2. Epigenetics TGF-beta/Smad Stem Cell/Wnt
  3. PKC PKA
  4. UCN-02

UCN-02  (Synonyms: 7-epi-Hydroxystaurosporine)

Cat. No.: HY-108262 Purity: 95%
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UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor with a PKC IC50 value of 62 nM and a PKA IC50 value of 0.25 μM. UCN-02 can be produced by Streptomyces strain N-126. UCN-02 can be used for the research of breast carcinoma.

For research use only. We do not sell to patients.

UCN-02

UCN-02 Chemical Structure

CAS No. : 121569-61-7

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UCN-02 Related Antibodies

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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PKA PKAR PKACα

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Description

UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor with a PKC IC50 value of 62 nM and a PKA IC50 value of 0.25 μM. UCN-02 can be produced by Streptomyces strain N-126. UCN-02 can be used for the research of breast carcinoma[1][2][3][4].

IC50 & Target

IC50: 62 nM (PKC), 250 nM (PKA)[2]
In Vitro

UCN-02 (0.25-0.37 μg/mL; 48-72 h) is produced by Streptomyces strain N-126[1].
UCN-02 inhibits purified protein kinase C (PKC) with an IC50 of 0.062 μM[2].
UCN-02 inhibits purified protein kinase A (PKA) with an IC50 of 0.25 μM[2].
UCN-02 (72 h) inhibits the growth of HeLa S3 cells[2].
UCN-02 (5-6 days) inhibits the growth of human breast carcinoma cell lines MDA-MB468 (IC50 = 100 nM), H85787 (IC50 = 20 nM), SK-BR-3 (IC50 = 200 nM), MDA-MB453 (IC50 = 350 nM), and MCF-7 (IC50 = 150 nM)[3].
UCN-02 (24 h-6 days) causes exposure-dependent growth inhibition in MDA-MB468 and MCF-7 human breast carcinoma cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UCN-02 Related Antibodies
Molecular Weight

482.53

Formula

C28H26N4O4
CAS No.
Appearance

Liquid (Density: 1.63±0.1 g/cm3)

Color

Colorless to light yellow

SMILES

C[C@]12N3C4=C(C5=CC=CC=C53)C([C@@H](NC6=O)O)=C6C7=C4N([C@](C[C@H]([C@H]2OC)NC)([H])O1)C8=CC=CC=C78
Structure Classification
Initial Source

Streptomyces sp. N-126.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (265 KB)

Handling Instructions (2659 KB)
References
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UCN-02 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UCN-02121569-61-77-epi-HydroxystaurosporineUCN02UCN 02PKCPKAProtein kinase CProtein kinase APKC-βPKC-αprotein kinase APKC-δprotein kinase CPKC-εHeLa S3 cellsPKC-ζPKC-γbreast carcinomaInhibitorinhibitorinhibit

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