2. Antibodies
  3. Primary Antibodies
  4. Polyclonal Antibodies
  5. IRG1 Antibody

IRG1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IRG1.

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20 μL Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Obtener un presupuesto  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Descripciòn

Descripciòn

IRG1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IRG1.
Host

Rabbit
Clonality

Polyclonal
Peso molecular
Predicted band size: 54 kDa;
Observed band size: 54 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse
SwissProt ID
Gene ID
Immunogen

Synthetic peptide of human ACOD1 aa386-422.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:2000
Pureza affinity purified Conjugation Non-conjugated
Modification Unmodified Isotype IgG
Appearance

Liquid
Formulation

Supplied in pH 7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Envío

Shipping with blue ice.
Background
Function：Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response (PubMed:23609450, PubMed:23610393, PubMed:30635240, PubMed:31548418). Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages (PubMed:23609450). Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB (PubMed:23610393, PubMed:35662396). Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (PubMed:30635240). Plays a role in the embryo implantation (PubMed:14500577)
Subcellular Localization：Mitochondrion
Expression：
Tissue_specificity:Expression in LPS-tolerant macrophages (protein level) (PubMed:23609450, PubMed:35662396) . Expression in pregnant uterine epithelial cells (PubMed:14500577) . Expression in microglia and macrophages (PubMed:23609450, PubMed:23610393, PubMed:35662396) .

Induction:Up-regulated after lipopolysaccharide (LPS) stimulation (PubMed:23609450, PubMed:23610393) . Up-regulated in LPS-tolerized macrophage by LPS (PubMed:23609450, PubMed:23610393) . Up-regulated synergistically by pro-inflammatory cytokines TNF and IFNG (PubMed:19014335) . Up-regulated by pro-inflammatory cytokines IL1B and IFNB1 (PubMed:19014335) . Up-regulated by progesterone and at the time of the embryo implantation (PubMed:14500577) . Expression is activated by IRF1 in neurons in response to flavivirus infection in neurons (PubMed:30635240)
Subunit：Homodimer
Database

Entrez Gene: 730249 Human ; 16365 Mouse

SwissProt: A6NK06 Human ; P54987 Mouse

OMIM: 615275 Human

Synonyms
ACOD1 antibody; Aconitate decarboxylase 1 antibody; Aconitate decarboxylase antibody; CAD antibody; Cis aconitate decarboxylase antibody; Immune responsive gene 1 protein homolog antibody; Immune-responsive gene 1 protein homolog antibody; Immunoresponsive 1 homolog (mouse) antibody; Irg1 antibody; IRG1_HUMAN antibody; OC116 antibody ; OPTB1 antibody; TCTIRC7 antibody
Documentación
User Guide for Antibodies (1077 KB)

IRG1 Antibody Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nombre del producto:
IRG1 Antibody
Cat. No.:
HY-P84947
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