Search Result
Results for "
Fats
" in MedChemExpress (MCE) Product Catalog:
9
Biochemical Assay Reagents
40
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W588293
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- HY-P5275
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CG-Lipoxyn
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NF-κB
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Metabolic Disease
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Tripeptide-41(CG-Lipoxyn)isa bioactive peptide withreduce fat accumulationeffect and has been reported used as a cosmetic ingredient .
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- HY-P1067A
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Endogenous Metabolite
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Metabolic Disease
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Enterostatin (human,mouse,rat) TFA is a pentapeptide mainly formed in the intestine by the cleavage of secreted pancreatic procolipase. Enterostatin selectively reduces fat intake, bodyweight, and body fat in vivo .
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- HY-P3704
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Endogenous Metabolite
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Metabolic Disease
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Enterostatin (rat), an orally active activation peptide of procolipase, selectively reduces fat intake. Enterostatin (rat) reduces serum cholesterol levels by way of a CCK1 receptor-dependent mechanism .
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- HY-N9535
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Others
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Metabolic Disease
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tert-OMe-byakangelicin is a coumarin that can enhances the adrenaline-induced lipolytic effect and inhibits insulin-stimulated triglyceride synthesis from glucose in fat cells .
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- HY-135505
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Acyltransferase
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Metabolic Disease
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JTP-103237 is a MGAT2 inhibitor (IC50: 0.019 μM and 6.423 μM for hMGAT2 and hMGAT3 respectively). JTP-103237 modulates fat absorption, decreases plasma glucose levels and prevents diet-induced obesity .
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- HY-D1353
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Fluorescent Dye
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Others
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LipidGreen 2 is a second generation small molecule probe for lipid imaging. LipidGreen 2 has a better fluorescence signal compared with the previous LipidGreen, and selectively stains neutral lipids in cells and fat deposits in live zebrafish .
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- HY-N10755
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PGE synthase
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Metabolic Disease
Inflammation/Immunology
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(+)-ε-Viniferin is a stilbenes compound with PGE2 inhibition effect, and is an orally active anti-inflammatory agent. ε-viniferin is also able to reduce fat accumulation, thus can be used for research of inflammation or obesity .
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- HY-W051298
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Stearic diglyceride
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Biochemical Assay Reagents
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Metabolic Disease
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Distearin is a diacylglycerol containing stearic acid at two positions. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils .
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- HY-143712
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Endogenous Metabolite
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Metabolic Disease
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Allolithocholic acid is a steroid acid could found in normal serum and feces. Allolithocholic acid facilitates excretion, absorption, and transport of fats and sterols in the intestine and liver .
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- HY-120872
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Others
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Metabolic Disease
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AJS1669 free acid is a potent and orally available glycogen synthase (GS) activator. AJS1669 improves glucose metabolism and reduces body fat mass in mice[1].
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- HY-138843
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- HY-P3579
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GIP (1-42), porcine
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Insulin Receptor
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Endocrinology
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Gastric Inhibitory Peptide, porcine is a glucose-dependent insulinotropic polypeptide, is a 42 amino acid intestinal hormone with effects on fat and glucose metabolism .
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- HY-138843A
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- HY-125096
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Glucocorticoid Receptor
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Metabolic Disease
Inflammation/Immunology
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C108297 is a selective glucocorticoid receptor (GR) modulator (GR binding Ki 0.7 nM; GR reporter gene functional Ki 0.6 nM). C108297 attenuates obesity by reducing caloric intake and increasing lipolysis and fat oxidation, and in addition attenuates inflammation .
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- HY-135737
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Others
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Others
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Dicaprylyl carbonate, a solid, plant-derived fat, is a dry emollient. Dicaprylyl carbonate has excellent dermatological compatibility and a comprehensive performance profile, such as solubilizing and dispersing ability for sun-care filters .
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- HY-134577
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Adrenergic Receptor
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Endocrinology
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Clorprenaline is a potent agonist of β2-adrenergic. Clorprenaline promotes animal muscular mass growth and decreases fat accumulation. Clorprenaline is a potential new lean meat-boosting feed additive .
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- HY-152199
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Adenosine Deaminase
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Metabolic Disease
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AMPD2 inhibitor 2 (compound 21) is a potent AMP deaminase 2 (AMPD2) inhibitor with IC50s of 0.1 μM and 0.28μM for hAMPD2 and mAMPD2, respectively. AMPD2 inhibitor 2 has the potential for evaluating the physiological role of AMPD2 in mice maintained on a high fat diet .
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- HY-131370B
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Others
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Cancer
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Intralipid 20% is a safe fat emulsion that can be used as a nutritional supplement. Intralipid 20% effectively inhibits the opening of the mitochondrial permeability transition pore, effectively protecting the heart from ischaemia-reperfusion injury and has some potential to modulate the innate immune response .
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- HY-17462
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(+)-Adrenosterone
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Androgen Receptor
Endogenous Metabolite
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Endocrinology
Cancer
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Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor.
Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .
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- HY-W042416
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DMAc
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Biochemical Assay Reagents
NF-κB
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Neurological Disease
Metabolic Disease
Inflammation/Immunology
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N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease .
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- HY-15671
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Glucokinase
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Metabolic Disease
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GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose). GKA50 stimulates insulin release from mouse islets of Langerhans. GKA50 is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca 2+-dependent modulator of insulin secretion. GKA50 shows significant glucose lowering in high fat fed female rats .
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- HY-15671A
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Glucokinase
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Metabolic Disease
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GKA50 quarterhydrate is a potent glucokinase activator (EC50=33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca 2+-dependent modulator of insulin secretion. GKA50 quarterhydrate shows significant glucose lowering in high fat fed female rats .
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- HY-131448
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Others
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Metabolic Disease
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A3051 is a potent and orally active inhibtor of CXXC5-DVL extracted from patent WO2020079569, has an IC50 of 63.06 nM. A3334 can be used for the research of high fat diet (HFD)-induced and methionine-choline deficient diet (MCD)-induced phenotypes such as obesity, diabetes, and NASH .
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- HY-156405
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Fat Mass and Obesity-associated Protein (FTO)
Autophagy
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Metabolic Disease
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FTO-IN-10 (compound 7) is a potent human demethylase FTO (the fat mass and obesity-associated protein) inhibitor with an IC50 of 4.5 μM. FTO-IN-10 enters the FTO’s structural domain II binding pocket through hydrophobic and hydrogen bonding interactions. FTO-IN-10 induces DNA damage and autophagic cell death in A549 cells .
