DDC Protein, Human

DDC protein plays a central role in neurotransmitter synthesis by catalyzing the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to produce dopamine and L-5-hydroxytryptophan to produce serotonin. DDC Protein, Human is the recombinant human-derived DDC protein, expressed by E. coli , with tag free.

Human aromatic L-amino acid decarboxylase (hDDC) is an enzyme that plays a crucial role in neurotransmitter biosynthesis by catalyzing the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin. This enzymatic activity is a pivotal step in the synthesis of two key neurotransmitters, dopamine and serotonin, both of which are essential for the central nervous system's regulation of mood, behavior, and motor functions. The conversion of DOPA to dopamine by hDDC is particularly significant in the dopaminergic pathways, influencing motor control and emotional processes. The parallel conversion of L-5-hydroxytryptophan to serotonin underscores hDDC's role in serotoninergic pathways, crucial for mood and emotional regulation. It has to emphasize hDDC's specific contributions to neurotransmitter synthesis, highlighting its importance in maintaining the delicate balance of signaling molecules critical for neurological functions.

Human

E. coli

Tag Free

P20711 (M1-E480)

1644

Full Length

MNASEFRRRGKEMVDYMANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE

≥ 90%, as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl (pH 8.0), 200 mM NaCl, 1 mM DTT, 5% glycerol.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.