1. Epigenetics
    TGF-beta/Smad
    Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
  2. PKC
    PKA
  3. UCN-02

UCN-02 (Synonyms: 7-epi-Hydroxystaurosporine)

Cat. No.: HY-108262
Handling Instructions

UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC50s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively. UCN-02 (7-epi-Hydroxystaurosporine) displays cytotoxic effect on the growth of HeLa S3 cells.

For research use only. We do not sell to patients.

UCN-02 Chemical Structure

UCN-02 Chemical Structure

CAS No. : 121569-61-7

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Description

UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC50s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively. UCN-02 (7-epi-Hydroxystaurosporine) displays cytotoxic effect on the growth of HeLa S3 cells[1][2].

IC50 & Target

IC50: 62 nM (PKC), 250 nM (PKA)[2]

Molecular Weight

482.53

Formula

C₂₈H₂₆N₄O₄

CAS No.

121569-61-7

SMILES

O=C1C2=C([[email protected]](O)N1)C3=C(N4C5=C3C=CC=C5)C6=C2C7=CC=CC=C7N6[[email protected]]8([H])O[[email protected]@]4(C)[[email protected]](OC)[[email protected]](NC)C8

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