Search Result

Results for "

decarboxylase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Decarboxylase (12) Malonyl-CoA Decarboxylase (1) Ornithine decarboxylase (ODC) (4) 5-HT Receptor (6) Acetyl-CoA Carboxylase (1) Adrenergic Receptor (1) Akt (1) Amyloid-β (5) Apoptosis (9) Aryl Hydrocarbon Receptor (7) Autophagy (13) Bacterial (10) Bcl-2 Family (2) Biochemical Assay Reagents (11) Caspase (2) CCR (2) CDK (1) Cholecystokinin Receptor (1) COMT (1) DNA/RNA Synthesis (1) Dopamine Receptor (1) Drug Derivative (7) Drug Intermediate (1) Drug Isomer (2) Drug Metabolite (11) Endogenous Metabolite (41) Environmental Pollutants (2) ERK (5) Fructose-1,6-bisphosphate aldolase (1) GABA Receptor (7) GLP Receptor (2) HCV (1) Herbicide (1) HIV (2) Influenza Virus (1) Insulin Receptor (2) Interleukin Related (2) Isotope-Labeled Compounds (11) KMO (1) MHC (1) Microtubule/Tubulin (1) Monoamine Oxidase (1) NF-κB (3) Nucleoside Antimetabolite/Analog (1) p38 MAPK (2) PAK (1) Parasite (7) PKC (2) Pyruvate Kinase (4) RAR/RXR (1) Reactive Oxygen Species (ROS) (2) Reference Standards (20) Transketolase (1) Tryptophan Hydroxylase (1) Virus Protease (1) α-synuclein (2) β-glucuronidase (1)
By Research Areas:	Cancer (48) Cardiovascular Disease (3) Infection (17) Inflammation/Immunology (15) Metabolic Disease (51) Neurological Disease (48)
Oligonucleotides:	Nucleotide Analogs (1) Uracil Nucleotide (1)

133

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Amino Acid Decarboxylase Ornithine decarboxylase (ODC) Malonyl-CoA Decarboxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0744

Eflornithine Maximum Cited Publications 21 Publications Verification DFMO; MDL71782; RMI71782; α-difluoromethylornithine	Parasite	Infection Cancer
Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

HY-B0744B

Eflornithine hydrochloride hydrate Maximum Cited Publications 21 Publications Verification DFMO hydrochloride hydrate; MDL-71782 hydrochloride hydrate; RMI-71782 hydrochloride hydrate; α-difluoromethylornithine hydrochloride hydrate	Parasite	Cancer
Eflornithine hydrochloride hydrate (DFMO hydrochloride hydrate) is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine hydrochloride hydrate is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women .

HY-N0122

5-Hydroxytryptophan 2 Publications Verification 5-HTP; DL-5-Hydroxytryptophan	Endogenous Metabolite 5-HT Receptor	Neurological Disease Metabolic Disease
5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .

HY-N0384

Homovanillic acid Vanilacetic acid	Drug Metabolite Endogenous Metabolite Autophagy	Metabolic Disease
Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency .

HY-B0404A

Benserazide hydrochloride 5+ Cited Publications Ro 4-4602 hydrochloride	Pyruvate Kinase	Neurological Disease Cancer
Benserazide hydrochloride (Serazide) is an *aromatic L-amino acid decarboxylase* (AADC)** and L-DOPA decarboxylase inhibitor. Benserazide hydrochloride is also a PKM2 inhibitor. Benserazide hydrochloride directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide hydrochloride can be used for the study of Parkinson's disease and melanoma .

HY-B0311

Carbidopa 2 Publications Verification (S)-(-)-Carbidopa	Aryl Hydrocarbon Receptor	Neurological Disease Cancer
Carbidopa ((S)-(-)-Carbidopa), a peripheral *decarboxylase* inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .

HY-Y0367

Maleic acid 1 Publications Verification	Environmental Pollutants Endogenous Metabolite Bacterial	Infection
Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of *E. coli* and *L. monocytogenes*.

HY-N0575

Pinocembrin Maximum Cited Publications 12 Publications Verification (+)-Pinocoembrin; Dihydrochrysin; Galangin flavanone	Bacterial Reactive Oxygen Species (ROS) Autophagy	Infection Inflammation/Immunology Cancer
Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties .

HY-N0240

Herbacetin 5 Publications Verification	Ornithine decarboxylase (ODC)	Cancer
Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects . Herbacetin is an *Ornithine decarboxylase* (ODC)** allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis .

HY-111365

TES-1025 3 Publications Verification	KMO	Metabolic Disease
TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC₅₀ of 13 nM .

HY-W016814

(Z)-Aconitic acid 1 Publications Verification cis-Aconitic acid	Endogenous Metabolite Amino Acid Decarboxylase	Metabolic Disease Inflammation/Immunology
(Z)-Aconitic acid is an orally active glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .

HY-B0744A

Eflornithine hydrochloride Maximum Cited Publications 21 Publications Verification DFMO hydrochloride; MDL71782 hydrochloride; RMI71782 hydrochloride; α-difluoromethylornithine hydrochloride	Parasite	Infection Cancer
Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

HY-106634

Mitoguazone 5 Publications Verification Methylglyoxal-bis(guanylhydrazone); MGBG; Methyl-GAG	HIV Apoptosis	Infection Cancer
Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive *S-adenosyl-methionine decarboxylase* (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV** DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment .

HY-13746B

Sardomozide dihydrochloride 5+ Cited Publications CGP 48664A	Apoptosis	Cancer
Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC₅₀ of 5 nM.

HY-W019599

4-Chloro-L-phenylalanine L-PCPA	5-HT Receptor Tryptophan Hydroxylase	Neurological Disease
4-Chloro-L-phenylalanine (L-PCPA) is a tryptophan hydroxylase inhibitor targeting TPH1 and TPH2, with the activity of blocking serotonin biosynthesis. 4-Chloro-L-phenylalanine reduces the levels of serotonin and its metabolites in the brain without impairing the survival of serotonergic neurons. 4-Chloro-L-phenylalanine enhances anhedonic, depression-like and anxiety-like behaviors in mice with depleted noradrenergic and dopaminergic neurons. 4-Chloro-L-phenylalanine acts as a decarboxylation substrate for aromatic L-amino acid decarboxylase from Bacillus atrophaeus. 4-Chloro-L-phenylalanine can be used in studies related to Parkinson's disease .

HY-121275

Benserazide 5+ Cited Publications Ro 4-4602	Pyruvate Kinase	Neurological Disease Cancer
Benserazide is an *aromatic L-amino acid decarboxylase* (AADC)** and L-DOPA decarboxylase inhibitor. Benserazide is also a PKM2 inhibitor. Benserazide directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide can be used for the study of Parkinson's disease and melanoma .

HY-W012906

L-Allylglycine 1 Publications Verification L-2-Allylglycine	Amino Acid Decarboxylase GABA Receptor	Neurological Disease
L-Allylglycine (L-2-Allylglycine) is an amino acid derivative. L-Allylglycine is an inhibitor for *glutamate decarboxylase* (GAD)** that reduces the GABA biosynthesis in the brain. L-Allylglycine exhibits convulsant activity .

HY-B0311A

Carbidopa monohydrate 2 Publications Verification (S)-(-)-Carbidopa monohydrate	Aryl Hydrocarbon Receptor	Neurological Disease Cancer
Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral *decarboxylase* inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth .

HY-B1537

Azaribine 2',3',5'-Tri-O-acetyl-6-azauridine	Virus Protease Influenza Virus	Infection Inflammation/Immunology
Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent *orotidine monophosphate decarboxylase* (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity (EC₅₀=3.80 nM-1.73 μM against influenza A and B viruses; EC₅₀**=1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research .

HY-W016349

Chelidamic acid	Amino Acid Decarboxylase	Others
Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a K_i of 33 μM.

HY-113468

3-O-Methyl-DL-DOPA 3-Methoxytyrosine	Endogenous Metabolite	Neurological Disease
3-O-Methyl-DL-DOPA is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Epilepsy, Purine Nucleoside Phosphorylase Deficiency and Aromatic L Amino Acid Decarboxylase Deficiency .

