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Results for "

anti-inflammatory+effect

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (2) Akt (3) AMPK (3) Amylases (3) Antibiotic (10) AP-1 (1) Apoptosis (11) Autophagy (5) Bacterial (24) Calcium Channel (1) Cannabinoid Receptor (1) Carbonic Anhydrase (2) Caspase (1) Cathepsin (1) CCR (3) CD44 (1) COX (21) CXCR (1) DAPK (1) Dihydroorotate Dehydrogenase (1) DNA/RNA Synthesis (1) Drug Isomer (1) Drug Metabolite (2) E1/E2/E3 Enzyme (1) Elastase (1) Endogenous Metabolite (5) ERK (2) Estrogen Receptor/ERR (1) Factor Xa (2) Ferroptosis (5) Formyl Peptide Receptor (FPR) (2) Fungal (5) GABA Receptor (1) Glucocorticoid Receptor (2) Glycosidase (3) GSK-3 (1) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (5) Histone Methyltransferase (8) Hydroxycarboxylic Acid Receptor (HCAR) (1) Influenza Virus (1) Integrin (2) Interleukin Related (12) IRAK (1) Isotope-Labeled Compounds (6) JAK (4) JNK (3) Keap1-Nrf2 (6) Leukotriene Receptor (2) Lipoxygenase (3) mAChR (1) Macrophage migration inhibitory factor (MIF) (1) MAP3K (1) MAPKAPK2 (MK2) (2) MEK (1) Mitophagy (2) MMP (2) mTOR (1) MyD88 (1) NF-κB (15) NO Synthase (9) NOD-like Receptor (NLR) (1) Nuclear Hormone Receptor 4A/NR4A (7) Opioid Receptor (1) Organoid (3) P-glycoprotein (1) P-selectin (1) p38 MAPK (10) Parasite (9) PERK (2) PGE synthase (3) PI3K (3) Potassium Channel (1) PPAR (1) Prostaglandin Receptor (2) Proteasome (2) Reactive Oxygen Species (ROS) (3) Reference Standards (26) RIP kinase (1) ROR (1) STAT (7) TGF-β Receptor (3) Thrombin (2) TNF Receptor (5) Transmembrane Glycoprotein (1) VEGFR (1)
By Research Areas:	Cancer (36) Cardiovascular Disease (6) Infection (33) Inflammation/Immunology (133) Metabolic Disease (10) Neurological Disease (23)
Oligonucleotides:	Aptamers (2)

154

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13418A

Dorsomorphin Maximum Cited Publications 754 Publications Verification Compound C; BML-275	Organoid AMPK TGF-β Receptor Autophagy	Cancer
Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor (K_i=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599) .

HY-13418

Dorsomorphin dihydrochloride Maximum Cited Publications 754 Publications Verification Compound C dihydrochloride; BML-275 dihydrochloride	Organoid AMPK TGF-β Receptor Autophagy	Cancer
Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a K_i of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).

HY-112847A

Sulfosuccinimidyl oleate sodium 35+ Cited Publications Sulfo-N-succinimidyl oleate sodium	Mitophagy	Inflammation/Immunology
Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect .

HY-B1322

Amodiaquine dihydrochloride dihydrate 10+ Cited Publications Amodiaquin dihydrochloride dihydrate	Nuclear Hormone Receptor 4A/NR4A Parasite Histone Methyltransferase	Infection Neurological Disease Inflammation/Immunology
Amodiaquine dihydrochloride dihydrate (Amodiaquin dihydrochloride dihydrate), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride dihydrate is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect .

HY-N0516

Casticin 5+ Cited Publications Vitexicarpin	STAT	Inflammation/Immunology
Casticin is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.

HY-B1322A

Amodiaquine 10+ Cited Publications Amodiaquin	Nuclear Hormone Receptor 4A/NR4A Parasite Histone Methyltransferase	Infection Neurological Disease Inflammation/Immunology
Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect .

HY-B1892

Cefazolin 10+ Cited Publications Cephazolin	Antibiotic Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
Cefazolin (Cephazolin) is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research . Cefazolin has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD) .

HY-B0450

Ciclopirox 5+ Cited Publications HOE296b	Fungal Bacterial Ferroptosis Autophagy	Infection Inflammation/Immunology Cancer
Ciclopirox (HOE296b) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox also has anticancer and anti-inflammatory effect .

HY-Z0548

Methyl 3,4-dihydroxybenzoate Protocatechuic acid methyl ester; Methyl protocatechuate	Keap1-Nrf2 Apoptosis	Inflammation/Immunology Cancer
Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect .

HY-B1078

Cefazolin sodium 10+ Cited Publications Cephazolin sodium	Bacterial Antibiotic	Infection Neurological Disease Inflammation/Immunology Cancer
Cefazolin sodium is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research . Cefazolin sodium has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD) .

