Butamirate citrate
Based on 1 Customer Validation
Butamirate citrate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate citrate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate citrate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate citrate can be used for the study of glioblastoma.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 18109-81-4
- Formula: C24H37NO10
- Molecular Weight:499.55
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Butamirate citrate (0.01-10 μM; 7 days) could effectively suppress sphere formation and STAT3 activity[2].
Butamirate citrate effectively inhibits interactions of RRAD with pSTAT3[2].
Butamirate citrate shows decreased EGFR, STAT3, ERK and AKT phosphorylation in U87MG[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U87MG, U87MG-TMZ-resistant (U87 TMZR), U87MG-Lapatinib-resistant (U87 LAPAR) and T98G (TMZ resistant) tumorspheres
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Concentration:0.01-10 μM
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Incubation Time:7 days
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Result:Effectively suppressed growth of glioblastoma cell lines, including U87MG-TMZR and U87MG-LAPAR.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male BALB/c nude mice (6- to 8 week-old) were subcutaneously injected with U87MG cells[2]
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Dosage:2 mg/kg
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Administration:i.p; once a day; for 36 days.
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Result:Inhibited tumor growth in a glioblastoma mouse xenograft model.
Chemical Information
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CAS No. 18109-81-4
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Appearance Solid
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Molecular Weight 499.55
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Formula C24H37NO10
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Color White to off-white
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SMILES
O=C(OCCOCCN(CC)CC)C(CC)C1=CC=CC=C1.O=C(CC(C(O)=O)(O)CC(O)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 125 mg/mL (250.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Płusa T. [Butamirate citrate in control of cough in respiratory tract inflammation]. Pol Merkur Lekarski. 2017 Aug 21;43(254):69-74. Polish. [Content Brief]
[2]. Lee SJ, et al. Application of the antitussive agents oxelaidin and butamirate as anti-glioma agents. Sci Rep. 2021 May 12;11(1):10145. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0018 mL | 10.0090 mL | 20.0180 mL | 50.0450 mL |
| 5 mM | 0.4004 mL | 2.0018 mL | 4.0036 mL | 10.0090 mL | |
| 10 mM | 0.2002 mL | 1.0009 mL | 2.0018 mL | 5.0045 mL | |
| 15 mM | 0.1335 mL | 0.6673 mL | 1.3345 mL | 3.3363 mL | |
| 20 mM | 0.1001 mL | 0.5005 mL | 1.0009 mL | 2.5023 mL | |
| 25 mM | 0.0801 mL | 0.4004 mL | 0.8007 mL | 2.0018 mL | |
| 30 mM | 0.0667 mL | 0.3336 mL | 0.6673 mL | 1.6682 mL | |
| 40 mM | 0.0500 mL | 0.2502 mL | 0.5005 mL | 1.2511 mL | |
| 50 mM | 0.0400 mL | 0.2002 mL | 0.4004 mL | 1.0009 mL | |
| 60 mM | 0.0334 mL | 0.1668 mL | 0.3336 mL | 0.8341 mL | |
| 80 mM | 0.0250 mL | 0.1251 mL | 0.2502 mL | 0.6256 mL | |
| 100 mM | 0.0200 mL | 0.1001 mL | 0.2002 mL | 0.5005 mL |
Butamirate citrate Related Classifications
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