HY-W041489

Chelidonic acid 1 Publications Verification	NF-κB Caspase	Inflammation/Immunology Cancer
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 . Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

HY-E70518

*Oxalate decarboxylase, Microorganism*	Bacterial	Infection
Oxalate decarboxylase, Microorganism (EC 4.1.1.2), a stress-response enzyme in certain soil bacteria, is a Mn-dependent enzyme in the cupin superfamily and is found in fungi and soil bacteria. Oxalate decarboxylase catalyzes the decarboxylation of the oxalate mono-anion in the soil bacterium Bacillus subtilis. Enzymatic activity of OxDC is strongly pH dependent, with a maximum at around pH 4.0 .

HY-132822

Ivospemin SBP-101	Drug Derivative	Cancer
Ivospemin (SBP-101) is an antineoplastic spermine analog. Ivospemin has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin is promising for research of cancers .

HY-100983

Protein kinase inhibitor H-7 dihydrochloride	PKC	Cancer
Protein kinase inhibitor H-7 dihydrochloride is a potent PKC (protein kinase C) inhibitor. At 100 μM, Protein kinase inhibitor H-7 dihydrochloride completely inhibits both TPA (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase) .

HY-109131

Foscarbidopa ABBV-951; Carbidopa 4′-monophosphate	Aryl Hydrocarbon Receptor Drug Metabolite	Neurological Disease
Foscarbidopa (ABBV-951; Carbidopa 4′-monophosphate) is an inhibitory prodrug targeting peripheral aromatic L-amino acid *decarboxylase*. Foscarbidopa is hydrolyzed into Carbidopa (HY-B0311) by phosphatases in vivo to suppress peripheral metabolism of levodopa and elevate brain delivery of levodopa. Foscarbidopa can be used for the research of Parkinson’s disease and advanced Parkinson’s disease .

HY-112619

TES-991 1 Publications Verification	Amino Acid Decarboxylase	Metabolic Disease
TES-991 is a potent and selective human α Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) inhibitor, with an IC₅₀ of 3 nM.

HY-115822

α-Fluoromethylhistidine dihydrochloride	Amino Acid Decarboxylase	Neurological Disease Metabolic Disease
α-Fluoromethylhistidine dihydrochloride is an orally active histidine decarboxylase inhibitor. α-Fluoromethylhistidine dihydrochloride depletes histamine in enterochromaffin-like (ECL) cells, reduces the number and volume density of secretory vesicles in ECL cells, and does not affect histamine storage in mast cells. α-Fluoromethylhistidine dihydrochloride abolishes Omeprazole (HY-B0113)-induced vacuolization of ECL cells and decreases gastrin-induced histamine efflux from ECL cells. α-Fluoromethylhistidine dihydrochloride does not alter the granular characteristics of ECL cells, omeprazole-induced hypertrophy of ECL cells, gastrin-induced pancreastatin-like immunoreactivity efflux, nor does it affect gastric acid secretion induced by histamine or vagal stimulation. α-Fluoromethylhistidine dihydrochloride inhibits basal and gastrin-stimulated gastric acid secretion, reduces acid output induced by gastrin+IBMX (HY-12318), but does not directly affect acid generation in isolated parietal cells .

HY-B0744D

L-Eflornithine monohydrochloride L-DFMO monohydrochloride; ; L-RMI71782 monohydrochloride; L-α-difluoromethylornithine monohydrochloride	Parasite	Cancer
L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a K_D of 1.3±0.3 µM, and a K_inact of 0.15±0.03 min ^-1 .

HY-W003445

4-Bromo-3-hydroxybenzoic acid	Endogenous Metabolite	Neurological Disease
4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a *histidine decarboxylase* (HDC) inhibitor with IC₅₀s of 1 mM for both rat fetal and rat gastric HDC*. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase* from hog kidney and rat gastric mucosa in vitro with IC₅₀s of 1 mM for both enzymes .

HY-103355

YM022 2 Publications Verification	CCR	Metabolic Disease
YM022 is a highly potent, selective and orally active gastrin/cholecystokinin (CCK)-B receptor (CCK-BR) antagonist. YM022 shows the K_i values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively . YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo .

HY-13746

Sardomozide 5+ Cited Publications CGP 48664; SAM-486A	Apoptosis	Cancer
Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC₅₀ of 5 nM.

HY-W016729

4-(Dimethylamino)cinnamaldehyde 1 Publications Verification	Biochemical Assay Reagents	Others
4-(Dimethylamino)cinnamaldehyde is a reagent used for determining indole products of tryptophan decarboxylase and tryptophanase, and can also be used for quantifying proanthocyanidins in cranberry powder.

HY-W015595

L-Allylglycine hydrochloride 1 Publications Verification L-2-Allylglycine hydrochloride	Amino Acid Decarboxylase GABA Receptor	Neurological Disease
L-Allylglycine (L-2-Allylglycine) hydrochloride is an amino acid derivative. L-Allylglycine hydrochloride is an inhibitor for *glutamate decarboxylase* (GAD)** that reduces the GABA biosynthesis in the brain. L-Allylglycine hydrochloride exhibits convulsant activity .

HY-N0384S2

Homovanillic acid-d5 Vanilacetic acid-d₅	Isotope-Labeled Compounds Autophagy Endogenous Metabolite Drug Metabolite	Neurological Disease Metabolic Disease
Homovanillic acid-d₅ (Vanilacetic acid-d₅) is the deuterium labeled Homovanillic acid (HY-N0384). Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency .

HY-115685

3-Methyl-GABA	GABA Receptor	Neurological Disease
3-Methyl-GABA is a potent GABA aminotransferase activator. 3-Methyl-GABA can fit the binding pocket of GABA_A receptor (GABAaR). 3-Methyl-GABA can activate L-glutamic acid decarboxylase (GAD). 3-Methyl-GABA has anticonvulsant activity .

HY-P2796

Pyruvate decarboxylase PDC	Biochemical Assay Reagents	Metabolic Disease
Pyruvate decarboxylase (PDC) is an enzyme that catalyses the decarboxylation of pyruvic acid to acetaldehyde. Pyruvate decarboxylase catalyses the non-oxidative conversion of pyruvate (or other 2-oxo acids) to acetaldehyde and CO₂ .

HY-N3394

Lecanoric acid	Others	Infection
Lecanoric acid is a histidine-decarboxylase inhibitor isolated from fungus. The inhibition by lecanoric acid is competitive with histidineand noncompetitive with pyridoxal phosphate. Lecanoric acid did not inhibit aromatic amino acid decarboxylase .

HY-133957

Fluoromevalonate 6-Fluoromevalonate; FMev	Biochemical Assay Reagents	Others
6-Fluoromevalonate is a mevalonate-pyrophosphate decarboxylase inhibitor.

HY-W023493

DL-Allylglycine 2-Aminopent-4-enoic acid	Amino Acid Decarboxylase	Neurological Disease
DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine significantly increases mouse brain ornithine decarboxylase (ODC) activity and decreases S-adenosyl-L-methionine decarboxylase (SAM-DC) activity. DL-Allylglycine causes a marked decrease in brain GABA concentration. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures .

HY-W1015419

α-FMH α-Fluoromethylhistidine	Amino Acid Decarboxylase	Cardiovascular Disease Neurological Disease
α-FMH (α-Fluoromethylhistidine) is an orally active histidine decarboxylase inhibitor. α-FMH depletes histamine in enterochromaffin-like (ECL) cells, reduces the number and volume density of secretory vesicles in ECL cells, and does not affect histamine storage in mast cells. α-FMH abolishes Omeprazole (HY-B0113)-induced vacuolization of ECL cells and decreases gastrin-induced histamine efflux from ECL cells. α-FMH does not alter the granular characteristics of ECL cells, omeprazole-induced hypertrophy of ECL cells, gastrin-induced pancreastatin-like immunoreactivity efflux, nor does it affect gastric acid secretion induced by histamine or vagal stimulation. α-FMH inhibits basal and gastrin-stimulated gastric acid secretion, reduces acid output induced by gastrin+IBMX (HY-12318), but does not directly affect acid generation in isolated parietal cells .