HY-B0450A

Ciclopirox olamine 5+ Cited Publications Ciclopirox ethanolamine; HOE 296	Fungal Bacterial Ferroptosis	Infection Cancer
Ciclopirox olamine (Ciclopirox ethanolamine) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox olamine also has anticancer and anti-inflammatory effect .

HY-112578

Betanin	Others	Metabolic Disease Inflammation/Immunology
Betanin has potent antioxidant and anti-inflammatory effect, that could inhibit peroxynitrite (ONOO ^-), with an IC₅₀ of 19.2 μM. Betanin is a red glycoside obtained from beets that can be used as colorant.

HY-B1322B

Amodiaquine dihydrochloride 10+ Cited Publications Amodiaquin dihydrochloride	Nuclear Hormone Receptor 4A/NR4A Parasite Histone Methyltransferase	Infection Neurological Disease Inflammation/Immunology
Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor with a K_i of 18.6 nM. Amodiaquine dihydrochloride is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect .

HY-N0802

Tenuigenin 3 Publications Verification Senegenin	NF-κB Bacterial	Infection Inflammation/Immunology
Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect .

HY-114200

Imrecoxib BAP-909	COX	Inflammation/Immunology
Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC₅₀ value of 18 nM, it also inhibits COX1- activity with an IC₅₀ value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect .

HY-121356

Carebastine 1 Publications Verification	Histamine Receptor Macrophage migration inhibitory factor (MIF) VEGFR Akt Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Carebastine is an Ebastine (HY-B0674) metabolite and H1-receptor antagonist. Carebastine inhibits VEGFR-2 and Akt phosphorylation. Carebastine exerts an anti-inflammatory effect by inhibiting MIF as well as TNF-α and IL-6 production. Carebastine shows anti-angiogenic activity

HY-N5015

Rosmanol 1 Publications Verification	COX	Inflammation/Immunology Cancer
Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

HY-B0714

Dexketoprofen (trometamol) 2 Publications Verification Dexketoprofen tromethamine salt	COX	Neurological Disease Inflammation/Immunology Cancer
Dexketoprofen trometamol (Dexketoprofen tromethamine salt) is an orally active non-selective COX inhibitor. Dexketoprofen trometamol has a pain-relieving effect, anti-inflammatory effect and anti-cancer effect .

HY-13236

LUF6000 1 Publications Verification	Adenosine Receptor	Cardiovascular Disease
LUF6000 is an orally active allosteric modulator of the A3 adenosine receptor. LUF6000 has potent anti-inflammatory effect .

HY-B1355A

Oxyphenbutazone	COX Bacterial	Infection Inflammation/Immunology
Oxyphenbutazone is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone is an orally active non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis .

HY-162231

HY-078020	Histamine Receptor mAChR	Inflammation/Immunology
HY-078020 (compound III-4) is a selective, orally active antagonist for histamine H1 receptor with an IC₅₀ of 24.12 nM. HY-078020 exhibits an anti-inflammatory effect in allergic diseases .

HY-118545

Butamirate	STAT	Inflammation/Immunology Cancer
Butamirate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate can be used for the study of glioblastoma .

HY-135658

hDHODH-IN-1	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Inflammation/Immunology
hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory effect .

HY-N7630

Rehmapicrogenin	NO Synthase COX	Inflammation/Immunology
Rehmapicrogenin, isolated from the root of Rehmannia glutinosa, exhibits potent anti-inflammatory effect by inhibiting iNOS, COX-2 and IL-6 .

HY-N0023

Cistanoside A	NO Synthase	Inflammation/Immunology
Cistanoside A is a phenylethanoid isolated from Cistanche deserticola, reduces NO accumulation, but shows no effect on iNOS mRNA, iNOS protein levels or iNOS activity. Anti-inflammatory effect .

HY-N6826

Asatone 3 Publications Verification	NF-κB	Inflammation/Immunology
Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways .

HY-N2556

Tirucallol	Others	Inflammation/Immunology
Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages .

HY-N4134

Ciwujianoside C3	NO Synthase	Inflammation/Immunology
Ciwujianoside C3, an orally active and brain penetrated compound, is isolated the leaves of Acanthopanax henryi Harms. Ciwujianoside C3 has anti-inflammatory effect and can reinforces object recognition memory .

HY-N1388

Tussilagone 3 Publications Verification	Others	Inflammation/Immunology
Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice .

HY-118545A

Butamirate citrate	STAT	Inflammation/Immunology Cancer
Butamirate citrate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate citrate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate citrate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate citrate can be used for the study of glioblastoma .

HY-P1328

TAT-14 1 Publications Verification	Keap1-Nrf2	Others
TAT-14 is a 14-mer peptide that acts as Nrf2 activator with an anti-inflammatory effect. TAT-14 has no effect on Nrf2 mRNA expression, but increases Nrf2 protein level due to targeting the Nrf2 binding site on Keap1 .