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- HY-Y0781S1
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Acetylformic acid-13C
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Endogenous Metabolite
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Others
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Pyruvic acid- 13C is the 13C labeled Pyruvic acid[1]. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats[2].
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- HY-Y0781S3
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Acetylformic acid-13C-2 sodium
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Endogenous Metabolite
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Others
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Pyruvic acid- 13C-2 (sodium) is the 13C labeled Pyruvic acid[1]. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats[2].
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- HY-Y0781S5
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Endogenous Metabolite
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Others
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Pyruvic acid- 13C,d4 is the deuterium and 13C labeled Pyruvic acid[1]. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats[2].
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- HY-RS04760
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Small Interfering RNA (siRNA)
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Others
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FAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for FAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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FAT1 Human Pre-designed siRNA Set A
FAT1 Human Pre-designed siRNA Set A
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- HY-RS04761
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Small Interfering RNA (siRNA)
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Others
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FAT2 Human Pre-designed siRNA Set A contains three designed siRNAs for FAT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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FAT2 Human Pre-designed siRNA Set A
FAT2 Human Pre-designed siRNA Set A
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- HY-RS04762
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Small Interfering RNA (siRNA)
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Others
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FAT3 Human Pre-designed siRNA Set A contains three designed siRNAs for FAT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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FAT3 Human Pre-designed siRNA Set A
FAT3 Human Pre-designed siRNA Set A
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- HY-RS04763
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Small Interfering RNA (siRNA)
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Others
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FAT4 Human Pre-designed siRNA Set A contains three designed siRNAs for FAT4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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FAT4 Human Pre-designed siRNA Set A
FAT4 Human Pre-designed siRNA Set A
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- HY-B1131
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Sodium taurocholate hydrate; N-Choloyltaurine sodium salt hydrate
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Endogenous Metabolite
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Inflammation/Immunology
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Taurocholic acid sodium salt hydrate (Sodium taurocholate hydrate) is a bile acid involved in the emulsification of fats.
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- HY-Y0781
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Acetylformic acid
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Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.
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- HY-P1067
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- HY-101699A
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MCHR1 (GPR24)
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Metabolic Disease
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AMG-076 is an orally bioavailable and selective MCHR1 antagonist. AMG-076 results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice .
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- HY-145238
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- HY-113016
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- HY-139820
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- HY-139821
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- HY-B2219
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- HY-110197
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Others
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Metabolic Disease
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6bK TFA is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM. 6bK TFA increases circulating insulin in high-fat-fed mice. Acute administration of 6bK TFA enhances glucose tolerance to oral glucose, notably to a greater extent in high-fat-fed mice .
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- HY-B2219A
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- HY-N2041
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Endogenous Metabolite
NF-κB
Bacterial
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Infection
Inflammation/Immunology
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Myristic acid is an orally active saturated 14-carbon fatty acid found in most animal and plant fats, especially milk fat coconut oil, palm oil and nutmeg oil. Myristic acid exerts anti-inflammatory activity through the NF-κB pathway. Myristic acid has antibacterial, anti-inflammatory and analgesic properties .
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- HY-B1788S
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N-Choloyltaurine-d4 (sodium)
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Endogenous Metabolite
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Inflammation/Immunology
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Taurocholic acid-d4 (sodium) is the deuterium labeled Taurocholic acid. Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.
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- HY-Y0781S
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Acetylformic acid-13C (sodium)
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Endogenous Metabolite
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Others
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Pyruvic acid- 13C (sodium) is the 13C-labeled Pyruvic acid. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.
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- HY-B1788S1
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- HY-N7074
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Bacterial
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Inflammation/Immunology
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Lanolin is a yellow fat obtained from sheep's wool. Lanolin is used topically for sore, cracked nipples during breastfeeding .
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- HY-139994
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- HY-N0378
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Mannitol; Mannite
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Endogenous Metabolite
Apoptosis
Adrenergic Receptor
PGC-1α
PKA
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Metabolic Disease
Cancer
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D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells .
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- HY-D0932
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Solvent Red 24; C.I. 26105
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Sudan IV is a lysochrome (fat-soluble dye) diazo dye used for the staining of lipids, triglycerides and lipoproteins on frozen paraffin sections .
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- HY-101900
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Nile blue sulfate
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Fluorescent Dye
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Others
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Nile Blue A (Nile blue sulfate) is used to differentiate melanins and lipofuscins. It is also useful for staining fats and preparation of an amperometric glucose sensor .
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- HY-W753983
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Acetylformic acid-13C3
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Isotope-Labeled Compounds
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Metabolic Disease
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Pyruvic acid-13C is isotype-labeled compound of Pyruvic acid. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats .
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- HY-124557
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- HY-D0213
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Fluorescent Dye
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Others
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Sudan Black B, a fat-soluble diazo dye, is a histochemical stain. Sudan Black B can be used for staining of neutral triglycerides and lipids .
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- HY-B0896S1
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Glyceryl triacetate-d5; 1,2,3-Triacetoxypropane-d5
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Isotope-Labeled Compounds
Fungal
Endogenous Metabolite
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Triacetin-d5 is the deuterium labeled Triacetin. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
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- HY-B2219S8
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- HY-P3570
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Lom-AKH-II
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Endogenous Metabolite
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Metabolic Disease
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Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs) .
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- HY-P3572
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Lom-AKH-I
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Endogenous Metabolite
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Endocrinology
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Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs) .
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- HY-N0324
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Endogenous Metabolite
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Metabolic Disease
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Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active .
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- HY-N0324A
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Sodium cholate
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Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid sodium is orally active .
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- HY-14811
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ZGN-440; CKD-732 free base
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MetAP
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Metabolic Disease
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Beloranib is a fumagillin-class methionine aminopetidase-2 (MetAP2) inhibitor. Beloranib decreases food intake, body weight, fat mass, and the size of adipocytes.
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- HY-W012974
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- HY-B2219S3
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- HY-B2219S1
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- HY-124141
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trans-9-Tetradecenoic acid
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Endogenous Metabolite
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Metabolic Disease
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Myristelaidic acid (trans-9-Tetradecenoic acid), a 14-carbon trans fatty acid, is the trans isomer of Myristoleic acid. Myristelaidic acid is found in most animal fats .
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- HY-B2219S4
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- HY-B2219S6
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- HY-B2219S9
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Endogenous Metabolite
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Stearic acid-d7 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-N0324B
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Endogenous Metabolite
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Metabolic Disease
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Cholic acid sodium hydrate is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid sodium hydrate facilitates fat absorption and cholesterol excretion. Cholic acid sodium hydrate is orally active .
