Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells

  • J Nat Prod. 2016 Jun 24;79(6):1548-53. doi: 10.1021/acs.jnatprod.5b01106.
Qinghao Jin  1 ,  Jin Woo Lee  1 ,  Hari Jang  1 ,  Ji Eun Choi  1 ,  Dongho Lee  2 ,  Jin Tae Hong  1 ,  Youngsoo Kim  1 ,  Mi Kyeong Lee  1 ,  Bang Yeon Hwang  1
Affiliations
  • 1. College of Pharmacy, Chungbuk National University , Cheongju 28644, Korea.
  • 2. Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University , Seoul 02841, Korea.
PMID: 27276091 DOI: 10.1021/acs.jnatprod.5b01106
Abstract

Eight new Sesquiterpenes (1-8), along with seven known Sesquiterpenes (9-15), were isolated from a methanol extract of the flowers of Inula japonica. Their structures were elucidated by a combination of 1D and 2D NMR spectroscopic and HRESIMS data. All of isolates were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 cells, with their IC50 values ranging from 1.9 to 15.4 μM.