HY-125748

CBM-301940 1 Publications Verification	Malonyl-CoA Decarboxylase	Cardiovascular Disease
CBM-301940 (compound 5) is an orally active malonate CoA decarboxylase (MCD) inhibitor with IC₅₀ value of 23 nM. CBM-301940 can be used in the study of cardiovascular diseases .

HY-N15001

Gabaculine	GABA Receptor	Neurological Disease
Gabaculine is an amino acid neurotoxin and blood-brain barrier-permeable GABA transaminase inhibitor, with an IC₅₀ of 1 μM in beef and Pseudomonas ovalis. Gabaculine elevates endogenous synaptic and brain GABA levels and enhances GABA activity. Gabaculine induces sedation, hypothermia, loss of righting reflex, and prevents convulsions in mice. Gabaculine is applicable to research related to neurological disorders .

HY-N0384R

Homovanillic acid (Standard) Vanilacetic acid (Standard)	Reference Standards Autophagy Endogenous Metabolite Drug Metabolite	Neurological Disease Metabolic Disease
Homovanillic acid (Standard) (Vanilacetic acid (Standard)) is the analytical standard of Homovanillic acid (HY-N0384). This product is intended for research and analytical applications. Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency .

HY-P2825

*Tyrosine decarboxylase, Microorganism* TDC; TyrDC	Endogenous Metabolite	Others
Tyrosine decarboxylase, Microorganism (TDC) is a tyrosine decarboxylase produced by microorganisms. Tyrosine decarboxylase is a PLP-dependent enzyme that catalyzes the decarboxylation of L-tyrosine, L-phenylalanine, and L-dopa to produce tyramine, 2-phenethylamine, and dopamine, respectively. Tyrosine decarboxylase mediates acid stress resistance, maintains intracellular pH homeostasis, and generates proton motive force .

HY-164091A

Mevalonate 5-phosphate trilithium	Endogenous Metabolite	Metabolic Disease
Mevalonate 5-phosphate trilithium is a substrate of phosphomevalonate kinase and mevalonate-5-phosphate decarboxylase .

HY-113305

Dopamine 3-O-sulfate	Endogenous Metabolite	Metabolic Disease
Dopamine 3-O-sulfate mainly exists in plasma and can be used as a biomarker to characterize aromatic amino acid decarboxylase (AADC) deficiency .

HY-P5396A

GAD65 (524-543) acetate	Amino Acid Decarboxylase	Others
GAD65 (524-543) acetate is a biological active peptide with amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). GAD65 (524-543) acetate is one of the first fragments of the islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. GAD65 (524-543) acetate is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) acetate increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells .

HY-Y0367S

Maleic acid-d2 Maleic-2,3-d2 acid	Bacterial Endogenous Metabolite	Infection
Maleic Acid-d₂ is the deuterium labeled Maleic Acid . Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes .

HY-B0404AR

Benserazide hydrochloride (Standard) Ro 4-4602 hydrochloride (Standard)	Reference Standards Pyruvate Kinase	Neurological Disease Cancer
Benserazide hydrochloride (Standard) (Serazide (Standard)) is the analytical standard of Benserazide hydrochloride (HY-B0404A). This product is intended for research and analytical applications. Benserazide hydrochloride (Serazide) is an *aromatic L-amino acid decarboxylase* (AADC)** and L-DOPA decarboxylase inhibitor. Benserazide hydrochloride is also a PKM2 inhibitor. Benserazide hydrochloride directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide hydrochloride can be used for the study of Parkinson's disease and melanoma .

Cat. No.	Product Name	Target	Research Area

HY-W019599

4-Chloro-L-phenylalanine L-PCPA	5-HT Receptor Tryptophan Hydroxylase	Neurological Disease
4-Chloro-L-phenylalanine (L-PCPA) is a tryptophan hydroxylase inhibitor targeting TPH1 and TPH2, with the activity of blocking serotonin biosynthesis. 4-Chloro-L-phenylalanine reduces the levels of serotonin and its metabolites in the brain without impairing the survival of serotonergic neurons. 4-Chloro-L-phenylalanine enhances anhedonic, depression-like and anxiety-like behaviors in mice with depleted noradrenergic and dopaminergic neurons. 4-Chloro-L-phenylalanine acts as a decarboxylation substrate for aromatic L-amino acid decarboxylase from Bacillus atrophaeus. 4-Chloro-L-phenylalanine can be used in studies related to Parkinson's disease .

HY-W012906

L-Allylglycine 1 Publications Verification L-2-Allylglycine	Amino Acid Decarboxylase GABA Receptor	Neurological Disease
L-Allylglycine (L-2-Allylglycine) is an amino acid derivative. L-Allylglycine is an inhibitor for *glutamate decarboxylase* (GAD)** that reduces the GABA biosynthesis in the brain. L-Allylglycine exhibits convulsant activity .

HY-114118S1

Semaglutide-d8 tetraTFA	Isotope-Labeled Compounds GLP Receptor Insulin Receptor α-synuclein Apoptosis p38 MAPK Autophagy Bcl-2 Family	Neurological Disease Metabolic Disease Cancer
Semaglutide-d₈ tetraTFA is the deuterium labeled Semaglutide (HY-114118). Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .

HY-114118S

Semaglutide-d8	Isotope-Labeled Compounds GLP Receptor Insulin Receptor α-synuclein Apoptosis p38 MAPK Autophagy Bcl-2 Family	Neurological Disease Metabolic Disease Cancer
Semaglutide-d₈ is the deuterium labeled Semaglutide (HY-114118). Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .

HY-W015595

L-Allylglycine hydrochloride 1 Publications Verification L-2-Allylglycine hydrochloride	Amino Acid Decarboxylase GABA Receptor	Neurological Disease
L-Allylglycine (L-2-Allylglycine) hydrochloride is an amino acid derivative. L-Allylglycine hydrochloride is an inhibitor for *glutamate decarboxylase* (GAD)** that reduces the GABA biosynthesis in the brain. L-Allylglycine hydrochloride exhibits convulsant activity .

HY-134161

DL-α-(Difluoromethyl)arginine	Peptides	Metabolic Disease
DL-α-(Difluoromethyl)arginine is an potent, enzyme-activated and irreversible arginine decarboxylases inhibitor. DL-α-(Difluoromethyl)arginine blocks the arginine decarboxylase activity of E.coli and Pseudomonas aeruginosa in vivo .

HY-W023493

DL-Allylglycine 2-Aminopent-4-enoic acid	Amino Acid Decarboxylase	Neurological Disease
DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine significantly increases mouse brain ornithine decarboxylase (ODC) activity and decreases S-adenosyl-L-methionine decarboxylase (SAM-DC) activity. DL-Allylglycine causes a marked decrease in brain GABA concentration. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures .

HY-P5396A

GAD65 (524-543) acetate	Amino Acid Decarboxylase	Others
GAD65 (524-543) acetate is a biological active peptide with amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). GAD65 (524-543) acetate is one of the first fragments of the islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. GAD65 (524-543) acetate is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) acetate increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells .

HY-P2525

GAD65 (206-220)	MHC	Inflammation/Immunology
GAD65 (206-220) is glutamic acid decarboxylase (GAD) 65-derived peptide, corresponding to residues 180-188. GAD65 is presented to T cells in association with I-Ag7 MHC class II molecules and a major pancreatic antigens targeted by self-reactive T cells in type I diabetes mellitus .

HY-P5396

GAD65 (524-543)	Amino Acid Decarboxylase	Others
GAD65 (524-543) is a biological active peptide with amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). GAD65 (524-543) is one of the first fragments of islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. GAD65 (524-543) is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells .

