 ,  Xing-Cong Li  2  3 ,  Wei Wang  1
Affiliations
  • 1. a TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy , Hunan University of Chinese Medicine , Changsha , P.R. China.
  • 2. b National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy , The University of Mississippi , Oxford , MS , USA.
  • 3. c Department of Biomolecular Sciences, School of Pharmacy , The University of Mississippi , MS , USA.
  • 4. d Hunan Provincial Key Laboratory of Diagnostic and Therapeutic Research in Chinese Medicine , Hunan University of Chinese Medicine , Changsha , P.R. China.
PMID: 28000515 DOI: 10.1080/14786419.2016.1269094
Abstract

Fourteen compounds including vanicoside B (1), vanicoside F (2), vanicoside E (3) and 5,6-dehydrokawain (4), aniba-dimer-A (5), 6,6'-((1α,2α,3β,4β)-2,4-diphenylcyclobutane-1,3-diyl)bis(4-methoxy-2H-pyran-2-one) (6), (+)-ketopinoresinol (7), isorhamnetin (8), 3,7-dihydroxy-5,6-dimethoxy-flavone (9), isalpinin (10), cardamomin (11), pinosylvin (12), 2-desoxy-4-epi-pulchellin (13) and β-sitosterol (14) were isolated from dichloromethane-soluble portion of Polygonum hydropiper. By using Alamar blue assay, compounds 2, 7, 8, 11 and 12 were found to be active against Trypanosoma brucei with IC50 values in the range of 0.49-7.77 μg/mL. Cardamomin (11) had most significant activity against T. brucei with IC50/IC90 values of 0.49/0.81 μg/mL compared to the positive control DFMO (IC50/IC90: 3.02/8.05 μg/mL). Furthermore, in antimalarial, antimicrobial, anti-inflammatory, PPAR and cytotoxic assays, some compounds have demonstrated moderate inhibitory potentials.

Keywords
Polygonaceae; Polygonum hydropiper; antitrypanosomal; bioassay.
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