ACOD1 - aconitate decarboxylase 1 Gene

Also Known as CAD; IRG1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 730249

About ACOD1

Cytogenetic location: 13q22.3 Genomic coordinates (GRCh38): 13:76,948,511-76,958,638 (from NCBI)

This gene has 2 transcripts (splice variants) and 188 orthologues. Low expression observed in reference dataset.

Summary

Enables aconitate decarboxylase activity. Involved in defense response; positive regulation of antimicrobial humoral response; and tolerance induction to lipopolysaccharide. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

ACOD1 Products (1)

mRNA Protein Name
NM_001258406.2 NP_001245335.1 cis-aconitate decarboxylase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables aconitate decarboxylase activity IDA
IDA: Inferred from direct assay
23610393 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
31548418 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
23609450 GOA
involved in defense response IDA
IDA: Inferred from direct assay
23610393 GOA
involved in positive regulation of antimicrobial humoral response IDA
IDA: Inferred from direct assay
23610393 GOA
involved in tolerance induction to lipopolysaccharide IDA
IDA: Inferred from direct assay
23609450 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACOD1 Protein Structure

MmgE_PrpD

MmgE_PrpD: MmgE/PrpD family (5 - 447)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 481 a.a.
Protein Preferred Names Protein Names

cis-aconitate decarboxylase

  • cis-aconitic acid decarboxylase

Related Diseases

Diseases Alias
Alzheimer Disease 5

  • Ad5

  • Alzheimer'S Disease 5

  • Alzheimer Disease, Familial, 5

  • Alzheimer Disease-5

  • Alzheimer Disease, Familial 5

  • Alzheimer'S Disease 5, Late Onset

  • Alzheimer Disease, Familial, Type 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16239 Acod1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00172 ACOD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24527 Acod1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ACOD1 VGNC VGNC:37515
Felis catus ACOD1 VGNC VGNC:59517
Mus musculus ACOD1 MGD MGI:103206
Rattus norvegicus ACOD1 RGD RGD:1563454
Macaca mulatta ACOD1 VGNC VGNC:106248
Bos taurus ACOD1 VGNC VGNC:58358
Others ACOD1 NCBI