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- HY-101832
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- HY-157734
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Others
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Others
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1,2-Palmitate-3-elaidate is a triglyceride that can be isolated from virgin olive oil .
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- HY-N2334
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Chenodeoxycholylglycine
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Endogenous Metabolite
Apoptosis
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Cancer
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Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis .
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- HY-B2219S2
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- HY-B0896S2
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Fungal
Endogenous Metabolite
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Others
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Glyceryl Triacetate-d9 is the deuterium labeled Triacetin[1]. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
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- HY-113016R
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Endogenous Metabolite
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Metabolic Disease
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Elaidic acid (Standard) is the analytical standard of Elaidic acid. This product is intended for research and analytical applications. Elaidic acid is the major trans fat found in hydrogenated vegetable oils and can be used as a pharmaceutical solvent.
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- HY-N0324S
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Endogenous Metabolite
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Metabolic Disease
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Cholic acid-d4 is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
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- HY-N0324S1
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Endogenous Metabolite
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Metabolic Disease
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Cholic acid-d5 is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
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- HY-N2334A
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Chenodeoxycholylglycine sodium salt; Sodium glycochenodeoxycholate
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Endogenous Metabolite
Apoptosis
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Cancer
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Glycochenodeoxycholic (GCDC) acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis .
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- HY-N4219
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Others
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Neurological Disease
Metabolic Disease
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Saikosaponin B3 is a saikosaponin isolated from the roots of Bupleurum falcatum L., with analgesic effect. Saikosaponin B3 inhibits ACTH-induced lipolysis in the fat cells .
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- HY-B2219S
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- HY-N0324S2
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Endogenous Metabolite
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Metabolic Disease
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Cholic acid- 13C is the 13C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
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- HY-B2219S7
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- HY-N2041S5
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Isotope-Labeled Compounds
Endogenous Metabolite
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Myristic acid-d is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-B2219R
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Endogenous Metabolite
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Metabolic Disease
Cancer
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Stearic acid (Standard) is the analytical standard of Stearic acid. This product is intended for research and analytical applications. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-115319
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Ferroptosis
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Inflammation/Immunology
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CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research .
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- HY-135297
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Biochemical Assay Reagents
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Others
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Mono-and diglycerides is formed by triglycerides being broken down by pancreatic lipase in the gastrointestinal lumen. Mono-and diglycerides is a food additive used as a nonionic emulsifier and mainly present in food fats .
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- HY-N2041S2
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Endogenous Metabolite
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Others
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Myristic acid- 13C the 13C is labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-118634
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R-4G
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FATP
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Metabolic Disease
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Trans-Resveratrol-4'-O-D-Glucuronide (R-4G) is a metabolite of resveratrol with anti-fat accumulation property, and can be used for metabolic research .
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- HY-B2219S5
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Endogenous Metabolite
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Metabolic Disease
Cancer
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Stearic acid-9,10-d2 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-N2041S4
-
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Endogenous Metabolite
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Others
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Myristic acid- 13C3 is the 13C labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-N2041S3
-
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Endogenous Metabolite
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Others
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Myristic acid-d33 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-N2041S
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Endogenous Metabolite
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Others
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Myristic acid-d27 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-108521
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RAR/RXR
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Metabolic Disease
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HX531 is a potent RXR antagonist with an IC50 of 18 nM . It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet .
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- HY-N2041S1
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Isotope-Labeled Compounds
Endogenous Metabolite
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Myristic acid-d2 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-N2041S6
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Endogenous Metabolite
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Myristic acid-d5 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-N2041S7
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Isotope-Labeled Compounds
Endogenous Metabolite
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Myristic acid-d7 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-N8144
-
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Others
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Cardiovascular Disease
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Niga-ichigoside F1, an orally active ursane triterpenoid, has antihyperlipidemic and antioxidant activities. Niga-ichigoside F1 can prevent high-fat diet (HFD)-induced hepatic steatosis .
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- HY-B0234
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Estrone
3 Publications Verification
E1; Oestrone
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Estrogen Receptor/ERR
Endogenous Metabolite
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Endocrinology
Cancer
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Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells .
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- HY-N10340
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Clauszoline I
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Others
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Cancer
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Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells.
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- HY-N0723
-
|
Others
|
Metabolic Disease
|
Neomangiferin is a natural C-glucosyl xanthone isolated from m the dried rhizome of Anemarrhena asphodeloides. Neomangiferin has significant therapeutic effects on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) in rats .
|
-
- HY-W127711
-
|
Fluorescent Dye
|
Others
|
Fast Blue B Salt is a coloring agent that dissolves fats and phenolic compounds extracted from rye, as well as diazonium. Fast Blue B Salt can be used for the semiquantification of alkylresorcinols in rye and produces a color precipitate in the presence of acetone .
|
-
- HY-149334
-
-
- HY-N7075
-
Inulin
2 Publications Verification
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
Inulin is a storage polysaccharide and belongs to a group of non-digestible carbohydrates, fructan. Inulin is from plants of the Compositae and Lilialiaceaes families, often used as a prebiotic, fat replacer, sugar replacer, texture modifier, plays beneficial role in gastric .
|
-
- HY-157733
-
|
Others
|
Metabolic Disease
|
1,2-Dioleoyl-3-behenoylglycerol (BOO) inhibits pancreatic lipase activity. 1,2-Dioleoyl-3-behenoylglycerol prevents the deposition of visceral fat and hepatic triacylglycerol (TAG) .
|
-
- HY-B0511
-
Vitamin B7; Vitamin H; D-Biotin
|
Endogenous Metabolite
|
Metabolic Disease
|
Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
|
-
- HY-136408
-
Malonyl coenzyme A lithium
|
Mitochondrial Metabolism
|
Metabolic Disease
|
Malonyl CoA (Malonyl Coenzyme A) lithium is an inhibitor of carnitine palmitoyl transferase 1 (CPT1). High Malonyl CoA lithium concentrations suppress fatty acid oxidation, while low Malonyl CoA lithium concentrations are permissive for fat oxidation .
|
-
- HY-B0191A
-
5,6-trans-AGN 192024
|
Others
|
Endocrinology
Cancer
|
5,6-trans-Bimatoprost is the isomer of Bimatoprost (HY-B0191), and can be used as an experimental control. Bimatoprost is a prostaglandin analogue that can be used in studies of ocular hypertension and glaucoma and also has anti-fat formation effects.
