Cholic acid sodium hydrate
Based on 19 publication(s) in Google Scholar
Cholic acid sodium hydrate is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid sodium hydrate facilitates fat absorption and cholesterol excretion. Cholic acid sodium hydrate is orally active.
For research use only. We do not sell to patients.
- CAS No.: 206986-87-0
- Formula: C24H40O5.xH2O.Na
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Cholic acid sodium hydrate
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Cancer Cell. 2024 Aug 12;42(8):1386-1400.e8. [Abstract]
- Cell Res. 2019 Mar;29(3):193-205. [Abstract]
- Cell Host Microbe. 2025 Aug 19:S1931-3128(25)00291-4. [Abstract]
- Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]
- J Adv Res. 2025 Jul:73:427-442. [Abstract]
- Trends Biotechnol. 2026 Apr 15:S0167-7799(26)00130-7. [Abstract]
- Adv Sci (Weinh). 2025 Mar;12(12):e2411719. [Abstract]
- Research (Wash D C). 2025 Jun 24:8:0741. [Abstract]
- J Transl Med. 2024 Dec 20;22(1):1124. [Abstract]
- Mol Neurobiol. 2024 Nov;61(11):9302-9319. [Abstract]
- J Enzyme Inhib Med Chem. 2025 Dec;40(1):2501743. [Abstract]
- Front Cell Dev Biol. 2022 Jul 22:10:854425. [Abstract]
- Aquaculture. 2023 Sep 18, 740123.
- Microb Pathog. 2026 Jan:210:108187. [Abstract]
- Drug Metab Dispos. 2026 Feb 24.
- J Pharm Biomed Anal. 2025 Jul 15:259:116760. [Abstract]
- J Voice. 2025 Nov 29:S0892-1997(25)00490-4. [Abstract]
- Transl Cancer Res. 2025 Aug 31;14(8):4774-4790. [Abstract]
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In Vivo Efficacy Study
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RT-PCR
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Bio/Physico-chemical Assay
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All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Tg-CYP2D6 adult male mice (8 weeks of age and weighing 20–25 g)[2]
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Dosage:1% (w/w) Cholic acid-supplemented diet
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Administration:Oral, 14 days
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Result:Decreases SHP expression and increased CYP2D6 activity.
Chemical Information
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CAS No. 206986-87-0
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Formula C24H40O5.xH2O.Na
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SMILES
C[C@H](CCC(O[Na])=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C.[xH2O]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (19)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cancer Cell
Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers. [Abstract]2024 Aug 12;42(8):1386-1400.e8. PMID: 39137727 -
Cell Res
Virus-induced accumulation of intracellular bile acids activates the TGR5-β-arrestin-SRC axis to enable innate antiviral immunity. [Abstract]2019 Mar;29(3):193-205. PMID: 30651583 -
Cell Host Microbe
2025 Aug 19:S1931-3128(25)00291-4. PMID: 40848719 -
Cell Host Microbe
A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage. [Abstract]2024 Feb 14;32(2):191-208.e9. PMID: 38237593 -
J Adv Res
Serum taurine affects lung cancer progression by regulating tumor immune escape mediated by the immune microenvironment. [Abstract]2025 Jul:73:427-442. PMID: 39243941
Cholic acid sodium hydrate purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Jul:73:427-442. [Abstract]
The tumor-promoting effects of taurine could be reversed by bile acids (Cholic acid (245.25 mg/kg; p.o.; Once daily)) in C57 mice (n = 6).
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Trends Biotechnol
Engineering Bacillus subtilis as a sustainable platform for the production of functional bile acids. [Abstract]2026 Apr 15:S0167-7799(26)00130-7. PMID: 41991462 -
Adv Sci (Weinh)
Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis. [Abstract]2025 Mar;12(12):e2411719. PMID: 39899681
Cholic acid sodium hydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Mar;12(12):e2411719. [Abstract]
The mRNA levels of ALDOB in Huh7 or HCCLM3 cells treated with various bile acids (100 μM, 24 h). All data are presented as mean ± SD. Data were analyzed by one-way ANOVA with Bonferroni multiple-comparison correction. CA, cholic acid; TCA, taurocholic acid; GCA, glycocholic acid; TCDCA, taurochenodeoxycholic acid; GCDCA, glycochenodeoxycholic acid; LCA, lithocholic acid; TLCA, taurolithocholic acid; GLCA, glycolithocholic acid; DCA, deoxycholic acid; TDCA, taurodeoxycholic acid; GDCA, glycodeoxycholic acid; UDCA, ursodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; GUDCA, glycoursodeoxycholic acid.