HY-P5305A

GAD65(247-266) epitope TFA	GABA Receptor	Metabolic Disease
GAD65(247-266) epitope TFA is the T cell epitopes of islet antigens，binding to I-A ^g7 (type I diabetes-associated molecule) competitively with poor affinity. GAD65 refers to Glutamic Acid Decarboxylase 65，involved in the conversion of glutamate to gamma-aminobutyric acid (GABA) .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992360

GT-002	GABA Receptor	Neurological Disease Cancer
GT-002 is a partial positive allosteric modulator targeting the α3 subtype of GABAA receptors, as well as a specific binder of tumor-associated TF-glycosylated LYPD3. GT-002 mildly enhances GABA-induced chloride currents by binding to the benzodiazepine site of GABAA receptors, thereby alleviating prefrontal hypofunction and improving cognitive, memory and social interaction abilities. GT-002 can be used in research related to schizophrenia spectrum disorders, various squamous cell carcinomas, colorectal cancer, non-small cell lung cancer, and aromatic L-amino acid decarboxylase deficiency .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0122

5-Hydroxytryptophan 2 Publications Verification 5-HTP; DL-5-Hydroxytryptophan	Monophenols Classification of Application Fields Disease markers Phenols Endocrine diseases Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite 5-HT Receptor
5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .

HY-N0384

Homovanillic acid Vanilacetic acid	Monophenols Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Phenols Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields	Drug Metabolite Endogenous Metabolite Autophagy
Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency .

HY-Y0367

Maleic acid 1 Publications Verification	Infection Structural Classification Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite Bacterial
Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of *E. coli* and *L. monocytogenes*.

HY-N0575

Pinocembrin Maximum Cited Publications 12 Publications Verification (+)-Pinocoembrin; Dihydrochrysin; Galangin flavanone	Alpinia katsumadai Hayata Classification of Application Fields Plants Flavonoids other families Animals Leguminosae Flavonones Phenols Polyphenols Pteris vittata L. Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Source Classification Zingiberaceae Cancer	Bacterial Reactive Oxygen Species (ROS) Autophagy
Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties .

HY-N0240

Herbacetin 5 Publications Verification	Flavonols Structural Classification Flavonoids Linum usitatissimum Linn. Classification of Application Fields Linaceae Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	Ornithine decarboxylase (ODC)
Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects . Herbacetin is an *Ornithine decarboxylase* (ODC)** allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis .

HY-W016814

(Z)-Aconitic acid 1 Publications Verification cis-Aconitic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Amino Acid Decarboxylase
(Z)-Aconitic acid is an orally active glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .

HY-W011727A

Pyridoxal 5'-phosphate monohydrate 4 Publications Verification Pyridoxal phosphate monohydrate	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite Amyloid-β ERK
Pyridoxal 5'-phosphate monohydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate monohydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′‐phosphate (PMP) .

HY-W011727

Pyridoxal 5'-phosphate hydrate 4 Publications Verification Pyridoxal phosphate hydrate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Amyloid-β ERK
Pyridoxal 5'-phosphate hydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate hydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .

HY-113468

3-O-Methyl-DL-DOPA 3-Methoxytyrosine	Monophenols Neurological Disease Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
3-O-Methyl-DL-DOPA is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Epilepsy, Purine Nucleoside Phosphorylase Deficiency and Aromatic L Amino Acid Decarboxylase Deficiency .

HY-W041489

Chelidonic acid 1 Publications Verification	Classification of Application Fields Chelidonium majus Ketones, Aldehydes, Acids Plants Disease Research Fields Papaveraceae Cancer Source Classification	NF-κB Caspase
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 . Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

HY-113468A

3-O-Methyldopa 1 Publications Verification 3-Methoxy-L-tyrosine; 3-O-Methyl-L-DOPA	Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Source Classification	Drug Derivative Interleukin Related
3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa has certain antidepressant and neuroprotective activities. 3-O-Methyldopa can be used in the research of nervous system diseases such as depression and Parkinson's disease .

HY-W003445

4-Bromo-3-hydroxybenzoic acid	Monophenols Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a *histidine decarboxylase* (HDC) inhibitor with IC₅₀s of 1 mM for both rat fetal and rat gastric HDC*. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase* from hog kidney and rat gastric mucosa in vitro with IC₅₀s of 1 mM for both enzymes .

HY-N3394

Lecanoric acid	Infection Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Source Classification	Others
Lecanoric acid is a histidine-decarboxylase inhibitor isolated from fungus. The inhibition by lecanoric acid is competitive with histidineand noncompetitive with pyridoxal phosphate. Lecanoric acid did not inhibit aromatic amino acid decarboxylase .

HY-N15001

Gabaculine	Structural Classification Natural Products Microorganisms Source Classification	GABA Receptor
Gabaculine is an amino acid neurotoxin and blood-brain barrier-permeable GABA transaminase inhibitor, with an IC₅₀ of 1 μM in beef and Pseudomonas ovalis. Gabaculine elevates endogenous synaptic and brain GABA levels and enhances GABA activity. Gabaculine induces sedation, hypothermia, loss of righting reflex, and prevents convulsions in mice. Gabaculine is applicable to research related to neurological disorders .

HY-N0384R

Homovanillic acid (Standard) Vanilacetic acid (Standard)	Monophenols Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Phenols Endocrine diseases Nervous System Disorder Endogenous metabolite	Reference Standards Autophagy Endogenous Metabolite Drug Metabolite
Homovanillic acid (Standard) (Vanilacetic acid (Standard)) is the analytical standard of Homovanillic acid (HY-N0384). This product is intended for research and analytical applications. Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency .

HY-N7512

Asimilobine	Infection Alkaloids Monophenols Classification of Application Fields Phenols Nelumbo nucifera Gaertn. Plants Isoquinoline Alkaloids Nymphaeaceae Disease Research Fields Source Classification	Dopamine Receptor 5-HT Receptor Parasite
Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity .

HY-113305

Dopamine 3-O-sulfate	Natural Products Classification of Application Fields Animals Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Dopamine 3-O-sulfate mainly exists in plasma and can be used as a biomarker to characterize aromatic amino acid decarboxylase (AADC) deficiency .

HY-113468AR

3-O-Methyldopa (Standard) 3-Methoxy-L-tyrosine (Standard); 3-O-Methyl-L-DOPA (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Source Classification	Drug Derivative Interleukin Related Reference Standards
3-O-Methyldopa (Standard) is the analytical standard of 3-O-Methyldopa. This product is intended for research and analytical applications. 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine .

HY-W016814R

(Z)-Aconitic acid (Standard) cis-Aconitic acid (Standard)	Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
(Z)-Aconitic acid (Standard) is the analytical standard of (Z)-Aconitic acid. This product is intended for research and analytical applications. (Z)-Aconitic acid is a glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .

HY-113468R

3-O-Methyl-DL-DOPA (Standard) 3-Methoxytyrosine (Standard)	Structural Classification Monophenols Phenols Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
3-O-Methyl-DL-DOPA (Standard) is the analytical standard of 3-O-Methyl-DL-DOPA. This product is intended for research and analytical applications. 3-O-Methyl-DL-DOPA is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Epilepsy, Purine Nucleoside Phosphorylase Deficiency and Aromatic L Amino Acid Decarboxylase Deficiency [4].

HY-N0575R

Pinocembrin (Standard) (+)-Pinocoembrin (Standard); Dihydrochrysin (Standard); Galangin flavanone (Standard)	Structural Classification Alpinia katsumadai Hayata Plants Flavonoids other families Animals Leguminosae Flavonones Phenols Polyphenols Pteris vittata L. Glycyrrhiza uralensis Fisch. Source Classification Zingiberaceae	Reference Standards Bacterial Reactive Oxygen Species (ROS) Autophagy
Pinocembrin (Standard) is the analytical standard of Pinocembrin. This product is intended for research and analytical applications. Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties .

HY-N0122R

5-Hydroxytryptophan (Standard) 5-HTP (Standard); DL-5-Hydroxytryptophan (Standard)	Structural Classification Monophenols Disease markers Phenols Endocrine diseases Amino acids Endogenous metabolite Source Classification	Endogenous Metabolite 5-HT Receptor Reference Standards
5-Hydroxytryptophan (Standard) is the analytical standard of 5-Hydroxytryptophan. This product is intended for research and analytical applications. 5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .

HY-Y0367R

Maleic acid (Standard)	Structural Classification Immune System Disorder Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Bacterial
Maleic Acid (Standard) is the analytical standard of Maleic Acid. This product is intended for research and analytical applications. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of *E. coli* and *L. monocytogenes. IC₅₀* & Target: GAD . In Vitro: The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal .

HY-N0240R

Herbacetin (Standard)	Flavonols Structural Classification Flavonoids Linum usitatissimum Linn. Linaceae Phenols Polyphenols Plants Source Classification	Reference Standards Others
Herbacetin (Standard) is the analytical standard of Herbacetin. This product is intended for research and analytical applications. Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects . Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis .

HY-N2998R

Ganoderenic acid A (Standard)	Triterpenes Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Terpenoids Plants Endogenous metabolite Source Classification	Reference Standards β-glucuronidase
Carbidopa (monohydrate) (Standard) is the analytical standard of Carbidopa (monohydrate). This product is intended for research and analytical applications. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth .

HY-N8060

Orotidine 5′-monophosphate Orotidine monophosphate; Orotidylic acid	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Orotidine 5′-monophosphate is a pyrimidine ribonucleoside and plays a role as an endogenous metabolite of human, E. coli or mouse. Orotidine 5′-monophosphate is an intermediate in the biosynthesis of?uridine monophosphate (UMP). Orotidine 5′-monophosphate can be used for the study of mechanism of orotidine 5′-monophosphate decarboxylase .

HY-N3548

Catalpalactone	Natural Products Catalpa ovata G. Don Plants Bignoniaceae Source Classification	NF-κB
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .

HY-W041489R

Chelidonic acid (Standard)	Structural Classification Chelidonium majus Ketones, Aldehydes, Acids Plants Papaveraceae Source Classification	Reference Standards NF-κB Caspase
Chelidonic acid (Standard) is the analytical standard of Chelidonic acid. This product is intended for research and analytical applications. Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 . Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM .

HY-W011727AR

Pyridoxal 5'-phosphate monohydrate (Standard) Pyridoxal phosphate monohydrate (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Amyloid-β ERK
Pyridoxal 5'-phosphate (monohydrate) (Standard) is the analytical standard of Pyridoxal 5'-phosphate (monohydrate). This product is intended for research and analytical applications. Pyridoxal 5'-phosphate monohydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate monohydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .

HY-W003445R

4-Bromo-3-hydroxybenzoic acid (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
4-Bromo-3-hydroxybenzoic acid (Standard) is the analytical standard of 4-Bromo-3-hydroxybenzoic acid (HY-W003445). This product is intended for research and analytical applications. 4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC50s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC50s of 1 mM for both enzymes .

HY-23964

4-Methylthio-2-oxobutanoic acid MTOB	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Ornithine decarboxylase (ODC)
4-Methylthio-2-oxobutanoic acid (MTOB) is an ornithine decarboxylase inhibitor. 4-Methylthio-2-oxobutanoic acid reduces ornithine decarboxylase protein levels and enzymatic activity. 4-Methylthio-2-oxobutanoic acid is formed in cells in the Met salvage pathway from methylthioadenosine. 4-Methylthio-2-oxobutanoic acid inhibits cancer cells growth. 4-Methylthio-2-oxobutanoic acid can be used for the research of cancer .

HY-B1713

Ornithine (±)-Ornithine	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite Ornithine decarboxylase (ODC) Drug Intermediate
Ornithine ((±)-Ornithine) is a non-essential amino acid. Ornithine is an intermediate in urea cycle and acts as a substrate for these rate limiting enzymes ornithine transcarbomylase, ornithine aminotransferase and ornithine decarboxylase producing citrulline, proline and polyamines, respectively. Ornithine can be used in the research of hyperornithinemia, hyperammonemia, and cancer .

HY-180668

*2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline*	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline is a product of the hydrolysis of 5-hydroxyisourate. 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline undergoes stereoselective decarboxylation by the action of 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase to give CO₂ and (S)-allantoin .

HY-W011727R

Pyridoxal 5'-phosphate hydrate (Standard) Pyridoxal phosphate hydrate (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards Amyloid-β ERK
Pyridoxal 5'-phosphate (hydrate) (Standard) is the analytical standard of Pyridoxal 5'-phosphate (hydrate) (HY-W011727). This product is intended for research and analytical applications. Pyridoxal 5'-phosphate hydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate hydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .

Species:	Human (20) Mouse (5) Cynomolgus (1) E.coli (2)
Tag:	T7 (1) SUMO (2) His (27) Tag Free (6) Strep (2) Myc (1) GST (2) Flag (3)
Source:	HEK293 (2) sf9 insect cells (1) Sf9 insect cells (5) E. coli (27)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703482

	rLuc Protein, Human (His, Strep) Coelenterazine h 2-monooxygenase; Renilla-luciferin 2-monooxygenase; Renilla-type luciferase; Renilla reniformis; Sea pansy; decarboxylase; Lyase; Monooxygenase; Oxidoreductase; Photoprotein; 1.13.12.5	Human	E. coli
	rLuc Protein, Human (His, Strep) is the recombinant human-derived rLuc, expressed by E. coli , with Strep, His labeled tag. ,

HY-P72151

	CSAD Protein, Mouse (His-SUMO) CsadCysteine sulfinic acid decarboxylase; EC 4.1.1.29; Aspartate 1-decarboxylase; EC 4.1.1.11; Cysteine-sulfinate decarboxylase; Sulfinoalanine decarboxylase	Mouse	E. coli
	CSAD proteins play a crucial role in the metabolism of sulfur-containing amino acids, catalyzing L-aspartate, 3-sulfinyl-L-alanine (cysteine sulfenic acid) and L-cysteine The acid is decarboxylated to produce β-alanine, hypotaurine and taurine respectively. Among these substrates, 3-sulfinyl-L-alanine is the preferred substrate for CSAD. CSAD Protein, Mouse (His-SUMO) is the recombinant mouse-derived CSAD protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P701909

	DDC Protein, Human DDC; Aromatic-L-amino-acid decarboxylase; AADC; DOPA decarboxylase; DDC	Human	E. coli
	DDC protein plays a central role in neurotransmitter synthesis by catalyzing the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to produce dopamine and L-5-hydroxytryptophan to produce serotonin. DDC Protein, Human is the recombinant human-derived DDC protein, expressed by E. coli , with tag free.

HY-P701949

	panD Protein, Corynebacterium jeikeium panD; Aspartate 1-decarboxylase; Aspartate alpha-decarboxylase	Others	E. coli
	The panD protein plays a crucial role in cellular metabolism by catalyzing the pyruvyl-dependent decarboxylation of aspartate, thereby producing β-alanine. This enzyme activity represents a key step in the biosynthesis of pantothenic acid (vitamin B5), since beta-alanine is the precursor for the formation of this important cofactor. panD Protein, Corynebacterium jeikeium is the recombinant panD protein, expressed by E. coli , with tag free.

HY-P74204

	DDC Protein, Mouse (sf9, His) Aromatic-L-amino-acid decarboxylase; AADC; DOPA decarboxylase; DDC	Mouse	Sf9 insect cells
	The DDC protein plays a key role in neurotransmitter synthesis as it catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to produce dopamine and L-5-hydroxytryptophan to produce serotonin. These enzymatic reactions represent key steps in neurotransmitter biosynthesis and are essential for the normal functioning of the central nervous system. DDC Protein, Mouse (sf9, His) is the recombinant mouse-derived DDC protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P701950

	panD Protein, Corynebacterium jeikeium (FLAG, His) panD; Aspartate 1-decarboxylase; Aspartate alpha-decarboxylase	Others	E. coli
	The panD protein plays a crucial role in cellular metabolism by catalyzing the pyruvyl-dependent decarboxylation of aspartate, thereby producing β-alanine. This enzyme activity represents a key step in the biosynthesis of pantothenic acid (vitamin B5), since beta-alanine is the precursor for the formation of this important cofactor. panD Protein, Corynebacterium jeikeium (FLAG, His) is the recombinant panD protein, expressed by E. coli , with N-6*His, N-Flag labeled tag.