|
-
- HY-N0324R
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Cholic acid (Standard) is the analytical standard of Cholic acid. This product is intended for research and analytical applications. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active .
|
-
- HY-B1320
-
Meclofenamate sodium
|
|
|
Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities .
|
-
- HY-N2334AS
-
Chenodeoxycholylglycine-d7 (sodium); Sodium glycochenodeoxycholate-d7
|
Endogenous Metabolite
Apoptosis
|
Cancer
|
Glycochenodeoxycholic acid-d7 (sodium) is the deuterium labeled Glycochenodeoxycholic acid (sodium salt). Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis[1][2].
|
-
- HY-N2334S
-
Chenodeoxycholylglycine-d4
|
Endogenous Metabolite
Apoptosis
|
Cancer
|
Glycochenodeoxycholic acid-d4 is the deuterium labeled Glycochenodeoxycholic acid. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis[1][2].
|
-
- HY-Y1242
-
|
|
|
Choline hydroxide is a Choline hydrogen oxidized derivative and a strong organic base, can be used as the standard alkaline to adjust the pH of the medium. Choline is an orally active nutrient, serves as an important component of lecithin and sphingomyelin, promotes fat metabolism .
|
-
- HY-N0898A
-
(-)-Cianidanol; (-)-Catechuic acid
|
COX
|
Cancer
|
(-)-Catechin is Catechin's one kind of different structure. Catechin inhibitory enzyme-1 (COX-1), IC50 为 1.4 μM. (-)-Catechin promotes hBM-MSC adipose cell differentiation, increases fat cell differentiation, and PPARγ level.
|
-
- HY-101082
-
|
|
|
N6,2′-O-Dimethyladenosine, a substrate of fat mass and obesity-associated gene (FTO), is a reversible modification widely occurred on varied RNA molecules. N6,2′-O-Dimethyladenosine can regulate obesity .
|
-
- HY-113926
-
|
Guanylate Cyclase
|
Cardiovascular Disease
|
BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect .
|
-
- HY-112340
-
|
Cannabinoid Receptor
|
Metabolic Disease
|
CB1 antagonist 4 (compound 8) is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist. CB1 antagonist 4 shows limited penetrance to the brain in order to minimize or prevent CNS adverse reactions, and preserves potential antiobesity effects. CB1 antagonist 4 reduces propensity for psychiatric side effects .
|
-
- HY-B0511A
-
Vitamin B7 sodium; Vitamin H sodium; D-Biotin sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
Biotin (Vitamin B7) sodium is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin sodium is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
|
-
- HY-151106
-
-
- HY-B0757A
-
Vitamin E Nicotinate
|
Reactive Oxygen Species
Endogenous Metabolite
|
Cardiovascular Disease
|
(±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases .
|
-
- HY-123494
-
|
Others
|
Cardiovascular Disease
Neurological Disease
|
BRD0418 is a diversity-oriented synthesis (DOS) molecule that regulates the expression of tribbles pseudokinase 1. BRD0418 has the effect of causing hot lipoprotein metabolism from fat production to clearance. BRD0418 can be used in the study of coronary artery disease (CAD) .
|
-
- HY-B0234S1
-
E1-d2; Oestrone-d2
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
Endocrinology
Cancer
|
Estrone-d2 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
|
-
- HY-N7072
-
|
Apoptosis
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells .
|
-
- HY-B0234S2
-
E1-d4; Oestrone-d4
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
Endocrinology
Cancer
|
Estrone-d4 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
|
-
- HY-B0234S4
-
E1-d2-1; Oestrone-d2-1
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
Endogenous Metabolite
|
|
Estrone-d2-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
|
-
- HY-B0234S
-
E1-13C3; Oestrone-13C3
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
Endocrinology
Cancer
|
Estrone- 13C3 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
|
-
- HY-12317
-
|
Smo
Hedgehog
|
Cancer
|
GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development .
|
-
- HY-B0234S3
-
E1-13C2; Oestrone-13C2
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
Endogenous Metabolite
|
Endocrinology
Cancer
|
Estrone- 13C2 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
|
-
- HY-B0234R
-
E1(Standard); Oestrone (Standard)
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
Endocrinology
Cancer
|
Estrone (Standard) is the analytical standard of Estrone. This product is intended for research and analytical applications. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells .
|
-
- HY-W093183
-
Palmitic acid anhydride
|
Biochemical Assay Reagents
|
Others
|
Palmitic anhydride, a saturated fatty acid found in many natural sources such as animal fats and vegetable oils, is commonly used as a reagent in organic synthesis to introduce palmitoyl(hexadecanoyl) functional groups into other organic molecules, moreover, Palmitic anhydride has been Used in the production of surfactants, lubricants and plasticizers, as well as in the preparation of cosmetics and pharmaceuticals.
|
-
- HY-117275S1
-
Meclofenamate-13C6
|
Isotope-Labeled Compounds
Gap Junction Protein
Endogenous Metabolite
|
Inflammation/Immunology
|
Meclofenamic acid- 13C6 is the 13C6 labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.
|
-
- HY-147246
-
HTD1801; BUDCA
|
Others
|
Metabolic Disease
|
Berberine ursodeoxycholate (HTD1801), an ionic salt of Berberine and Ursodeoxycholic acid, is an orally active and potent hypolipidemic agent. Berberine ursodeoxycholate shows significantly great reduction in liver fat content. Berberine ursodeoxycholate has a broad spectrum of metabolic activity. Berberine ursodeoxycholate can be used for the research of hyperlipidemia, non-alcoholic steatohepatitis (NASH) and diabetes .
|
-
- HY-14234
-
|
Glucocorticoid Receptor
|
Metabolic Disease
Inflammation/Immunology
Endocrinology
|
Glucocorticoid receptor agonist is a Glucocorticoid receptor agonist that acts on Glucocorticoid receptor (GR), progesterone receptor (PR) and mineralocorticoid receptor (MR) with the IC50 values of 2.1 , 1200 and 210 nM, respectively. Glucocorticoid receptor agonist has steroid-like anti-inflammatory properties and may be used to improve metabolism and reduce increased levels of body fat and serum insulin .
|
-
- HY-117275S
-
Meclofenamate-d4
|
Isotope-Labeled Compounds
Gap Junction Protein
Endogenous Metabolite
|
Inflammation/Immunology
|
Meclofenamic acid-d4 is the deuterium labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker[1][2][3].