HY-N8371

Shizukaol B	NO Synthase COX Interleukin Related TNF Receptor	Inflammation/Immunology
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression .

HY-N7697A

Chitopentaose pentahydrochloride	Others	Inflammation/Immunology
Chitopentaose pentahydrochloride is a chitosan oligosaccharide with anti-inflammatory effect. Chitopentaose pentahydrochloride is a substrate of gene encoding chitinase B (FjchiB) .

HY-156621

Lepzacitinib	JAK	Inflammation/Immunology
Lepzacitinib is a Janus kinase inhibitor targeting to JAK 1/3. Lepzacitinib exhibits anti-inflammatory effect and inhibits atopic dermatitis and other skin diseases .

HY-N2495

Isomucronulatol	Others	Inflammation/Immunology
Isomucronulatol is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol exhibits inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect .

HY-P990057

Picankibart IBI-112	Interleukin Related	Cancer
Picankibart is a human-derived IgG1κ antibody targeting IL23A. Picankibart specifically binds to the IL23 p19 subunit and exerts an anti-inflammatory effect by blocking the IL23-mediated signaling pathway.

HY-139578

Ocarocoxib	COX	Inflammation/Immunology
Ocarocoxib is a potent cyclooxygenase-2 (COX-2) inhibitor (IC₅₀: 1.4 μM). Ocarocoxib inhibits COX to block the production of prostaglandins, thus exerting an anti-inflammatory effect. Ocarocoxib has potential in the study of inflammation and related diseases .

HY-112847

Sulfosuccinimidyl oleate Sulfo-N-succinimidyl oleate	Mitophagy	Inflammation/Immunology
Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect .

HY-101445R

Trolox (Standard)	Reference Standards Reactive Oxygen Species (ROS) Ferroptosis Apoptosis	Cancer
Butamirate (citrate) (Standard) is the analytical standard of Butamirate (citrate). This product is intended for research and analytical applications. Butamirate citrate is an orally active cough suppressant that acts centrally through the receptors in the brainstem. Butamirate citrate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect .

HY-N0406

2"-O-beta-L-galactopyranosylorientin	P-glycoprotein	Inflammation/Immunology
2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2). Anti-inflammatory effect .

HY-B1892S1

Cefazolin-13C2,15N Cephazolin-¹³C₂,¹⁵N	Isotope-Labeled Compounds Antibiotic Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
Cefazolin- ¹³C₂, ¹⁵N (Cephazolin- ¹³C₂, ¹⁵N) is ¹³C and ¹⁵N labeled Cefazolin. Cefazolin (Cephazolin) is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research . Cefazolin has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD) .

HY-N4312

Bryodulcosigenin 1 Publications Verification 11-Oxomogrol	Others	Inflammation/Immunology
Bryodulcosigenin is an extract of the roots of Bryoniadioica with anti-inflammatory effect .

HY-B1046S

Clofazimine-d7	Bacterial Antibiotic	Inflammation/Immunology
Clofazimine-d₇ is deuterium labeled Clofazimine. Clofazimine is an iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial agents to treat AIDS and Crohn's disease.

HY-B1355

Oxyphenbutazone monohydrate	Bacterial COX	Infection Inflammation/Immunology
Oxyphenbutazone monohydrate is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone monohydrate is an orally active non-selective COX inhibitor. Oxyphenbutazone monohydrate selectively kills non-replicating Mycobaterium tuberculosis .

HY-N0516R

Casticin (Standard) Vitexicarpin (Standard)	Reference Standards STAT	Inflammation/Immunology
Casticin (Standard) is the analytical standard of Casticin. This product is intended for research and analytical applications. Casticin is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.

HY-122961

Dehydromiltirone 1,2-Didehydromiltirone	NF-κB p38 MAPK	Inflammation/Immunology
Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research .

HY-163547

PPAR agonist 5	PPAR	Inflammation/Immunology
PPAR agonist 5 (compound 4b) is a potent PPAR agonist with EC₅₀ values of 3.20, 1.51, 1.92 µM for PPARα, PPARβ/δ, PPARγ, respectively. PPAR agonist 5 shows anti-inflammatory effect .

HY-B1892R

Cefazolin (Standard) Cephazolin (Standard)	Reference Standards Antibiotic Bacterial	Infection Neurological Disease Inflammation/Immunology
Cefazolin (Standard) is the analytical standard of Cefazolin. This product is intended for research and analytical applications. Cefazolin (Cephazolin) is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research . Cefazolin has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD) .

HY-128473

Valeryl salicylate Valeroyl salicylate	COX	Inflammation/Immunology
Valeryl salicylate is a potent and irreversible cyclooxygenase-1 (COX-1) inhibitor. Valeryl salicylate shows anti-inflammatory effect .