HY-P701910

	DDC Protein, Human (His, Strep II) DDC; Aromatic-L-amino-acid decarboxylase; AADC; DOPA decarboxylase; DDC	Human	E. coli
	DDC protein plays a central role in neurotransmitter synthesis by catalyzing the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to produce dopamine and L-5-hydroxytryptophan to produce serotonin. DDC Protein, Human (His, Strep II) is the recombinant human-derived DDC protein, expressed by E. coli , with N-Strep II, N-6*His labeled tag.

HY-P704655

	DDC Protein, Human (Sf9, His) DDC; Aromatic-L-amino-acid decarboxylase; AADC; DOPA decarboxylase; DDC	Human	sf9 insect cells
	DDC protein plays a central role in neurotransmitter synthesis by catalyzing the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to produce dopamine and L-5-hydroxytryptophan to produce serotonin. DDC Protein, Human (Sf9, His) is the recombinant human-derived DDC protein, expressed by sf9 insect cells, with C-His labeled tag.

HY-P75178

	GAD2/GAD65 Protein, Mouse (sf9) 1 Publications Verification Glutamate decarboxylase 2; GAD-65; GAD2	Mouse	Sf9 insect cells
	GAD2/GAD65 Protein is a key enzyme in neurotransmitter metabolism, specifically catalyzing the production of gamma-aminobutyric acid (GABA). Meanwhile, GAD2 also has glutamate binding activity, glutamate decarboxylase activity, and pyridoxal phosphate binding activity. GAD2 is expressed in several structures, including the genitourinary system, the gastrointestinal nervous system, and sensory organs. It can be used to study epilepsy and type 1 diabetes. GAD2/GAD65 Protein, Mouse (sf9) is the recombinant mouse-derived GAD2/GAD65 protein, expressed by Sf9 insect cells, with tag free.

HY-P75179

	GAD2/GAD65 Protein, Human (sf9, GST) Glutamate decarboxylase 2; GAD-65; GAD2	Human	Sf9 insect cells
	GAD2/GAD65 proteins are key enzymes in neurotransmitter metabolism, specifically catalyzing the production of gamma-aminobutyric acid (GABA). GABA is an important inhibitory neurotransmitter in the central nervous system, playing a key role in regulating neuronal excitability and maintaining the balance between excitation and inhibition in the brain. GAD2/GAD65 Protein, Human (sf9, GST) is the recombinant human-derived GAD2/GAD65 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P75177

	GAD2/GAD65 Protein, Mouse (sf9, His-GST) Glutamate decarboxylase 2; GAD-65; GAD2	Mouse	Sf9 insect cells
	GAD2/GAD65 Protein is a key enzyme in neurotransmitter metabolism, specifically catalyzing the production of gamma-aminobutyric acid (GABA). Meanwhile, GAD2 also has glutamate binding activity, glutamate decarboxylase activity, and pyridoxal phosphate binding activity. GAD2 is expressed in several structures, including the genitourinary system, the gastrointestinal nervous system, and sensory organs. It can be used to study epilepsy and type 1 diabetes. GAD2/GAD65 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived GAD2/GAD65 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P75180

	GAD1/GAD67 Protein, Human (sf9, His) Glutamate decarboxylase 1; GAD-67; GAD1; GAD	Human	Sf9 insect cells
	The GAD1/GAD67 protein utilizes pyridoxal 5'-phosphate as a cofactor and acts as a catalyst in the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). GAD1 plays a key role in the conversion of glutamate to GABA, a key neurotransmitter involved in regulating neuronal excitability. GAD1/GAD67 Protein, Human (sf9, His) is the recombinant human-derived GAD1/GAD67 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P702097

	tdc Protein, Levilactobacillus brevis tdc; L-tyrosine decarboxylase; TDC	Others	E. coli
	TDC protein plays a key role in amino acid metabolism by catalyzing the decarboxylation of L-tyrosine to produce tyramine. TDC is specific and does not utilize other aromatic L-amino acids such as L-phenylalanine, L-tryptophan, and L-glutamate as substrates. tdc Protein, Levilactobacillus brevis is the recombinant tdc protein, expressed by E. coli , with tag free.

HY-P702092

	speA Protein, Shewanella putrefaciens speA; Biosynthetic arginine decarboxylase; ADC	Others	E. coli
	The speA protein plays a crucial role in catalyzing the transformation from arginine to agmatine. This enzymatic conversion highlights speA's significance in sustaining cellular metabolism and essential biological processes. By synthesizing agmatine, speA emerges as a key player in the intricate dance of molecular transformations that characterize fundamental cellular functions. speA Protein, Shewanella putrefaciens is the recombinant speA protein, expressed by E. coli , with tag free.

HY-P71080

	UROD Protein, Human (His) Uroporphyrinogen decarboxylase; UPD; URO-D; UROD	Human	E. coli
	UROD proteins catalyze the sequential decarboxylation of the acetate side chain of uroporphyrinogen to form coproporphyrinogen and contribute to the fifth step of the heme biosynthetic pathway. UROD Protein, Human (His) is the recombinant human-derived UROD protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71109

	ODC1 Protein, Human (His-T7) 1 Publications Verification Ornithine decarboxylase; ODC1;	Human	E. coli
	ODC (ornithine decarboxylase) is the rate-limiting enzyme in polyamine biosynthesis, catalyzing the conversion of ornithine to putrescine, a precursor of polyamines such as spermidine and spermine, which influence cell proliferation and various cellular processes. ODC1 Protein, Human (His-T7) is the recombinant human-derived ODC1 protein, expressed by E. coli , with N-T7, C-6*His labeled tag.

HY-P71222

	PPC-DC Protein, Human (His) Phosphopantothenoylcysteine decarboxylase; PPC-DC; PPCDC; COAC	Human	E. coli
	PPC-DC proteins are central players in cellular ubiquitination, covalently linking ubiquitin to target proteins. Its critical role extends to the selective degradation of misfolded membrane proteins, an important process in endoplasmic reticulum-associated degradation (ERAD). PPC-DC Protein, Human (His) is the recombinant human-derived PPC-DC protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702091

	speA Protein, Shewanella putrefaciens (FLAG, His) speA; Biosynthetic arginine decarboxylase; ADC	Others	E. coli
	The speA protein plays a crucial role in catalyzing the transformation from arginine to agmatine. This enzymatic conversion highlights speA's significance in sustaining cellular metabolism and essential biological processes. By synthesizing agmatine, speA emerges as a key player in the intricate dance of molecular transformations that characterize fundamental cellular functions. speA Protein, Shewanella putrefaciens (FLAG, His) is the recombinant speA protein, expressed by E. coli , with N-6*His, N-Flag labeled tag.

HY-P702096

	tdc Protein, Levilactobacillus brevis (FLAG, His) tdc; L-tyrosine decarboxylase; TDC	Others	E. coli
	TDC protein plays a key role in amino acid metabolism by catalyzing the decarboxylation of L-tyrosine to produce tyramine. TDC is specific and does not utilize other aromatic L-amino acids such as L-phenylalanine, L-tryptophan, and L-glutamate as substrates. tdc Protein, Levilactobacillus brevis (FLAG, His) is the recombinant tdc protein, expressed by E. coli , with N-6*His, N-Flag labeled tag.

HY-P702593

	ODC1 Protein, Human (His-SUMO, Myc) Ornithine decarboxylase; ODC1;	Human	E. coli
	ODC (ornithine decarboxylase) is the rate-limiting enzyme in polyamine biosynthesis, catalyzing the conversion of ornithine to putrescine, a precursor of polyamines such as spermidine and spermine, which influence cell proliferation and various cellular processes. ODC1 Protein, Human (His-SUMO, Myc) is the recombinant human-derived ODC1, expressed by E. coli, with N-10*His, C-Myc, N-SUMO labeled tag.

HY-P703833

	DDT Protein, Mouse (His) D-dopachrome decarboxylase; D-dopachrome tautomerase; Ddt;	Mouse	E. coli
	DDT Protein, Mouse (His) is the recombinant mouse-derived DDT protein, expressed by E. coli, with N-His tag.

