MCD Protein, Human (E58A, K59A, E278A, E279A, K280A)
MCD proteins catalyze the conversion of malonyl-CoA to acetyl-CoA, ensuring that only methylmalonyl-CoA serves as a substrate for fatty acid synthase, producing fatty acids with multiple methyl side chains. MCD Protein, Human (E58A, K59A, E278A, E279A, K280A) is the recombinant human-derived MCD protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
MCD proteins catalyze the conversion of malonyl-CoA to acetyl-CoA, ensuring that only methylmalonyl-CoA serves as a substrate for fatty acid synthase, producing fatty acids with multiple methyl side chains. MCD Protein, Human (E58A, K59A, E278A, E279A, K280A) is the recombinant human-derived MCD protein, expressed by E. coli , with tag free.
The MCD protein plays a pivotal role in cellular metabolism by catalyzing the conversion of malonyl-CoA to acetyl-CoA. Particularly significant in fatty acid biosynthesis, MCD selectively eliminates malonyl-CoA, ensuring that methyl-malonyl-CoA becomes the exclusive substrate for fatty acid synthase. This selective removal mechanism contributes to the production of fatty acids with multiple methyl side chains. In peroxisomes, MCD is implicated in the degradation of intraperoxisomal malonyl-CoA, a byproduct of peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Beyond its involvement in lipid metabolism, MCD influences the metabolic balance between glucose and lipid oxidation in muscle, independent of insulin signaling alterations. Additionally, MCD may play a role in mitigating ischemic injury by promoting glucose oxidation, highlighting its multifaceted impact on cellular functions and metabolic pathways.
Technical Parameters
-
Species Human
-
Source E. coli
-
Tag Tag Free
-
Accession
O95822 (M40-S491, E58A, K59A, E278A, E279A, K280A)
-
Gene ID23417
-
Molecular Construction
-
N-term
-
MCD (M40-S491, E58A, K59A, E278A, E279A, K280A)
Accession # O95822 -
C-term
-
-
Protein Length
Full Length of MLYCD
-
Synonyms
MLYCD; Malonyl-CoA decarboxylase; mitochondrial; MCD
-
AA Sequence
MDELLRRAVPPTPAYELRAATPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETAAANKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNS
-
Predicted Molecular Mass
50.5 kDa
-
Purity
≥ 90%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