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Research (Wash D C)
Single-Cell RNA Transcriptomics and Multi-omics Analyses Reveal the Clinical Effects of Acupuncture on Methadone Reduction. [Abstract]2025 Jun 24:8:0741. PMID: 40556944 -
J Transl Med
Conjugated bile acids alleviate acute pancreatitis through inhibition of TGR5 and NLRP3 mediated inflammation. [Abstract]2024 Dec 20;22(1):1124. PMID: 39707318 -
Mol Neurobiol
Brain Immune Cell Infiltration and Serum Metabolomic Characteristics Reveal that Lauric Acid Promotes Immune Cell Infiltration in Brain and Streptococcus suis Meningitis in Mice. [Abstract]2024 Nov;61(11):9302-9319. PMID: 38625620 -
J Enzyme Inhib Med Chem
Natural product sennoside B disrupts liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein by inhibiting its RNA-binding activity. [Abstract]2025 Dec;40(1):2501743. PMID: 40371698 -
Front Cell Dev Biol
Comprehensive Analysis of Quantitative Proteomics With DIA Mass Spectrometry and ceRNA Network in Intrahepatic Cholestasis of Pregnancy. [Abstract]2022 Jul 22:10:854425. PMID: 35938169
Cholic acid sodium hydrate purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2022 Jul 22:10:854425. [Abstract]
HE results of the placental explant. NC Group: normal placenta; ICP group: normal placenta was stimulated for 48 h with 100 uM Cholic acid.
Cholic acid sodium hydrate purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2022 Jul 22:10:854425. [Abstract]
Western blotting results and gray histogram of the placental explant. NC group: normal placenta; ICP group: the normal placenta was stimulated for 48 h with 100 uM Cholic acid.
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Cholic acid sodium hydrate purchased from MedChemExpress. Usage Cited in: Aquaculture. 2023 Sep 18, 740123.
The results showed that dietary Cholic acid (CA, 100 mg/kg) supplementation increased the levels of T-CHO, LDL-C, and HDL-C (P < 0.05).
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Microb Pathog
Lithocholic acid exerts antiviral activity against porcine epidemic diarrhea virus by enhancing TGR5-mediated type III interferon production. [Abstract]2026 Jan:210:108187. PMID: 41242567 -
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J Pharm Biomed Anal
Integrating 16S rDNA sequencing analysis and targeted metabolomics to explore the mechanism of Xiexin Tang in treating atherosclerosis mice induced by high-fat diet. [Abstract]2025 Jul 15:259:116760. PMID: 40014894 -
J Voice
Deoxycholic Acid Drives ATP4A-Dependent Growth and Migration of Vocal Fold Leukoplakia Epithelial Cells via TGR5/JAK2/STAT3 Signaling. [Abstract]2025 Nov 29:S0892-1997(25)00490-4. PMID: 41320587 -
Transl Cancer Res
Identification of metabolic driver genes and targeted drug screening for lung adenocarcinoma metastasis at the single-cell resolution. [Abstract]2025 Aug 31;14(8):4774-4790. PMID: 40950658
Purity & Documentation
References
[1]. Li Y, et al. Mechanism of hepatic targeting via oral administration of DSPE-PEG-Cholic acid-modified nanoliposomes. Int J Nanomedicine. 2017 Feb 28;12:1673-1684. [Content Brief]
[2]. Pan X, et al. Cholic acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Drug Metab Dispos. 2017 Apr;45(4):346-352. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cholic acid sodium hydrate Related Classifications
HY-N0324B Related Classifications
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