2. Others Metabolic Enzyme/Protease
  3. Acetyl-CoA Carboxylase Environmental Pollutants Herbicide
  4. Fluazifop-P-butyl

Fluazifop-P-butyl is an orally active herbicide and ACCase inhibitor. Fluazifop-P-butyl blocks the formation of malonyl-CoA, disrupts lipid synthesis in sensitive plants, and exhibits concentration-dependent phytotoxicity to non-target maize seedlings. Fluazifop-P-butyl induces oxidative stress in male Wistar rats, impairs their liver and kidney functions, and disrupts testicular function.

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Fluazifop-P-butyl

Fluazifop-P-butyl Chemical Structure

CAS No. : 79241-46-6

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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50 mg In-stock
100 mg In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Fluazifop-P-butyl:

Fluazifop-P-butyl Related Antibodies

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Description

Fluazifop-P-butyl is an orally active herbicide and ACCase inhibitor. Fluazifop-P-butyl blocks the formation of malonyl-CoA, disrupts lipid synthesis in sensitive plants, and exhibits concentration-dependent phytotoxicity to non-target maize seedlings. Fluazifop-P-butyl induces oxidative stress in male Wistar rats, impairs their liver and kidney functions, and disrupts testicular function[1][2].

In Vitro

Fluazifop-P-butyl (0.65-65 μM; soaked for 1 min; grown for 7 days) inhibits shoot and root elongation of Zea mays var. saccharata L. cv. Złota Karłowa seedlings in a concentration-dependent manner, with roots showing higher sensitivity than shoots. It also regulates the levels of photosynthetic pigments in seedling leaves[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fluazifop-P-butyl Related Antibodies
In Vivo

Fluazifop-P-butyl (18.75-75.00 mg/kg; p.o.; daily; for consecutive 21 days) induces dose-dependent hepatotoxicity, nephrotoxicity, and oxidative stress-mediated testicular dysfunction in male Wistar rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar mice (male, 160-180 g)[2]
Dosage: 18.75 mg/kg; 37.50 mg/kg; 75.00 mg/kg
Administration: p.o.; daily; 21 days
Result: Increased plasma urea levels significantly.
Increased plasma creatinine levels significantly.
Increased plasma bilirubin levels significantly.
Increased plasma alkaline phosphatase activity significantly.
Increased plasma alanine aminotransferase activity.
Increased plasma aspartate aminotransferase activity significantly.
Decreased testicular ascorbic acid levels significantly.
Decreased testicular glutathione levels significantly.
Decreased testicular superoxide dismutase activity significantly.
Decreased testicular catalase activity significantly.
Decreased testicular glutathione-S transferase activity significantly.
Increased testicular malondialdehyde levels significantly.
Decreased testicular acid phosphatase and γ-glutamyl transferase activities significantly in a dose-dependent manner.
Increased testicular lactate dehydrogenase activity significantly in a dose-dependent manner across all treatment groups.
Caused congestion of vessels in the tunica albuginea.
Molecular Weight

383.36

Formula

C19H20F3NO4
CAS No.
Appearance

Liquid (Density: 1.21 g/cm3)

Color

Colorless to light yellow

SMILES

C[C@@H](OC1=CC=C(OC2=NC=C(C(F)(F)F)C=C2)C=C1)C(OCCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (260.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6085 mL 13.0426 mL 26.0851 mL
5 mM 0.5217 mL 2.6085 mL 5.2170 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (6.52 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.52 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
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%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6085 mL 13.0426 mL 26.0851 mL 65.2129 mL
5 mM 0.5217 mL 2.6085 mL 5.2170 mL 13.0426 mL
10 mM 0.2609 mL 1.3043 mL 2.6085 mL 6.5213 mL
15 mM 0.1739 mL 0.8695 mL 1.7390 mL 4.3475 mL
20 mM 0.1304 mL 0.6521 mL 1.3043 mL 3.2606 mL
25 mM 0.1043 mL 0.5217 mL 1.0434 mL 2.6085 mL
30 mM 0.0870 mL 0.4348 mL 0.8695 mL 2.1738 mL
40 mM 0.0652 mL 0.3261 mL 0.6521 mL 1.6303 mL
50 mM 0.0522 mL 0.2609 mL 0.5217 mL 1.3043 mL
60 mM 0.0435 mL 0.2174 mL 0.4348 mL 1.0869 mL
80 mM 0.0326 mL 0.1630 mL 0.3261 mL 0.8152 mL
100 mM 0.0261 mL 0.1304 mL 0.2609 mL 0.6521 mL
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Fluazifop-P-butyl Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluazifop-P-butyl79241-46-6Acetyl-CoA CarboxylaseEnvironmental PollutantsHerbicideACC, Acetyl Coenzyme A Carboxylase Environmental ContaminantsZea mays var. saccharata L. cv. Z?ota Kar?owaoxidative stressornithine decarboxylasepolyaminemale Wistar ratsanthocyaninphotosynthetic pigmentmalonyl-CoAacetyl-CoA carboxylasemaize seedlingsInhibitorinhibitorinhibit

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