|
-
- HY-123033A
-
|
Sirtuin
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
Cancer
|
Nicotinamide riboside Chloride, an orally active NAD + precursor, increases NAD + levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .
|
-
- HY-123033
-
|
Sirtuin
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
Cancer
|
Nicotinamide riboside, an orally active NAD + precursor, increases NAD + levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .
|
-
- HY-115914
-
|
Others
|
Others
|
Lipid-lowering agent-1 is a potent lipid-lowering agent. Lipid-lowering agent-1 has significant pharmacological effects on the inhibition of low-density lipoprotein cholesterol (LDLC) and promotion of high-density lipoprotein cholesterol (HDLC) production. Lipid-lowering agent-1 shows potent hypolipidemic effect in high-fat diet rats .
|
-
- HY-N7347
-
Garcinia lactone
|
ATP Citrate Lyase
|
Metabolic Disease
|
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .
|
-
- HY-N4137
-
-
- HY-135259
-
-
- HY-N1993
-
|
|
|
5-Methyl-7-methoxyisoflavone is a non-steroidal anabolic isoflavone. 5-Methyl-7-methoxyisoflavone shows potency increasing muscle mass and endurance. 5-Methyl-7-methoxyisoflavone can be used for fat loss, increase vitality and muscle gain besides the maintenance of low cholesterol level and strengthen bones .
|
-
- HY-W009544
-
3-Hydroxymyristic acid
|
Biochemical Assay Reagents
|
Others
|
3-Hydroxytetradecanoic acidis a saturated fatty acid. 3-Hydroxytetradecanoic acidOccurs naturally in various animal and plant sources such as butter and milk fat. 3-Hydroxytetradecanoic acidIt has various uses in industry, especially in the production of soaps, detergents and other surfactants. 3-Hydroxytetradecanoic acidIt is also used as a precursor for the synthesis of other bioactive compounds such as antibiotics and anticancer drugs.
|
-
- HY-W012974S
-
|
Endogenous Metabolite
|
|
3-Amino-2-methylpropanoic acid-d3 is the deuterium labeled 3-Amino-2-methylpropanoic acid[1]. 3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors[2].
|
-
- HY-123033B
-
|
Sirtuin
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
Cancer
|
Nicotinamide riboside tartrate, an orally active NAD + precursor, increases NAD + levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .
|
-
- HY-123033C
-
|
Sirtuin
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
Cancer
|
Nicotinamide riboside malate, an orally active NAD + precursor, increases NAD + levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .
|
-
- HY-D1168
-
|
Fluorescent Dye
|
Metabolic Disease
|
Oil Red O is a fat-soluble diazol dye, with a maximum absorption at 518 nm. Oil Red O stains neutral lipids and cholesteryl esters but not biological membranes. Oil Red O can be used for detecting and quantifying hepatic steatosis in mouse liver biopsies. Oil Red O staining efficiently helps to visualize the radical changes that occur in tissues as metabolic disease occurs and progresses .
|
-
- HY-153812
-
AST070
|
Others
|
Metabolic Disease
|
AST 7062601 (AST070) is a Ucp1 inducer that strongly induces endogenous Ucp1 expression in primary mouse brown adipocytes. Ucp1 refers to uncoupling protein, found in brown and beige fat cells. In mammals, UCP1 oxidizes fatty acids and uncouples ATP production in mitochondria to promote energy dissipation as heat. AST 7062601 can be used to study thermogenic, uncoupled respiration .
|
-
- HY-112533
-
11d-11m-PGD2; 11-Deoxy-11-Methylene prostaglandin D2
|
Others
|
Endocrinology
|
11-Deoxy-11-methylene PGD2 (11d-11m-PGD2) is a chemically stable, isosteric analogue of Prostaglandin 2 in which the 11-keto group is replaced by an exocyclic methylene. 11-Deoxy-11-methylene PGD2 is significantly stimulating the storage of fats suppressed in the presence of Indomethacin .
|
-
- HY-115369
-
|
Biochemical Assay Reagents
|
Others
|
cis-13,16,19-Docosatrienoic acid methyl ester is an ester form of docosatrienoic acid, a rare omega-3 fatty acid not found in the normal phospholipid polyunsaturated fatty acid pool Easily detectable, it inhibits the binding of [3H]-LTB4 to porcine neutrophils at a concentration of 5 μM. Methyl docosatrienoate is more fat-soluble than the free acid and may be more desirable than the free acid in some formulations.
|
-
- HY-N6769
-
Monorden
|
HSP
Bacterial
Antibiotic
Parasite
|
Infection
|
Radicicol is an inhibitor of Hsp90 with an IC50 value < 1 μM, and leads to proteasomal degradation . Radicicol exhibits inhibition on PDK with IC50s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB . Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC50 value of 16.04 μM .
|
-
- HY-117275
-
-
- HY-117275A
-
-
- HY-133180
-
|
Wnt
β-catenin
|
Metabolic Disease
|
YW1128 (compound 3a) is a potent Wnt/β-Catenin inhibitor. YW1128 induces the proteasome degradation of β-catenin and subsequent inhibits the Wnt/β-catenin signaling in cells. YW1128 significantly decreases hepatic lipid accumulation. YW1128 improves glucose tolerance of high fat diet-fed mice without noticeable toxicity. YW1128 down regulates the genes involved in the glucose and fatty acid anabolism .
|
-
- HY-18555
-
TMPA
1 Publications Verification
|
Nuclear Hormone Receptor 4A/NR4A
AMPK
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPKα. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation .
|
-
- HY-131447
-
KY19382
1 Publications Verification
A3051
|
GSK-3
Wnt
β-catenin
|
Metabolic Disease
|
KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases .
|
-
- HY-123986
-
|
Mitochondrial Metabolism
|
Inflammation/Immunology
Cancer
|
CTPI-2 is a third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a KD of 3.5 μM. CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Antitumor activity .
|
-
- HY-155525
-
|
PPAR
|
Metabolic Disease
Inflammation/Immunology
|
Anti-NASH agent 1 (compound 3d),a derivative of Elafibranor (HY-16737),is a potent agonist of PPAR-α/δ,targeting to nonalcoholic steatohepatitis (NASH). Anti-NASH agent 1 (3-10 mg/kg; 4 weeks) improves hyperlipidemia,liver fat degeneration and liver inflammation in Methionine-choline deficiency (MCD) induced NASH mice model. Anti-NASH agent 1 shows low liver toxicity and potent liver protection effect .
