IRG1 Antibody
(Synonyms: ACOD1 antibody; Aconitate decarboxylase 1 antibody; Aconitate decarboxylase antibody; CAD antibody; Cis aconitate decarboxylase antibody; Immune responsive gene 1 protein homolog antibody; Immune-responsive gene 1 protein homolog antibody; Immunoresponsive 1 homolog (mouse) antibody; Irg1 antibody; IRG1_HUMAN antibody; OC116 antibody ; OPTB1 antibody; TCTIRC7 antibody)IRG1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IRG1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse
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Formulation:
Supplied in pH 7.4 PBS, 0.05% NaN3, 40% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:2000 |
Product Details
IRG1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IRG1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 54 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 54 kDa
Synthetic peptide of human ACOD1 aa386-422.
affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in pH 7.4 PBS, 0.05% NaN3, 40% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IRG1 is a Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation[1][2][3][4][5][6].
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Subcellular Localization
Mitochondrion
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Expression
Tissue_specificity:Expression in LPS-tolerant macrophages (protein level) (PubMed:23609450, PubMed:35662396) . Expression in pregnant uterine epithelial cells (PubMed:14500577) . Expression in microglia and macrophages (PubMed:23609450, PubMed:23610393, PubMed:35662396) .
Induction:Up-regulated after lipopolysaccharide (LPS) stimulation (PubMed:23609450, PubMed:23610393) . Up-regulated in LPS-tolerized macrophage by LPS (PubMed:23609450, PubMed:23610393) . Up-regulated synergistically by pro-inflammatory cytokines TNF and IFNG (PubMed:19014335) . Up-regulated by pro-inflammatory cytokines IL1B and IFNB1 (PubMed:19014335) . Up-regulated by progesterone and at the time of the embryo implantation (PubMed:14500577) . Expression is activated by IRF1 in neurons in response to flavivirus infection in neurons (PubMed:30635240) -
Subunit
Homodimer
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SwissProt ID
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Synonyms
ACOD1 antibody; Aconitate decarboxylase 1 antibody; Aconitate decarboxylase antibody; CAD antibody; Cis aconitate decarboxylase antibody; Immune responsive gene 1 protein homolog antibody; Immune-responsive gene 1 protein homolog antibody; Immunoresponsive 1 homolog (mouse) antibody; Irg1 antibody; IRG1_HUMAN antibody; OC116 antibody ; OPTB1 antibody; TCTIRC7 antibody
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