HY-P71222A

	PPC-DC Protein, Human (His, solution) Phosphopantothenoylcysteine decarboxylase; PPC-DC; PPCDC; COAC	Human	E. coli
	PPC-DC proteins are central players in cellular ubiquitination, covalently linking ubiquitin to target proteins. Its critical role extends to the selective degradation of misfolded membrane proteins, an important process in endoplasmic reticulum-associated degradation (ERAD). PPC-DC Protein, Human (His, solution) is the recombinant human-derived PPC-DC protein, expressed by E. coli , with N-6*His labeled tag.

HY-P703512

	*Lysine decarboxylase* Protein, Klebsiella pneumoniae IS43 (His)** Klebsiella pneumoniae IS43; Lyase	Others	E. coli
	Lysine decarboxylase Protein, Klebsiella pneumoniae IS43 (His) is the recombinant Lysine decarboxylase, expressed by E. coli , with His labeled tag. ,

HY-P703834

	DDT Protein, Human (His) D-dopachrome decarboxylase; D-dopachrome tautomerase; Phenylpyruvate tautomerase II; DDT;	Human	E. coli
	DDT Protein, Human (His) is the recombinant human-derived DDT protein, expressed by E. coli, with N-His tag.

HY-P700387

	LDCC Protein, E.coli (His) ECK0185; JW0181; ldc; LDC2; ldcH; lysine decarboxylase 2, constitutive	E.coli	E. coli
	LDCC protein is also called lysine decarboxylase. As an enzyme that can catalyze the decarboxylation of lysine, it plays a key role in the utilization of lysine. This enzymatic activity enables LDCC to remove carboxyl groups from lysine, thereby generating cadaverine, a biogenic amine. LDCC Protein, E.coli (His) is the recombinant E. coli-derived LDCC protein, expressed by E. coli , with C-6*His labeled tag.

HY-P71695

	SPEA Protein, E.coli (His) speA; b2938; JW2905; Biosynthetic arginine decarboxylase; ADC; EC 4.1.1.19	E.coli	E. coli
	SPEA is a key enzyme in cellular metabolism responsible for the biosynthesis of agmatine from arginine. This catalytic process involves the conversion of arginine to agmatine, thereby forming a complex network of biochemical pathways within the cell. SPEA Protein, E.coli (His) is the recombinant E. coli-derived SPEA protein, expressed by E. coli , with N-His labeled tag.

HY-P70294

	Glutamine synthetase/GLUL Protein, Human (His) rHuGlutamine synthetase/GLUL, His; Glutamine Synthetase; GS; Glutamate decarboxylase; Glutamate--Ammonia Ligase; GLUL; GLNS	Human	E. coli
	GLUL proteins catalyze the conversion of glutamate and ammonia to glutamine. Glutamine synthetase/GLUL Protein, Human (His) is the recombinant human-derived Glutamine synthetase/GLUL protein, expressed by E. coli , with C-6*His labeled tag.

HY-P703783

	DDT Protein, Cynomolgus (His) D-DT; D-dopachrome decarboxylase; D-dopachrome tautomerase; Phenylpyruvate tautomerase II; EC 4.1.1.84; MIF2; DDCT	Cynomolgus	E. coli
	DDT Protein, Cynomolgus (His) is the recombinant cynomolgus-derived DDT protein, expressed by E. coli, with N-His tag.

HY-P701981

	MCD Protein, Human (E58A, K59A, E278A, E279A, K280A) MLYCD; Malonyl-CoA decarboxylase; mitochondrial; MCD	Human	E. coli
	MCD proteins catalyze the conversion of malonyl-CoA to acetyl-CoA, ensuring that only methylmalonyl-CoA serves as a substrate for fatty acid synthase, producing fatty acids with multiple methyl side chains. MCD Protein, Human (E58A, K59A, E278A, E279A, K280A) is the recombinant human-derived MCD protein, expressed by E. coli , with tag free.

HY-P701982

	MCD Protein, Human (E58A, K59A, E278A, E279A, K280A, His) MLYCD; Malonyl-CoA decarboxylase; mitochondrial; MCD	Human	E. coli
	MCD proteins catalyze the conversion of malonyl-CoA to acetyl-CoA, ensuring that only methylmalonyl-CoA serves as a substrate for fatty acid synthase, producing fatty acids with multiple methyl side chains. MCD Protein, Human (E58A, K59A, E278A, E279A, K280A, His) is the recombinant human-derived MCD protein, expressed by E. coli , with N-6*His labeled tag.

HY-P704086

	IDH1 Protein, Human (His) rHuIsocitrate dehydrogenase [NADP] cytoplasmic/IDH1, His; Isocitrate Dehydrogenase [NADP] Cytoplasmic; IDH; Cytosolic NADP-Isocitrate Dehydrogenase; IDP; NADP(+)-Specific ICDH; Oxalosuccinate decarboxylase; IDH1; PICD	Human	E. coli
	The IDH1 protein catalyzes the oxidative decarboxylation of isocitrate to generate 2-oxoglutarate, which is utilized by enzymes such as phytoacyl-CoA dioxygenase. IDH1 Protein, Human (His) is the recombinant human-derived IDH1 protein, expressed by E. coli, with C-8*His labeled tag.

HY-P70214A

	IDH1 Protein, Human (HEK293, His) rHuIsocitrate dehydrogenase [NADP] cytoplasmic/IDH1, His; Isocitrate Dehydrogenase [NADP] Cytoplasmic; IDH; Cytosolic NADP-Isocitrate Dehydrogenase; IDP; NADP(+)-Specific ICDH; Oxalosuccinate decarboxylase; IDH1; PICD	Human	HEK293
	The IDH1 protein catalyzes the oxidative decarboxylation of isocitrate to generate 2-oxoglutarate, which is utilized by enzymes such as phytoacyl-CoA dioxygenase. IDH1 Protein, Human (HEK293, His) is the recombinant human-derived IDH1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70214

	IDH1 Protein, Human (HEK293, His, Solution) rHuIsocitrate dehydrogenase [NADP] cytoplasmic/IDH1, His; Isocitrate Dehydrogenase [NADP] Cytoplasmic; IDH; Cytosolic NADP-Isocitrate Dehydrogenase; IDP; NADP(+)-Specific ICDH; Oxalosuccinate decarboxylase; IDH1; PICD	Human	HEK293
	The IDH1 protein catalyzes the oxidative decarboxylation of isocitrate to generate 2-oxoglutarate, which is utilized by enzymes such as phytoacyl-CoA dioxygenase. IDH1 Protein, Human (HEK293, His, Solution) is the recombinant human-derived IDH1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P704085

	IDH1 Protein, Human (R132H, His) rHuIsocitrate dehydrogenase NADP cytoplasmic/IDH1, His; Isocitrate Dehydrogenase NADP Cytoplasmic; IDH; Cytosolic NADP-Isocitrate Dehydrogenase; IDP; NADP(+)-Specific ICDH; Oxalosuccinate decarboxylase; IDH1; PICD	Human	E. coli
	The IDH1 protein catalyzes the oxidative decarboxylation of isocitrate to generate 2-oxoglutarate, which is utilized by enzymes such as phytoacyl-CoA dioxygenase. IDH1 Protein, Human (R132H, His) is the recombinant human-derived IDH1 protein, expressed by E. coli, with C-8*His labeled tag.

HY-P704669

	IDH1 Protein, Human (R132C, His) rHuIsocitrate dehydrogenase NADP cytoplasmic/IDH1, His; Isocitrate Dehydrogenase NADP Cytoplasmic; IDH; Cytosolic NADP-Isocitrate Dehydrogenase; IDP; NADP(+)-Specific ICDH; Oxalosuccinate decarboxylase; IDH1; PICD	Human	E. coli
	The IDH1 protein catalyzes the oxidative decarboxylation of isocitrate to generate 2-oxoglutarate, which is utilized by enzymes such as phytoacyl-CoA dioxygenase. IDH1 Protein, Human (R132C, His) is the recombinant human-derived IDH1 protein, expressed by E. coli, with C-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W011727S

Pyridoxal Phosphate-d3

Pyridoxal Phosphate-d₃ is the deuterium labeled Pyridoxal 5'-phosphate. Pyridoxal 5'-phosphate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .

HY-114118S1

Semaglutide-d8 tetraTFA

Semaglutide-d₈ tetraTFA is the deuterium labeled Semaglutide (HY-114118). Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .

HY-114118S

Semaglutide-d8

Semaglutide-d₈ is the deuterium labeled Semaglutide (HY-114118). Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .

HY-N0384S2

Homovanillic acid-d5
Homovanillic acid-d₅ (Vanilacetic acid-d₅) is the deuterium labeled Homovanillic acid (HY-N0384). Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency .

HY-Y0367S

Maleic acid-d2
Maleic Acid-d₂ is the deuterium labeled Maleic Acid . Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes .

HY-B0311AS

Carbidopa-d3 monohydrate
Carbidopa-d₃ (monohydrate) is the deuterium labeled Carbidopa monohydrate. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth .

HY-N0384S

Homovanillic acid-d3
Homovanillic acid-d₃ (Vanilacetic acid-d₃) is the deuterium labeled Homovanillic acid (HY-N0384). Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency .

HY-B0404AS

Benserazide-d3 hydrochloride

Benserazide-d₃ (hydrochloride) is the deuterium labeled Benserazide hydrochloride (HY-B0404A). Benserazide hydrochloride (Serazide) is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. Benserazide hydrochloride is also a PKM2 inhibitor. Benserazide hydrochloride directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide hydrochloride can be used for the study of Parkinson's disease and melanoma .

HY-N0384S1

Homovanillic acid-d2
Homovanillic acid-d₂ (Vanilacetic acid-d₂) is the deuterium labeled Homovanillic acid (HY-N0384). Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency .

HY-W015300S

Suberic acid-d4
Suberic acid-d₄ is the deuterium labeled Suberic acid . Suberic acid (Octanedioic acid) is found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency .

HY-W015300S1

Suberic acid-d12
Suberic acid-d₁₂ is the deuterium labeled Suberic acid . Suberic acid (Octanedioic acid) is found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency .

HY-W777477

Homovanillic Acid-13C6
Homovanillic Acid- ¹³C₆ (Vanilacetic acid- ¹³C₆) is the ¹³C-labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-B0311S1

Carbidopa-d3-1
Carbidopa-d3-1 is the deuterium labeled Carbidopa (HY-B0311). Carbidopa, a peripheral *decarboxylase* inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .

HY-N0384S4

Homovanillic acid-d3-1
Homovanillic acid-d₃-1 (Vanilacetic acid-d₃-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency .

HY-N0384S3

Homovanillic acid-13C6,18O
Homovanillic acid- ¹³C₆, ¹⁸O (Vanilacetic acid- ¹³C₆, ¹⁸O) is the ¹³C- and ¹⁸O-labeled Homovanillic acid (HY-N0384). Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency .

HY-N0384S5

Homovanillic acid-13C,d3
Homovanillic acid- ¹³C,d₃ (Vanilacetic acid- ¹³C,d₃) is ¹³C and deuterium labeled Homovanillic acid (HY-N0384). Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency .

Host:	Mouse (3) Rabbit (8)
Reactivity:	Human (8) mouse (1) rat (1) Rat (5) Mouse (8) human (1)
Application:	IHC-P (3) ICC/IF (5) IF-Tissue (2) IP (4) IHC-F (1) WB (11) ELISA (3)
Isotype:	IgG (7) IgG1 (2) IgG/Kappa (1)
Conjugation:	Non-conjugated (11)
Clonality:	Polyclonal (1) Monoclonal (7) Recombinant (5)
Modification:	Unmodified (9)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82683

	*DOPA Decarboxylase* Antibody (YA2428)** AADC; Aromatic L Amino Acid decarboxylase; DDC; DOPA decarboxylase (aromatic L-amino acid decarboxylase); DOPA decarboxylase	WB	Human, Mouse, Rat
	DOPA Decarboxylase Antibody (YA2428) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DOPA Decarboxylase.

HY-P82062

	GAD67 Antibody (YA1807) Glutamate decarboxylase 1; 67 kDa glutamic acid decarboxylase; GAD 67; GAD1; GAD; GAD67	WB, IP	Human
	GAD67 Antibody (YA1807) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GAD67.

HY-P82062A

	GAD67 Antibody (YA1807)(PBS only) Glutamate decarboxylase 1; 67 kDa glutamic acid decarboxylase; GAD 67; GAD1; GAD; GAD67	WB, IP	Human
	GAD67 Antibody (YA1807) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GAD67.

HY-P86884

	GAD67 Antibody (YA6577) 67 kDa glutamic acid decarboxylase antibody; CPSQ1 antibody; DCE1 antibody; DCE1_HUMAN antibody; EC 4.1.1.15 antibody; FLJ45882 antibody; GAD 67 antibody; GAD antibody; GAD-67 antibody; GAD1 antibody; 67 kDa glutamic acid decarboxylase antibody; CPSQ1 antibody; DCE1 antibody; DCE1_HUMAN antibody; EC 4.1.1.15 antibody; FLJ45882 antibody; GAD 67 antibody; GAD antibody; GAD-67 antibody; GAD1 antibody; Glutamate decarboxylase 1 (brain, 67kDa) antibody; Glutamate decarboxylase 1 antibody; Glutamate decarboxylase 1 brain 67kD antibody; Glutamate decarboxylase 1 brain 67kDa antibody; Glutamate decarboxylase 67 kDa isoform antibody; Glutamate decarboxylase, brain, 67-KD antibody; OTTHUMP00000041055 antibody; SCP antibody;	WB, IHC-P, IHC-F, IF-Tissue	Mouse, Rat
	GAD67 Antibody (YA6577) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GAD67.

HY-P810398

	IRG1 Antibody (YA9713) ACOD1, Aconitate decarboxylase 1, Aconitate decarboxylase, CAD, Cis aconitate decarboxylase, Immune responsive gene 1 protein homolog, Immune-responsive gene 1 protein homolog, Immunoresponsive 1 homolog (mouse), Irg1, IRG1_HUMAN	WB, ICC/IF	Human, Mouse
	IRG1 Antibody (YA9713) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to IRG1.

HY-P84947

	IRG1 Antibody ACOD1 antibody; Aconitate decarboxylase 1 antibody; Aconitate decarboxylase antibody; CAD antibody; Cis aconitate decarboxylase antibody; Immune responsive gene 1 protein homolog antibody; Immune-responsive gene 1 protein homolog antibody; Immunoresponsive 1 homolog (mouse) antibody; Irg1 antibody; IRG1_HUMAN antibody; OC116 antibody ; OPTB1 antibody; TCTIRC7 antibody	WB	Human, Mouse
	IRG1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IRG1.

HY-P84946

	IRG1 Antibody (YA4642) ACOD1 antibody; Aconitate decarboxylase 1 antibody; Aconitate decarboxylase antibody; CAD antibody; Cis aconitate decarboxylase antibody; Immune responsive gene 1 protein homolog antibody; Immune-responsive gene 1 protein homolog antibody; Immunoresponsive 1 homolog (mouse) antibody; Irg1 antibody; IRG1_HUMAN antibody; OC116 antibody ; OPTB1 antibody; TCTIRC7 antibody	WB, ICC/IF	Mouse
	IRG1 Antibody (YA4642) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRG1.

HY-P85817

	Glutamine synthetase Antibody (YA5509) GLUL; GLNS; Glutamine synthetase; GS; Glutamate decarboxylase; Glutamate--ammonia ligase	WB, ICC/IF, ELISA, IHC-P	Human, Mouse, Rat
	Glutamine synthetase Antibody (YA5509) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Glutamine synthetase.

HY-P86524

	Glutamine Synthetase Antibody (YA6216) GLUL; GLNS; Glutamine synthetase; GS; Glutamate decarboxylase; Glutamate--ammonia ligase	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Glutamine Synthetase Antibody (YA6216) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glutamine Synthetase.

HY-P810301

	PDXDC1 Antibody LP8165; PDXD1; pyridoxal-dependent decarboxylase domain containing 1	WB	Human, Mouse, Rat
	PDXDC1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PDXDC1.

HY-P89593

	GLDC Antibody (YA8937) GCSP, GLDC, Glycine cleavage system P protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat
	GLDC Antibody (YA8937) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GLDC.