4-(Dimethylamino)cinnamaldehyde
Based on 1 publication(s) in Google Scholar
4-(Dimethylamino) cinnamaldehyde is a staining agent that reacts with flavan-3-ols and Proanthocyanidins (HY-N0794) bearing meta-dihydroxyl or trihydroxyl phenol structures to form a green chromophore. In acidic media, 4-(Dimethylamino) cinnamaldehyde undergoes a condensation reaction with aromatic primary amines to produce colored and stable quinoid protonated Schiff base salts. 4-(Dimethylamino) cinnamaldehyde can be used to determine indole products of apotryptophanase and tryptophanase, as well as for the detection and analysis of Proanthocyanidins, with the absorbance detection wavelength of the calibration curve set at 640 nm.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 6203-18-5
- Formula: C11H13NO
- Molecular Weight:175.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 4-(Dimethylamino)cinnamaldehyde
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Biological Activity
4-(Dimethylamino) cinnamaldehyde forms stable colored protonated quinoidal Schiff bases with aniline, most substituted anilines and aniline drugs in acidic citrate buffer media, and its protonation pK value is 3.18, which enables the determination of these amines by spectrophotometry[1].
4-(Dimethylamino) cinnamaldehyde (DMAC) can determine the content of Proanthocyanidins (HY-N0794) in cranberry powders (A, B, C) and cranberry juices (A, B, C, D)[2].
4-(Dimethylamino) cinnamaldehyde reacts with purified (-)-Epicatechin (HY-N0001), Procyanidin A2 (HY-N2343), and isolated cranberry Proanthocyanidins to form two stable cationic products (pyranium-type and ring-opened type)[3].
4-(Dimethylamino) cinnamaldehyde reacts with Catechin (HY-N0898), Procyanidin A2, Procyanidin B2 (HY-N0796) and cranberry Proanthocyanidins to produce colorimetric products, which exhibit distinct maximum absorbance values, Tmax times and calibration curve slopes[3].
4-(Dimethylamino) cinnamaldehyde assay enables the quantification of non-extractable Proanthocyanidins (NEPA) in the seed coat of red wheat. Studies show that NEPA content increases during seed maturation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6203-18-5
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Appearance Solid
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Molecular Weight 175.23
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Formula C11H13NO
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Color Yellow to orange
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SMILES
O=C/C=C/C1=CC=C(N(C)C)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Clin Exp Hypertens
Cinnamaldehyde alleviates pulmonary hypertension by affecting vascular remodeling through the TLR4/NF-kB/HIF-1a pathway. [Abstract]2025 Dec;47(1):2486829. PMID: 40171680
Solvent & Solubility
DMSO : 100 mg/mL (570.68 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
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Handling Instructions (2659 KB)
References
[2]. Feliciano RP, et al. Comparison of isolated cranberry (Vaccinium macrocarpon Ait.) proanthocyanidins to catechin and procyanidins A2 and B2 for use as standards in the 4-(dimethylamino)cinnamaldehyde assay. Journal of agricultural and food chemistry. 2012 May 09;60(18):4578-85. [Content Brief]
[3]. Dini I. Recent Advances in Natural Polyphenol Research. Molecules, 2022, 27(24): 8777.
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.7068 mL | 28.5339 mL | 57.0679 mL | 142.6696 mL |
| 5 mM | 1.1414 mL | 5.7068 mL | 11.4136 mL | 28.5339 mL | |
| 10 mM | 0.5707 mL | 2.8534 mL | 5.7068 mL | 14.2670 mL | |
| 15 mM | 0.3805 mL | 1.9023 mL | 3.8045 mL | 9.5113 mL | |
| 20 mM | 0.2853 mL | 1.4267 mL | 2.8534 mL | 7.1335 mL | |
| 25 mM | 0.2283 mL | 1.1414 mL | 2.2827 mL | 5.7068 mL | |
| 30 mM | 0.1902 mL | 0.9511 mL | 1.9023 mL | 4.7557 mL | |
| 40 mM | 0.1427 mL | 0.7133 mL | 1.4267 mL | 3.5667 mL | |
| 50 mM | 0.1141 mL | 0.5707 mL | 1.1414 mL | 2.8534 mL | |
| 60 mM | 0.0951 mL | 0.4756 mL | 0.9511 mL | 2.3778 mL | |
| 80 mM | 0.0713 mL | 0.3567 mL | 0.7133 mL | 1.7834 mL | |
| 100 mM | 0.0571 mL | 0.2853 mL | 0.5707 mL | 1.4267 mL |
4-(Dimethylamino)cinnamaldehyde Related Classifications
HY-W016729 Related Classifications
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