119240-82-3
Chemical Structure
Licoflavanone
Synonym(s): 3′-Prenylnaringenin
- CAS No.: 119240-82-3
- Formula:C20H20O5
- Molecular Weight:340.37
IUPAC Name: (S)-5,7-dihydroxy-2-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)chroman-4-one
InChIKey: CGKWSLSAYABZTL-SFHVURJKSA-N
SMILES: O=C1C[C@@H](C2=CC=C(O)C(C/C=C(C)\C)=C2)OC3=CC(O)=CC(O)=C13
Biological Activity:
Licoflavanone (3′-Prenylnaringenin) is a flavanone with antioxidant, anti-inflammatory and anticancer activities. Licoflavanone can be isolated from the leaf extract of Glycyrrhiza glabra. Licoflavanone downregulates the mTOR/PI3K/AKT signaling pathway to inhibit the proliferation, migration and invasion of cancer cells, while activates Bax, Bad and multiple caspase enzymes to induce apoptosis. Its anti-inflammatory effect is manifested by reducing the nuclear translocation of NF-κB, decreasing the phosphorylation levels of p38, JNK and ERK1/2, thereby inhibiting the expression of nitric oxide, proinflammatory cytokines, COX-2 and iNOS. Licoflavanone is used in studies on nasopharyngeal carcinoma and related mechanisms[1][2].
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Licoflavanone | Licoflavanone (3′-Prenylnaringenin) is a flavanone with antioxidant, anti-inflammatory and anticancer activities. Licoflavanone can be isolated from the leaf extract of Glycyrrhiza glabra. Licoflavanone downregulates the mTOR/PI3K/AKT signaling pathway to inhibit the proliferation, migration and invasion of cancer cells, while activates Bax, Bad and multiple caspase enzymes to induce apoptosis. Its anti-inflammatory effect is manifested by reducing the nuclear translocation of NF-κB, decreasing the phosphorylation levels of p38, JNK and ERK1/2, thereby inhibiting the expression of nitric oxide, proinflammatory cytokines, COX-2 and iNOS. Licoflavanone is used in studies on nasopharyngeal carcinoma and related mechanisms. |
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References
- [1]. Liu J, et al. Licoflavanone exerts anticancer effects on human nasopharyngeal cancer cells via caspase activation, suppression of cell migration and invasion, and inhibition of m-TOR/PI3K/AKT pathway[J]. Tropical Journal of Pharmaceutical Research, 2021, 20(7): 1387-1393.
- [2]. Frattaruolo L, et al. Antioxidant and anti-inflammatory activities of flavanones from Glycyrrhiza glabra L.(licorice) leaf phytocomplexes: Identification of licoflavanone as a modulator of NF-kB/MAPK pathway[J]. Antioxidants, 2019, 8(6): 186.