HY-117726

WAY-169916	Estrogen Receptor/ERR NF-κB	Inflammation/Immunology
WAY-169916 is a pathway-selective ligand of ER (estrogen receptor) that acts by inhibiting NF-kB transcriptional activity. WAY-169916 has potent anti-inflammatory effect .

Cat. No.	Product Name

HY-L914

Serine/Threonine Focused Covalent Fragment Library

3,208 compounds

In the research of covalent inhibitors targeting serine and threonine, scientists have found that the nucleophilicity of these hydroxyl groups is significantly enhanced due to the influence of their surrounding environment. This results in higher activity during catalytic reactions. Aspirin, which targets the non-catalytic domain serine (Ser529 in human COX1) of cyclooxygenase, exerts its anti-inflammatory effect through covalent binding. β-lactam antibiotics, which targets the catalytic domain serine of penicillin-binding proteins, interferes with bacterial cell wall synthesis.

Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 3,300 fragment molecules which can target serine and threonine residues and can be used for fragment-based covalent drug discovery.

Cat. No.	Product Name	Target	Research Area

HY-P1120

WKYMVm WKYMVm-amide; W-Peptide	Formyl Peptide Receptor (FPR) PERK Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
WKYMVm is a selective formylpeptide receptor 2 (FPR2) agonist. WKYMVm has a powerful anti-inflammatory effect that can reduce lung injury and spinal cord injury. WKYMVm ameliorates obesity by regulating lipid metabolism and leptin signaling. WKYMVm is involved in the regulation of immune cells by activating FPRs. WKYMVm can promote the chemotactic migration of immune cells and inhibit the apoptosis of phagocytes. In addition, WKYMVm may play a favorable or unfavorable role in tumors, depending on the type of tumor .

HY-P1328

TAT-14 1 Publications Verification	Keap1-Nrf2	Others
TAT-14 is a 14-mer peptide that acts as Nrf2 activator with an anti-inflammatory effect. TAT-14 has no effect on Nrf2 mRNA expression, but increases Nrf2 protein level due to targeting the Nrf2 binding site on Keap1 .

HY-P0178

LXW7	Integrin	Inflammation/Immunology
LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC₅₀ of 0.68 μM. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect .

HY-P0178A

LXW7 TFA	Integrin	Inflammation/Immunology
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC₅₀ of 0.68 μM. LXW7 TFA increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect .

HY-P1328A

TAT-14 TFA	Keap1-Nrf2	Others
TAT-14 TFA is a 14-mer peptide that acts as Nrf2 activator with an anti-inflammatory effect. TAT-14 TFA has no effect on Nrf2 mRNA expression, but increases Nrf2 protein level due to targeting the Nrf2 binding site on Keap1 .

HY-P1120A

WKYMVm TFA	Formyl Peptide Receptor (FPR) PERK Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
WKYMVm (TFA) is a selective formylpeptide receptor 2 (FPR2) agonist. WKYMVm has a powerful anti-inflammatory effect that can reduce lung injury and spinal cord injury. WKYMVm ameliorates obesity by regulating lipid metabolism and leptin signaling. WKYMVm is involved in the regulation of immune cells by activating FPRs, and WKYMVm can promote the chemotactic migration of immune cells and inhibit the apoptosis of phagocytes. In addition, WKYMVm may play a favorable or unfavorable role in tumors, depending on the type of tumor .

HY-P11241

oNCM	Bacterial	Infection Inflammation/Immunology
oNCM is an antibacterial peptide. oNCM has good antibacterial activity, anti biofilm ability, anti-inflammatory effect, high stability, and low cytotoxicity. oNCM can be used for research on infectious or inflammatory conditions .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99126

Anti-Mouse/Human CD44 Antibody (IM7) 2 Publications Verification	Transmembrane Glycoprotein CD44	Inflammation/Immunology Cancer
Anti-Mouse/Human CD44 Antibody (IM7) is an anti-huamn and mouse CD44 IgG2b monoclonal antibody that recognizes a conserved epitope outside the HA-binding domain of the CD44 molecule. Anti-Mouse/Human CD44 Antibody (IM7) exerts a potent anti-inflammatory effect by inducing the shedding of cell surface CD44, significantly improving symptoms in mice with rheumatoid arthritis without affecting relevant immune responses. Anti-Mouse/Human CD44 Antibody (IM7) can be used for researches on inflammation conditions and cancer such as arthritis and osteosarcoma .

HY-P990057

Picankibart IBI-112	Interleukin Related	Cancer
Picankibart is a human-derived IgG1κ antibody targeting IL23A. Picankibart specifically binds to the IL23 p19 subunit and exerts an anti-inflammatory effect by blocking the IL23-mediated signaling pathway.

