Licoflavanone  (Synonyms: 3′-Prenylnaringenin)

Licoflavanone (3′-Prenylnaringenin) is a flavanone with antioxidant, anti-inflammatory and anticancer activities. Licoflavanone can be isolated from the leaf extract of Glycyrrhiza glabra. Licoflavanone downregulates the mTOR/PI3K/AKT signaling pathway to inhibit the proliferation, migration and invasion of cancer cells, while activates Bax, Bad and multiple caspase enzymes to induce apoptosis. Its anti-inflammatory effect is manifested by reducing the nuclear translocation of NF-κB, decreasing the phosphorylation levels of p38, JNK and ERK1/2, thereby inhibiting the expression of nitric oxide, proinflammatory cytokines, COX-2 and iNOS. Licoflavanone is used in studies on nasopharyngeal carcinoma and related mechanisms^[1][2].

Licoflavanone (12.5-100 μM; 24 h) reduces the viability of human nasopharyngeal carcinoma HK1 cells in a concentration-dependent manner^[1].
Licoflavanone (12.5-100 μM; 72 h) induces destructive morphological changes and apoptosis in human nasopharyngeal HK1 cancer cells following 72 h of treatment at concentrations of 12.5, 25, and 100 μM^[1].
Licoflavanone (12.5-100 μM; 24 h) regulates the expression of apoptosis-related proteins, upregulates pro-apoptotic proteins and downregulates anti-apoptotic proteins in human nasopharyngeal HK1 cancer cells following 24 h of treatment at concentrations of 12.5, 25 and 100 μM^[1].
Licoflavanone (12.5-100 μM; 24 h) inhibits the mTOR/PI3K/AKT pathway in human nasopharyngeal carcinoma HK1 cells in a concentration-dependent manner by downregulating the expression of phosphorylated mTOR, PI3K and AKT (treatment concentrations: 12.5, 25 and 100 μM, treatment duration: 24 h)^[1].
Licoflavanone (12.5-100 μM; 24 h) inhibits the migration and invasion of human nasopharyngeal HK1 cancer cells in a concentration-dependent manner^[1].
Licoflavanone inhibits NO production in LPS-stimulated RAW 264.7 mouse macrophages with an IC₅₀ of 37.68 μM, and suppresses the phosphorylation and activation of p38, JNK and ERK1/2 MAPKs^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

340.37

C₂₀H₂₀O₅

119240-82-3

O=C1C[C@@H](C2=CC=C(O)C(C/C=C(C)\C)=C2)OC3=CC(O)=CC(O)=C13

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu J, et al. Licoflavanone exerts anticancer effects on human nasopharyngeal cancer cells via caspase activation, suppression of cell migration and invasion, and inhibition of m-TOR/PI3K/AKT pathway[J]. Tropical Journal of Pharmaceutical Research, 2021, 20(7): 1387-1393.

  [2]. Frattaruolo L, et al. Antioxidant and anti-inflammatory activities of flavanones from Glycyrrhiza glabra L.(licorice) leaf phytocomplexes: Identification of licoflavanone as a modulator of NF-kB/MAPK pathway[J]. Antioxidants, 2019, 8(6): 186.

  [3]. Hongxia G, et al. Licoflavone A Suppresses Gastric Cancer Growth and Metastasis by Blocking the VEGFR‐2 Signaling Pathway[J]. Journal of Oncology, 2022, 2022(1): 5497991.

  [4]. Liu F, et al. The effects of Licoflavone on hepatic lipid accumulation: In vitro and in vivo studies[J]. Food Bioscience, 2025, 66: 106241.