|
-
- HY-135425
-
|
Acyltransferase
|
Metabolic Disease
|
10,12-Tricosadiynoic acid is a highly specific, selective, high affinity and orally active acyl-CoA oxidase-1 (ACOX1) inhibitor. 10,12-Tricosadiynoic acid can treat high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism . 10,12-Tricosadiynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-120978
-
ω-3 Arachidonic acid methyl ester; (all-Z)-8,11,14,17-Eicosatetraenoic acid methyl ester
|
Biochemical Assay Reagents
|
Others
|
omega-3 Arachidonic Acid methyl ester, mainly docosahexaenoic acid, eicosapentaenoic acid and α-Linoleic acid, represented by linoleic acid, is an essential dietary nutrient required for normal growth and development.Omega-3Methyl arachidonic acid is a rare fatty acid Omega-3Neutral fat-soluble form of arachidonic acid. Omega-3Fatty acids, as a group, were associated with reduced inflammation and autoimmune activity, as well as reduced thrombosis and platelet activation.
|
-
- HY-133971
-
5α,6α-Epoxycholesterol
|
Liposome
|
Others
|
Cholesterol-5α,6α-epoxide is an epoxide derivative of cholesterol formed by the enzymatic oxidation of cholesterol in the liver and other tissues. Cholesterol-5α,6α-epoxide has unique chemical properties that make it an important intermediate in the biosynthesis of bile acids, which play a key role in the digestion and absorption of dietary fats. It also has a potential physiological role in regulating cholesterol metabolism and transport, although its biological function is not fully understood.
|
-
- HY-P2048A
-
|
AMPK
GLUT
|
Metabolic Disease
|
MOTS-c(human) acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c(human) acetate induces glucose uptake and improves insulin sensitivity. MOTS-c(human) acetate has implications in the regulation of obesity, diabetes, exercise, and longevity .
|
-
- HY-P3578
-
|
Insulin Receptor
|
Endocrinology
|
Gastric Inhibitory Polypeptide (1-30), porcine lacks the C-terminal 12 amino acid residues of natural gastric inhibitory polypeptide (GIP), exhibits biologic activity by potentiating the release of insulin and somatostatin .
|
-
- HY-116538
-
trans-10,cis-12 CLA2
|
Endogenous Metabolite
PPAR
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
(10E,12Z)-Octadeca-10,12-dienoic acidactivates PPAR α and inhibits adipocyte differentiation . (10E,12Z)-Octadeca-10,12-dienoic acid and its downstream metabolites have various antioxidant and antitumor activities. (10E,12Z)-Octadeca-10,12-dienoic acid is effective orally .
|
-
- HY-N2181
-
|
|
|
Acetylshikonin is an oral active anti-cancer, anti-inflammatory, antioxidant, anti-fertility, antibacterial, and neuroprotective agent. Acetylshikonin is a inhibitor of acetylcholinase (AChE) (IC50=34.6 μM) and nonselective cytochrome P450. Acetylshikonin can induce Apoptosis and Autophagy in cancer cells. Acetylshikonin regulates blood glucose, liver fat metabolism, and renal fibrosis, and is used in the study of diabetes, diabetic nephropathy (DN), obesity, and nonalcoholic fatty liver disease (NAFLD) .
|
-
- HY-W127409
-
|
Biochemical Assay Reagents
|
Others
|
1,2-Dimyristoyl-rac-glycerol (C14:0) is a carboxylic acid ester, glycerolipid and diglyceride with an additional myristoyl group that facilitates interactions between proteins and lipids. Can be used as detergent or reagent. It plays a role in cell biology experiments involving the metabolism and metabolic pathways of glycerolipids. As a diglyceride, this substance consists of two fatty acid chains covalently bonded in the 1,2-form to a glycerol molecule. The diglyceride (DAG) study investigated the process by which DAG is depleted to inhibit fat accumulation. Reagent grade, for research use only.
|
-
- HY-12756A
-
|
|
|
E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) .
|
-
- HY-12756
-
E6446
1 Publications Verification
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Toll-like Receptor (TLR)
Stearoyl-CoA Desaturase (SCD)
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Metabolic Disease
Inflammation/Immunology
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E6446 is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) .
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- HY-130437
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MDM-2/p53
TGF-β Receptor
Caspase
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Infection
Metabolic Disease
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p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4].
non-alcoholic fatty liver disease .
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- HY-155517
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NOD-like Receptor (NLR)
Pyroptosis
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Inflammation/Immunology
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INF200 (compound 5) is a sulfonylurea-based inhibitor of NLRP3 and NLRP3-mediated pyroptosis. INF200 has beneficial cardiometabolic effects in rat model of high-fat diet (HFD)-induced metaflammation,and shows anti-inflammatory activity to (10 μM) decreases IL-1β release in human macrophages. INF200 improves glucose and lipid profiles,and attenuates systemic inflammation and biomarkers of cardiac dysfunction (particularly BNP). INF200 also improves myocardial damage-dependent ischemia/reperfusion injury (IRI) in hemodynamic evaluation .
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- HY-B1135
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- HY-10585A
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Sodium Valproate sodium
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Organoid
HDAC
Autophagy
Mitophagy
HIV
Notch
Apoptosis
Endogenous Metabolite
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Infection
Neurological Disease
Metabolic Disease
Cancer
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Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches .
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- HY-10585
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- HY-10585B
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VPA (sodium)(2:1); 2-Propylpentanoic Acid (sodium)(2:1)
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HDAC
Autophagy
Mitophagy
HIV
Notch
Apoptosis
Endogenous Metabolite
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Infection
Neurological Disease
Metabolic Disease
Cancer
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Valproic acid (VPA) sodium (2:1) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium (2:1) activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium (2:1) is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches .
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HY-L083
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2068 compounds
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Mutations in oncogenes and tumor suppressor genes can modify multiple signaling pathways and in turn cell metabolism, which facilitates tumorigenesis. The paramount hallmark of tumor metabolism is “aerobic glycolysis” or the Warburg effect, coined by Otto Warburg in 1926, in which cancer cells produce most of energy from glycolysis pathway regardless of whether in aerobic or anaerobic condition. Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside. The increased uptake of glucose is facilitated by the overexpression of several isoforms of membrane glucose transporters (GLUTs). Likewise, the metabolic pathways of glutamine, amino acid and fat metabolism are also altered. Recent trends in anti-cancer drug discovery suggests that targeting the altered metabolic pathways of cancer cells result in energy crisis inside the cancer cells and can selectively inhibit cancer cell proliferation by delaying or suppressing tumor growth.