HY-P990122

Anti-Rat IL-4 Antibody (OX-81)	Interleukin Related	Inflammation/Immunology
Anti-Rat IL-4 Antibody (OX-81) is an antibody inhibitor against rat IL-4. Anti-Rat IL-4 Antibody (OX-81) can specifically block the anti-inflammatory effect of IL-4. Anti-Rat IL-4 Antibody (OX-81) can be used for research on inflammation conditions such as experimental allergic encephalomyelitis (EAE) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113159

Docosapentaenoic acid (22n-3) Clupanodonic acid	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Amylases Glycosidase
Docosapentaenoic acid (22n-3) is a component of phospholipids. Docosapentaenoic acid 22n-3 has inhibitory activity against α-amylase and α-glucosidase, with IC₅₀s value of 17 μg/mL and 22 μg/mL, respectively. Docosapentaenoic acid 22n-3 increases cell vitality. Docosapentaenoic acid 22n-3 has a weak anti-inflammatory effect .

HY-N0516

Casticin 5+ Cited Publications Vitexicarpin	Flavonoids Tephrosia deflexa Baker Classification of Application Fields Flavones Labiatae Plants Inflammation/Immunology Disease Research Fields	STAT
Casticin is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.

HY-N2515

Ginsenoside Rk1 Maximum Cited Publications 9 Publications Verification	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	NF-κB PI3K JAK Apoptosis
Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

HY-Z0548

Methyl 3,4-dihydroxybenzoate Protocatechuic acid methyl ester; Methyl protocatechuate	Classification of Application Fields Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Inflammation/Immunology Disease Research Fields Source Classification Theaceae	Keap1-Nrf2 Apoptosis
Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect .

HY-N6804

Diammonium Glycyrrhizinate	Triterpenes Classification of Application Fields Leguminosae Terpenoids Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification Cancer	NF-κB Reactive Oxygen Species (ROS)
Diammonium glycyrrhizinate is a substance that can be extracted and purified from a traditional Chinese medicinal herb. Diammonium glycyrrhizinate has anti-inflammatory effect, resistance to biologic oxidation, membranous protection and a weak steroidal action. Diammonium glycyrrhizinate exerts protective effect by downregulating inflammation cytokines, suppressing the NF-κB pathway, and restoring superoxide dismutase. Diammonium glycyrrhizinate can be used as a hepatic protector and can therefore be studied in research for most liver diseases .

HY-112578

Betanin	Structural Classification Classification of Application Fields Metabolic Disease Beta vulgaris Linn. Plants Disease Research Fields Saccharides Monosaccharides Chenopodiaceae Source Classification	Others
Betanin has potent antioxidant and anti-inflammatory effect, that could inhibit peroxynitrite (ONOO ^-), with an IC₅₀ of 19.2 μM. Betanin is a red glycoside obtained from beets that can be used as colorant.

HY-N0802

Tenuigenin 3 Publications Verification Senegenin	Triterpenes Classification of Application Fields Terpenoids Polygalaceae Plants Polygala tenuifolia Willd. Inflammation/Immunology Disease Research Fields Source Classification	NF-κB Bacterial
Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect .

HY-N5015

Rosmanol 1 Publications Verification	Classification of Application Fields Paramacrolobium coeruleum (Taub.) J.Léonard Labiatae Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	COX
Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

HY-N0677

Dehydroandrographolide succinate 1 Publications Verification	Acanthaceae Classification of Application Fields Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification Cancer	Influenza Virus Prostaglandin Receptor Akt GSK-3
Dehydroandrographolide succinate can be extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used in research for viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect. Dehydroandrographolide succinate exerts antithrombotic effect. Dehydroandrographolide succinate significantly inhibits the platelet aggregation rate (ED₅₀ = 386.9 mg/kg) by decreasing TXB₂ levels. Dehydroandrographolide succinate mitigates muscle astrophy via the Akt/GSK3β and MuRF-1 pathways .

HY-N7630

Rehmapicrogenin	Classification of Application Fields Ketones, Aldehydes, Acids Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Inflammation/Immunology Disease Research Fields Source Classification	NO Synthase COX
Rehmapicrogenin, isolated from the root of Rehmannia glutinosa, exhibits potent anti-inflammatory effect by inhibiting iNOS, COX-2 and IL-6 .

HY-N0023

Cistanoside A	Classification of Application Fields Simple Phenylpropanols Cistanche deserticola Ma Phenols Polyphenols Orobanchaceae Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology Source Classification	NO Synthase
Cistanoside A is a phenylethanoid isolated from Cistanche deserticola, reduces NO accumulation, but shows no effect on iNOS mRNA, iNOS protein levels or iNOS activity. Anti-inflammatory effect .

HY-N6826

Asatone 3 Publications Verification	Asarum sieboldii Miq. Natural Products Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Aristolochiaceae Source Classification	NF-κB
Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways .

HY-N2556

Tirucallol	Triterpenes Classification of Application Fields Euphorbia boetica Terpenoids Euphorbiaceae Plants Disease Research Fields Inflammation/Immunology Source Classification	Others
Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages .

HY-N4134

Ciwujianoside C3	Structural Classification Acanthopanax henryi (Oliv.) Harms Classification of Application Fields Terpenoids Plants Pentacyclic Triterpenoids Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	NO Synthase
Ciwujianoside C3, an orally active and brain penetrated compound, is isolated the leaves of Acanthopanax henryi Harms. Ciwujianoside C3 has anti-inflammatory effect and can reinforces object recognition memory .

HY-N1388

Tussilagone 3 Publications Verification	Classification of Application Fields Terpenoids Sesquiterpenes Plants Compositae Inflammation/Immunology Disease Research Fields Source Classification Tephrosia purpurea (L.) Pers.	Others
Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice .

HY-N8371

Shizukaol B	Terpenoids Sesquiterpenes Chloranthaceae Plants Source Classification Chloranthus henryi Hemsl.	NO Synthase COX Interleukin Related TNF Receptor
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression .

HY-N7697A

Chitopentaose pentahydrochloride	Microorganisms Classification of Application Fields Disease Research Fields Inflammation/Immunology Saccharides Source Classification	Others
Chitopentaose pentahydrochloride is a chitosan oligosaccharide with anti-inflammatory effect. Chitopentaose pentahydrochloride is a substrate of gene encoding chitinase B (FjchiB) .

HY-N2495

Isomucronulatol	Flavonoids other families Classification of Application Fields Leguminosae Phenols Polyphenols Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Other Flavonoids Inflammation/Immunology Disease Research Fields Source Classification	Others
Isomucronulatol is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol exhibits inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect .

HY-N0406

2"-O-beta-L-galactopyranosylorientin	Flavonoids other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Isoflavones Source Classification	P-glycoprotein
2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2). Anti-inflammatory effect .

HY-N4312

Bryodulcosigenin 1 Publications Verification 11-Oxomogrol	Triterpenes other families Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Others
Bryodulcosigenin is an extract of the roots of Bryoniadioica with anti-inflammatory effect .

HY-N0516R

Casticin (Standard) Vitexicarpin (Standard)	Structural Classification Flavonoids Tephrosia deflexa Baker Flavones Labiatae Plants	Reference Standards STAT
Casticin (Standard) is the analytical standard of Casticin. This product is intended for research and analytical applications. Casticin is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.

HY-122961

Dehydromiltirone 1,2-Didehydromiltirone	Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	NF-κB p38 MAPK
Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research .

HY-N0811

Anemarsaponin B	Liliaceae Classification of Application Fields Anemarrhena asphodeloides Bunge Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	NO Synthase COX NF-κB MEK
Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

HY-N10133

Licoflavanone 3′-Prenylnaringenin	Structural Classification Glycyrrhiza glabra Linn. Flavonoids Leguminosae Flavonones Plants Source Classification	Bacterial mTOR Akt PI3K NF-κB Caspase JNK ERK COX NO Synthase Apoptosis
Licoflavanone (3′-Prenylnaringenin) is a flavanone with antioxidant, anti-inflammatory and anticancer activities. Licoflavanone can be isolated from the leaf extract of Glycyrrhiza glabra. Licoflavanone downregulates the mTOR/PI3K/AKT signaling pathway to inhibit the proliferation, migration and invasion of cancer cells, while activates Bax, Bad and multiple caspase enzymes to induce apoptosis. Its anti-inflammatory effect is manifested by reducing the nuclear translocation of NF-κB, decreasing the phosphorylation levels of p38, JNK and ERK1/2, thereby inhibiting the expression of nitric oxide, proinflammatory cytokines, COX-2 and iNOS. Licoflavanone is used in studies on nasopharyngeal carcinoma and related mechanisms .

HY-126414

Methylenedihydrotanshinquinone	Terpenoids Labiatae Diterpenoids Plants Apuleia leiocarpa (Vogel) J.F.Macbr.	Others
Methylenedihydrotanshinquinone is a natural product that can be isolated from the dried root of S. miltiorrhiza. Methylenedihydrotanshinquinone has anti-inflammatory effect by inhibiting expression of TNF-α, IL-1β, and IL-8 .

HY-N17239

Oleracone	Structural Classification Alkaloids Portulacaceae Other Alkaloids Portulaca oleracea Linn. Plants Source Classification	TNF Receptor Interleukin Related NO Synthase
Oleracone is a type of alkaloid that can be found in Portulaca oleracea L.. Oleracone exhibits a significant anti-inflammatory effect in the RAW 264.7 macrophage model induced by LPS (HY-D1056), capable of inhibiting NO production and significantly suppressing the secretion of pro-inflammatory cytokines TNF-α, IL-6, and prostaglandin E₂ (PGE₂). Oleracone can be used for the study of inflammatory diseases .

