1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite

3-Amino-2-methylpropanoic acid 

Cat. No.: HY-W012974 Purity: >97.0%
Handling Instructions

3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.

For research use only. We do not sell to patients.

3-Amino-2-methylpropanoic acid Chemical Structure

3-Amino-2-methylpropanoic acid Chemical Structure

CAS No. : 144-90-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Weight is slightly decreased in the mice by the end of 3-Amino-2-methylpropanoic acid (BAIBA) treatment. Analysis of body composition using MRI demonstrates BAIBA treatment significantly decreases body fat in the mice. Consistent with the effects on thermogenic and β-oxidation gene expression and body weights, analysis with metabolic cages indicates that oxygen consumption (VO2) and whole body energy expenditure are increased in the BAIBA treated mice without any significant difference in activity or food intake. The mice are also challenged with an intraperitoneal glucose tolerance test (IPGTT). BAIBA is found to significantly improve the glucose tolerance in the mice as determined by the area under the curve of the IPGTT[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.6974 mL 48.4872 mL 96.9744 mL
5 mM 1.9395 mL 9.6974 mL 19.3949 mL
10 mM 0.9697 mL 4.8487 mL 9.6974 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice[1] Six week old mice are either treated with 3-Amino-2-methylpropanoic acid (BAIBA:100 mg/kg/day) or remains untreated (control mice). Their weights are monitored weekly[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

103.12

Formula

C₄H₉NO₂

CAS No.

144-90-1

SMILES

O=C(O)C(C)CN

Storage

4°C, protect from light

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
3-Amino-2-methylpropanoic acid
Cat. No.:
HY-W012974
Quantity:

3-Amino-2-methylpropanoic acid

Cat. No.: HY-W012974