Foscarbidopa
Based on 1 Customer Validation
Foscarbidopa (ABBV-951; Carbidopa 4′-monophosphate) is an inhibitory prodrug targeting peripheral aromatic L-amino acid decarboxylase. Foscarbidopa is hydrolyzed into Carbidopa (HY-B0311) by phosphatases in vivo to suppress peripheral metabolism of levodopa and elevate brain delivery of levodopa. Foscarbidopa can be used for the research of Parkinson’s disease and advanced Parkinson’s disease.
For research use only. We do not sell to patients.
- Purity: 95.91%
- CAS No.: 1907685-81-7
- Formula: C10H15N2O7P
- Molecular Weight:306.21
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Biological Activity
dopamine receptor[2]
Foscarbidopa (combined with foslevodopa; intravenous/subcutaneous bolus/infusion) shows favorable pharmacokinetic profiles in rats, dogs, Göttingen minipigs and monkeys[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1907685-81-7
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Appearance Solid
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Molecular Weight 306.21
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Formula C10H15N2O7P
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Color White to off-white
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SMILES
O=P(O)(O)OC(C=CC(C[C@@](NN)(C)C(O)=O)=C1)=C1O
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Synonyms
ABBV-951; Carbidopa 4′-monophosphate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 10 mg/mL (32.66 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.2657 mL | 16.3287 mL | 32.6573 mL | 81.6433 mL |
| 5 mM | 0.6531 mL | 3.2657 mL | 6.5315 mL | 16.3287 mL | |
| 10 mM | 0.3266 mL | 1.6329 mL | 3.2657 mL | 8.1643 mL | |
| 15 mM | 0.2177 mL | 1.0886 mL | 2.1772 mL | 5.4429 mL | |
| 20 mM | 0.1633 mL | 0.8164 mL | 1.6329 mL | 4.0822 mL | |
| 25 mM | 0.1306 mL | 0.6531 mL | 1.3063 mL | 3.2657 mL | |
| 30 mM | 0.1089 mL | 0.5443 mL | 1.0886 mL | 2.7214 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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