HY-N12000

Aquilarone C	Natural Products Thymelaeaceae Plants Aquilaria sinensis (Lour.) Spreng. Source Classification	Others
Aquilarone C is a chromone derivative with anti-inflammatoryeffects .

HY-N1246

Savinin (-)-Savinin	Natural Products Cupressaceae Juniperus chinensis L. Plants Source Classification	Others
Savinin is a lignan, whicn can serves as a valuable pharmacophore to exhibit anti-inflammatory effect .

HY-N3323

Mannioside A	Plants Dracaena mannii Baker Steroids Source Classification Asparagaceae Juss.	Others
Mannioside A is a steroidal saponin. Mannioside A is a nature product that could be isolated from Dracaena mannii. Mannioside A has anti-inflammatory effect .

HY-133594

Sandaracopimaric acid	Cardiovascular Disease Cupressaceae Classification of Application Fields Ketones, Aldehydes, Acids Callitris quadrivalvis Plants Disease Research Fields Source Classification	GABA Receptor
Sandaracopimaric acid is a diterpenoid with anti-inflammatory effect. Sandaracopimaric acid reduces the contraction of phenylephrine-induced pulmonary arteries with an EC₅₀ of 43.93 μM .

HY-N10809

13-Hydroxygermacrone	Terpenoids Sesquiterpenes Plants Curcuma phaeocaulis Valeton Source Classification Zingiberaceae	Others
13-Hydroxygermacrone (compound 8) is a nature product that could be isolated form Curcuma zedoaria. 13-Hydroxygermacrone has anti-inflammatory effect .

HY-N3866

Esculentic acid	Triterpenes Terpenoids Labiatae Plants Source Classification Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	COX
Esculentic acid is a selective COX-2 inhibitor and has anti-inflammatory effect. Esculentic acid is a pentacyclic triterpenoid that can be extracted from the Chinese herb Phytolacca esculenta .

HY-N1546

Protoplumericin A	Apocynaceae Structural Classification Iridoids Allamanda schottii Terpenoids Plants Source Classification	Others
Protoplumericin A is a bioactive ingredient of Plumeria obtusa L. attenuates. Protoplumericin A mitigated lipopolysaccharide (LPS) -induced acute lung injury in mice. Protoplumericin A can be used to study the LPS-induced anti-inflammatory effect .

HY-N15077

11-Deacetoxywortmannin	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
11-Deacetoxywortmannin is an antibiotic found in Aspergillus janus NRRL 3807 and Penicillum funiculosum NRRL 3363. 11-Deacetoxywortmannin has a strong anti-fungal and anti-inflammatory effect, and has an anti-edema effect .

HY-N1782

3,4-O-Isopropylidene-shikimic acid	other families Classification of Application Fields Ketones, Aldehydes, Acids Plants Inflammation/Immunology Disease Research Fields Source Classification	Others
3,4-O-Isopropylidene-shikimicn acid is a natural product that can be isolated from the whole plants of Hypericum wightianum. 3,4-O-Isopropylidene-shikimic acid has anti-inflammatory effect and antioxidant activities .

HY-N5015R

Rosmanol (Standard)	Paramacrolobium coeruleum (Taub.) J.Léonard Labiatae Phenols Polyphenols Plants Source Classification	Reference Standards COX
Rosmanol (Standard) is the analytical standard of Rosmanol. This product is intended for research and analytical applications. Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

HY-N3261

Methyllinderone	Flavonoids Lindera erythrocarpa Makino Plants Lauraceae Other Flavonoids Source Classification	AP-1 ERK STAT
Methyllinderone is an inhibitor of AP-1/STAT/ERK. Methyllinderone has anti-inflammatory effect. Methyllinderone reduce the invasion and migration rate of TPA-stimulated MCF-7 cells. Methyllinderone can be used in study breast cancer metastasis .

HY-N12101

Anti-inflammatory agent 57	Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Plants Umbelliferae Source Classification	Others
Anti-inflammatory agent 57 (Compound 13), pyranocoumarin, is a nature product. Anti-inflammatory agent 57 can be isolated from the roots of Peucedanum praeruptorum. Anti-inflammatory agent 57 has multidrug-resistance (MDR) reversal and anti-inflammatory effect .

HY-124508

Lambertellin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial Fungal p38 MAPK NF-κB
Lambertellin is an effective antibiotic that can be used as a bactericide and as a fungicide. Lambertellin exerts its anti-inflammatory effect in LPS (HY-D1056)-stimulated RAW 264.7 macrophage cells by modulating the activation of the MAPK and NF-κB signaling pathways .

HY-113345R

Zymostenol (Standard) 5a-Cholest-8-en-3b-ol (Standard)	Microorganisms Source Classification	Reference Standards Endogenous Metabolite ROR
Oxyphenbutazone (monohydrate) (Standard) is the analytical standard of Oxyphenbutazone (monohydrate). This product is intended for research and analytical applications. Oxyphenbutazone monohydrate is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone monohydrate is an orally active non-selective COX inhibitor. Oxyphenbutazone monohydrate selectively kills non-replicating Mycobaterium tuberculosis .