MCE provides a unique collection of 2068 compounds which cover various tumor metabolism-related signaling pathways. These compounds can be used for anti-cancer metabolism targets identification, validation as well anti-cancer drug discovery.
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HY-L148
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65 compounds
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The TCA cycle (tricarboxylic acid cycle)—is also known as the Krebs cycle or the citric acid cycle (CAC). The TCA cycle is a series of chemical reactions that release stored energy through the oxidation of acetyl-CoA in carbohydrates, fats, and proteins.
For decades, the TCA cycle has been considered as the central pathway for cell oxidative phosphorylation to produce energy and biosynthesis. Research shows that TCA cycle is associated with many diseases, especially cancer. In colon carcinoma, liver cancer and other cancers, there are mutations that lead to the imbalance of TCA cycle metabolites, indicating that TCA cycle may be related to the occurrence of cancer. Understanding the role and molecular mechanism of TCA cycle in inhibiting or promoting cancer progression will promote the development of new metabolite-based cancer treatment methods in the future.
MCE supplies a unique collection of 65 compounds related to the TCA cycle. MCE TCA Cycle Compound Library is a useful tool for the TCA cycle related research and anti-cancer drug development.
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Cat. No. |
Product Name |
Type |
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- HY-D1353
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Fluorescent Dyes/Probes
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LipidGreen 2 is a second generation small molecule probe for lipid imaging. LipidGreen 2 has a better fluorescence signal compared with the previous LipidGreen, and selectively stains neutral lipids in cells and fat deposits in live zebrafish .
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- HY-101900
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Nile blue sulfate
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Fluorescent Dyes/Probes
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Nile Blue A (Nile blue sulfate) is used to differentiate melanins and lipofuscins. It is also useful for staining fats and preparation of an amperometric glucose sensor .
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- HY-D0213
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Dyes
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Sudan Black B, a fat-soluble diazo dye, is a histochemical stain. Sudan Black B can be used for staining of neutral triglycerides and lipids .
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- HY-D1168
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Fluorescent Dyes/Probes
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Oil Red O is a fat-soluble diazol dye, with a maximum absorption at 518 nm. Oil Red O stains neutral lipids and cholesteryl esters but not biological membranes. Oil Red O can be used for detecting and quantifying hepatic steatosis in mouse liver biopsies. Oil Red O staining efficiently helps to visualize the radical changes that occur in tissues as metabolic disease occurs and progresses .
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Cat. No. |
Product Name |
Type |
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- HY-W042416
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DMAc
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Co-solvents
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N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease .
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- HY-B0757A
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Vitamin E Nicotinate
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Biochemical Assay Reagents
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(±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases .
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- HY-W093183
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Palmitic acid anhydride
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Biochemical Assay Reagents
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Palmitic anhydride, a saturated fatty acid found in many natural sources such as animal fats and vegetable oils, is commonly used as a reagent in organic synthesis to introduce palmitoyl(hexadecanoyl) functional groups into other organic molecules, moreover, Palmitic anhydride has been Used in the production of surfactants, lubricants and plasticizers, as well as in the preparation of cosmetics and pharmaceuticals.
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- HY-W127711
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Biochemical Assay Reagents
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Fast Blue B Salt is a coloring agent that dissolves fats and phenolic compounds extracted from rye, as well as diazonium. Fast Blue B Salt can be used for the semiquantification of alkylresorcinols in rye and produces a color precipitate in the presence of acetone .
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- HY-W009544
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3-Hydroxymyristic acid
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Biochemical Assay Reagents
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3-Hydroxytetradecanoic acidis a saturated fatty acid. 3-Hydroxytetradecanoic acidOccurs naturally in various animal and plant sources such as butter and milk fat. 3-Hydroxytetradecanoic acidIt has various uses in industry, especially in the production of soaps, detergents and other surfactants. 3-Hydroxytetradecanoic acidIt is also used as a precursor for the synthesis of other bioactive compounds such as antibiotics and anticancer drugs.
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- HY-115369
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Biochemical Assay Reagents
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cis-13,16,19-Docosatrienoic acid methyl ester is an ester form of docosatrienoic acid, a rare omega-3 fatty acid not found in the normal phospholipid polyunsaturated fatty acid pool Easily detectable, it inhibits the binding of [3H]-LTB4 to porcine neutrophils at a concentration of 5 μM. Methyl docosatrienoate is more fat-soluble than the free acid and may be more desirable than the free acid in some formulations.
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- HY-120978
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ω-3 Arachidonic acid methyl ester; (all-Z)-8,11,14,17-Eicosatetraenoic acid methyl ester
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Biochemical Assay Reagents
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omega-3 Arachidonic Acid methyl ester, mainly docosahexaenoic acid, eicosapentaenoic acid and α-Linoleic acid, represented by linoleic acid, is an essential dietary nutrient required for normal growth and development.Omega-3Methyl arachidonic acid is a rare fatty acid Omega-3Neutral fat-soluble form of arachidonic acid. Omega-3Fatty acids, as a group, were associated with reduced inflammation and autoimmune activity, as well as reduced thrombosis and platelet activation.
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- HY-133971
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5α,6α-Epoxycholesterol
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Drug Delivery
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Cholesterol-5α,6α-epoxide is an epoxide derivative of cholesterol formed by the enzymatic oxidation of cholesterol in the liver and other tissues. Cholesterol-5α,6α-epoxide has unique chemical properties that make it an important intermediate in the biosynthesis of bile acids, which play a key role in the digestion and absorption of dietary fats. It also has a potential physiological role in regulating cholesterol metabolism and transport, although its biological function is not fully understood.
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- HY-W127409
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Biochemical Assay Reagents
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1,2-Dimyristoyl-rac-glycerol (C14:0) is a carboxylic acid ester, glycerolipid and diglyceride with an additional myristoyl group that facilitates interactions between proteins and lipids. Can be used as detergent or reagent. It plays a role in cell biology experiments involving the metabolism and metabolic pathways of glycerolipids. As a diglyceride, this substance consists of two fatty acid chains covalently bonded in the 1,2-form to a glycerol molecule. The diglyceride (DAG) study investigated the process by which DAG is depleted to inhibit fat accumulation. Reagent grade, for research use only.
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P5275
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CG-Lipoxyn
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NF-κB
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Metabolic Disease
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Tripeptide-41(CG-Lipoxyn)isa bioactive peptide withreduce fat accumulationeffect and has been reported used as a cosmetic ingredient .
