DL-Allylglycine
Based on 1 Customer Validation
DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine significantly increases mouse brain ornithine decarboxylase (ODC) activity and decreases S-adenosyl-L-methionine decarboxylase (SAM-DC) activity. DL-Allylglycine causes a marked decrease in brain GABA concentration. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 7685-44-1
- Formula: C5H9NO2
- Molecular Weight:115.13
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Glutamate Decarboxylase (GAD)[1]
DL-Allylglycine (30-40 mg/kg, i.v., once) induces stable photosensitivity with photically induced seizures in lateral geniculate body (GL)-kindled cats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male NMRI strain mice (weighing approx 32 g)[1]
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Dosage:0.8 mmol/kg
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Administration:i.p., single dose
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Result:Achieved a increase in mouse brain ornithine decarboxylase (ODC) activity, and a reduction in S-adenosyl-L-methionine decarboxylase (SAM-DC) activity.
Showed no significant changes in mouse liver ODC activity, but achieved a reduction in liver SAM-DC activity.
Induced a slight initial drop in mouse brain putrescine concentration.
Inhibited mouse brain glutamate decarboxylase (GAD) activity.
Lowered mouse rectal temperature (Trec).
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Animal Model:Adult cats (2.5-4 kg)[2]
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Dosage:30, 40 mg/kg
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Administration:i.v., once
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Result:Induced photically induced seizures (grade +1 to +4).
Elicited a total of 6 generalized tonic-clonic convulsions (GTCs) in 3 GL-kindled cats.
Triggered rhythmic spike and wave or polyspikes and wave discharges.
Induced spontaneous myoclonic movements with paroxysmal discharges.
Led to tachypnea and slight heart rate increase immediately.
Chemical Information
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CAS No. 7685-44-1
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Appearance Solid
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Molecular Weight 115.13
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Formula C5H9NO2
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Color White to off-white
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Synonyms
2-Aminopent-4-enoic acid
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 5.41 mg/mL (46.99 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Pajunen AE, et al. The effect of DL-allylglycine on polyamine and GABA metabolism in mouse brain. J Neurochem. 1979 May;32(5):1401-8. [Content Brief]
[2]. Wada Y, et al. Effects of allylglycine on photosensitivity in the lateral geniculate-kindled cat. Exp Neurol. 1986 Oct;94(1):228-36. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 8.6858 mL | 43.4292 mL | 86.8583 mL | 217.1458 mL |
| 5 mM | 1.7372 mL | 8.6858 mL | 17.3717 mL | 43.4292 mL | |
| 10 mM | 0.8686 mL | 4.3429 mL | 8.6858 mL | 21.7146 mL | |
| 15 mM | 0.5791 mL | 2.8953 mL | 5.7906 mL | 14.4764 mL | |
| 20 mM | 0.4343 mL | 2.1715 mL | 4.3429 mL | 10.8573 mL | |
| 25 mM | 0.3474 mL | 1.7372 mL | 3.4743 mL | 8.6858 mL | |
| 30 mM | 0.2895 mL | 1.4476 mL | 2.8953 mL | 7.2382 mL | |
| 40 mM | 0.2171 mL | 1.0857 mL | 2.1715 mL | 5.4286 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
DL-Allylglycine Related Classifications
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