HY-N0802R

Tenuigenin (Standard) Senegenin (Standard)	Triterpenes Structural Classification Terpenoids Polygalaceae Plants Polygala tenuifolia Willd. Source Classification	Reference Standards NF-κB Bacterial
Tenuigenin (Standard) is the analytical standard of Tenuigenin. This product is intended for research and analytical applications. Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect .

HY-Z0548R

Methyl 3,4-dihydroxybenzoate (Standard) Protocatechuic acid methyl ester (Standard); Methyl protocatechuate (Standard)	Structural Classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Reference Standards Keap1-Nrf2 Apoptosis
Methyl 3,4-dihydroxybenzoate (Standard) is the analytical standard of Methyl 3,4-dihydroxybenzoate. This product is intended for research and analytical applications. Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect .

HY-N3548

Catalpalactone	Natural Products Catalpa ovata G. Don Plants Bignoniaceae Source Classification	NF-κB
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .

HY-N1388R

Tussilagone (Standard)	Structural Classification Terpenoids Sesquiterpenes Plants Compositae Source Classification Tephrosia purpurea (L.) Pers.	Reference Standards Others
Tussilagone (Standard) is the analytical standard of Tussilagone. This product is intended for research and analytical applications. Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice .

HY-N0406R

2"-O-beta-L-galactopyranosylorientin (Standard)	Structural Classification Flavonoids other families Plants Isoflavones Source Classification	Reference Standards Others
2"-O-beta-L-galactopyranosylorientin (Standard) is the analytical standard of 2"-O-beta-L-galactopyranosylorientin. This product is intended for research and analytical applications. 2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2). Anti-inflammatory effect .

HY-N11723

Catenarin Katenarin	Quinones Microorganisms Anthraquinones Source Classification	CCR CXCR p38 MAPK JNK Calcium Channel
Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice ^[1][2].

HY-N2515R

Ginsenoside Rk1 (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Plants Araliaceae Source Classification	Reference Standards NF-κB PI3K JAK Apoptosis
Ginsenoside Rk1 (Standard) is the analytical standard of Ginsenoside Rk1. This product is intended for research and analytical applications. Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

Cat. No.	Product Name	Chemical Structure

HY-B1892S1

Cefazolin-13C2,15N
Cefazolin- ¹³C₂, ¹⁵N (Cephazolin- ¹³C₂, ¹⁵N) is ¹³C and ¹⁵N labeled Cefazolin. Cefazolin (Cephazolin) is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research . Cefazolin has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD) .

HY-B1046S

Clofazimine-d7
Clofazimine-d₇ is deuterium labeled Clofazimine. Clofazimine is an iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial agents to treat AIDS and Crohn's disease.

HY-W654098

Cefazolin-13C2,15N sodium
Cefazolin- ¹³C₂, ¹⁵N (sodium) is ¹³C and ¹⁵N labeled Cefazolin (sodium). Cefazolin sodium is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research . Cefazolin sodium has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD).

HY-B1322AS

Amodiaquine-d10
Amodiaquine-d₁₀ is the deuterium labeled Amodiaquine. Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect .

HY-Z0548S1

Methyl 3,4-dihydroxybenzoate-d3-1
Methyl 3,4-dihydroxybenzoate-d₃-1 is the deuterium labeled Methyl 3,4-dihydroxybenzoate. Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect .

HY-B1355AS

Oxyphenbutazone-d9
Oxyphenbutazone-d₉ is the deuterium labeled Oxyphenbutazone (HY-B1355A). Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is the metabolite of Phenylbutazone (HY-B0230). Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis .

HY-B1355AS1

Oxyphenbutazone-13C6
Oxyphenbutazone- ¹³C₆ is the ¹³C₆ labeled Oxyphenbutazone (HY-B1355A). Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is the metabolite of Phenylbutazone (HY-B0230). Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis .

HY-B1322AS1

Amodiaquine-d10 hydrochloride
Amodiaquine-d₁₀ hydrochloride is deuterated labeled Amodiaquine (HY-B1322A). Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect .

Cat. No.	Product Name		Classification

HY-177800

ARC5690 sodium		Aptamers
ARC5690 sodium is an anti-mouse P-selectin aptamer. ARC5690 bound to recombinant mouse P-selectin with a KD of approximately 15pM in vitro. ARC5690 showed a significant anti-inflammatory effect

HY-177809

aptTNF-α sodium		Aptamers
aptTNF-α sodium is a TNF-α-targeting aptamer that has tissue protective effect and systemic anti-inflammatory effect upon acute tissue injury using the mouse acute lung injury (ALI) and acute liver failure (ALF) models.

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