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- HY-P3579
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GIP (1-42), porcine
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Insulin Receptor
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Endocrinology
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Gastric Inhibitory Peptide, porcine is a glucose-dependent insulinotropic polypeptide, is a 42 amino acid intestinal hormone with effects on fat and glucose metabolism .
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- HY-P2932
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Cholecystokinin-33(human); CCK-33(human)
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Peptides
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Metabolic Disease
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Cholecystokinin is a peptide hormone. Cholecystokinin, as a hunger suppressant, inhibits food intake and stimulates the digestion of fat and protein. Cholecystokinin can be used for the research of gastrointestinal system .
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- HY-P1067A
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Endogenous Metabolite
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Metabolic Disease
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Enterostatin (human,mouse,rat) TFA is a pentapeptide mainly formed in the intestine by the cleavage of secreted pancreatic procolipase. Enterostatin selectively reduces fat intake, bodyweight, and body fat in vivo .
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- HY-P3704
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Endogenous Metabolite
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Metabolic Disease
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Enterostatin (rat), an orally active activation peptide of procolipase, selectively reduces fat intake. Enterostatin (rat) reduces serum cholesterol levels by way of a CCK1 receptor-dependent mechanism .
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- HY-P1067
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- HY-P3570
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Lom-AKH-II
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Endogenous Metabolite
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Metabolic Disease
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Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs) .
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- HY-P3572
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Lom-AKH-I
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Endogenous Metabolite
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Endocrinology
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Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs) .
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- HY-125357
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Peptides
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Metabolic Disease
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Ternatin (compound 2) is a cyclic heptapeptides that can be isolated from mushroom Coliorus versicolor. Ternatin inhibits fat-accumulation with an IC50 of 0.027 μM in 3T3-L1 adipocytes .
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- HY-P4851
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Manse-AKH
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Peptides
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Others
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Adipokinetic Hormone (Apis mellifera ligustica, Bombyx mori, Heliothis zea, Manduca sexta) is a common peptide among various insects. Adipokinetic Hormone induces strong adipokinetic/hypertrehalosemic response. However Adipokinetic Hormone has no a glycogen-mobilizing function nor an adequate glycogen store in fat body for its effective utilization .
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- HY-P3568
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Grybi-AKH
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Peptides
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Metabolic Disease
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Adipokinetic hormone Gryllus bimaculatus (Grybi-AKH) is an adipokinetic hormone that regulates energy homeostasis in insects by mobilizing lipid and carbohydrate from the fat body. Adipokinetic hormone Gryllus bimaculatus stimulates the locomotor activity of the two-spotted cricket. Adipokinetic hormone Gryllus bimaculatus can also be used in studies to regulate body weight, induce weight loss and alleviate glycogen storage disorders in humans .
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- HY-P2048A
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AMPK
GLUT
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Metabolic Disease
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MOTS-c(human) acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c(human) acetate induces glucose uptake and improves insulin sensitivity. MOTS-c(human) acetate has implications in the regulation of obesity, diabetes, exercise, and longevity .
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- HY-P3578
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Insulin Receptor
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Endocrinology
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Gastric Inhibitory Polypeptide (1-30), porcine lacks the C-terminal 12 amino acid residues of natural gastric inhibitory polypeptide (GIP), exhibits biologic activity by potentiating the release of insulin and somatostatin .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-B1788S
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Taurocholic acid-d4 (sodium) is the deuterium labeled Taurocholic acid. Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.
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- HY-Y0781S
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Pyruvic acid- 13C (sodium) is the 13C-labeled Pyruvic acid. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.
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- HY-Y0781S1
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Pyruvic acid- 13C is the 13C labeled Pyruvic acid[1]. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats[2].
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- HY-Y0781S3
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Pyruvic acid- 13C-2 (sodium) is the 13C labeled Pyruvic acid[1]. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats[2].
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- HY-Y0781S5
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Pyruvic acid- 13C,d4 is the deuterium and 13C labeled Pyruvic acid[1]. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats[2].
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- HY-B1788S1
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Taurocholic acid-d4 is deuterium labeled Taurocholic acid. Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.
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- HY-W753983
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Pyruvic acid-13C is isotype-labeled compound of Pyruvic acid. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats .
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- HY-B0896S1
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Triacetin-d5 is the deuterium labeled Triacetin. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
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- HY-B2219S8
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Stearic acid-d is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-B2219S3
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Stearic acid-d3 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-B2219S1
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Stearic acid-d2 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-B2219S4
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Stearic Acid-d35 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-B2219S6
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Stearic acid-d55 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-B2219S9
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Stearic acid-d7 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-B2219S2
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Stearic acid- 13C18is the 13C-labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-B0896S2
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Glyceryl Triacetate-d9 is the deuterium labeled Triacetin[1]. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
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- HY-N0324S
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Cholic acid-d4 is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
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- HY-N0324S1
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Cholic acid-d5 is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
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- HY-B2219S
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Stearic acid-1- 13C is the 13C labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-N0324S2
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Cholic acid- 13C is the 13C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
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- HY-B2219S7
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Stearic acid-d4 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils[1].
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- HY-N2041S5
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Myristic acid-d is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-N2041S2
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Myristic acid- 13C the 13C is labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-B2219S5
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Stearic acid-9,10-d2 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-N2041S4
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Myristic acid- 13C3 is the 13C labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-N2041S3
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Myristic acid-d33 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-N2041S
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1 Publications Verification
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Myristic acid-d27 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-N2041S1
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Myristic acid-d2 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-N2041S6
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Myristic acid-d5 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-N2041S7
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Myristic acid-d7 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-N2334AS
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Glycochenodeoxycholic acid-d7 (sodium) is the deuterium labeled Glycochenodeoxycholic acid (sodium salt). Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis[1][2].
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- HY-N2334S
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Glycochenodeoxycholic acid-d4 is the deuterium labeled Glycochenodeoxycholic acid. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis[1][2].
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- HY-B0234S1
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Estrone-d2 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
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- HY-B0234S2
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Estrone-d4 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
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- HY-B0234S4
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Estrone-d2-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
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- HY-B0234S
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Estrone- 13C3 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
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- HY-B0234S3
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Estrone- 13C2 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
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- HY-117275S1
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Meclofenamic acid- 13C6 is the 13C6 labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.
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- HY-117275S
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Meclofenamic acid-d4 is the deuterium labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker[1][2][3].
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- HY-W012974S
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3-Amino-2-methylpropanoic acid-d3 is the deuterium labeled 3-Amino-2-methylpropanoic acid[1]. 3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors[2].
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