2. Epigenetics TGF-beta/Smad Stem Cell/Wnt
  3. PKC PKA
  4. UCN-02

UCN-02  (Synonyms: 7-epi-Hydroxystaurosporine)

Cat. No.: HY-108262
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UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC50s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively. UCN-02 (7-epi-Hydroxystaurosporine) displays cytotoxic effect on the growth of HeLa S3 cells.

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UCN-02 Chemical Structure

UCN-02 Chemical Structure

CAS No. : 121569-61-7

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Based on 1 publication(s) in Google Scholar

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Description

UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC50s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively. UCN-02 (7-epi-Hydroxystaurosporine) displays cytotoxic effect on the growth of HeLa S3 cells[1][2].

IC50 & Target

IC50: 62 nM (PKC), 250 nM (PKA)[2]
Molecular Weight

482.53

Formula

C28H26N4O4
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C1C2=C([C@H](O)N1)C3=C(N4C5=C3C=CC=C5)C6=C2C7=CC=CC=C7N6[C@]8([H])O[C@@]4(C)[C@H](OC)[C@H](NC)C8
Structure Classification
Initial Source

Streptomyces sp. N-126.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

COA (261 KB)

Handling Instructions (2659 KB)
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UCN-02 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UCN-02121569-61-77-epi-HydroxystaurosporineUCN02UCN 02PKCPKAProtein kinase CProtein kinase AInhibitorinhibitorinhibit

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