Cat. No.: HY-113016

Elaidic acid

5 Cited Publications

Customer Review

Based on 5 publication(s) in Google Scholar

Elaidic acid is an orally active trans fatty acid. Elaidic acid enhances the stemness of colorectal cancer cells by activating the Wnt/ERK1/2 pathway, thereby promoting cell proliferation, invasion and metastasis, and inhibiting apoptosis. Elaidic acid also inhibits the growth of Lactobacillus and alters the cell surface hydrophobicity of Lactobacillus. Elaidic acid reduces basal 2-deoxyglucose uptake in muscle cells and adipocytes. Elaidic acid can be used in research on colorectal cancer, insulin and other related areas.

For research use only. We do not sell to patients.

Purity: 99.81%
CAS No.: 112-79-8
Formula: C₁₈H₃₄O₂
Molecular Weight:282.46

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Elaidic acid Chemical Structure

CAS No.: 112-79-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (5)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[3]

IL-15

All Wnt Isoforms :

All ERK Isoforms :

All Interleukin Related Isoforms :

In Vitro

Elaidic acid (0-35 μM; 24-48 h) dose-dependently promotes the growth, reduces the apoptosis and enhances the invasive ability of CT26 and HT29 colorectal cancer cells^[1].
Elaidic acid (35 μM; 1 week) enhances the sphere-forming capacity of CT26 colorectal cancer cells under concurrent treatment, pre-treatment, and hypoxic conditions^[1].
Elaidic acid upregulates the expression of stem cell markers (nucleostemin, CD133, Oct4) and dedifferentiation marker (c-Myc), while downregulates the expression of differentiation markers (MUC1, MUC2, CDX2) in CT26 colorectal cancer spheres^[1].
Elaidic acid (0-500 mg/L; 0-24 h) inhibits the growth of L. rhamnosus, L. paracasei, L. zeae, <L. acidophilus and L. plantarum, but exerts no effect on the growth of L. casei^[2].
Elaidic acid (200 mg/L; 0-24 h) reduces the cell surface hydrophobicity of L. paracasei and L. casei^[2].
Elaidic acid (20-500 μM; 24 h) dose-dependently upregulates the mRNA level of TNF-α, decreases the mRNA level of IL-15, and does not enhance insulin-stimulated glucose uptake in differentiated C2C12 myotubes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[3]

Cell Line:

C2C12 myotubes
Concentration:

20, 100, 500 μM
Incubation Time:

24 h
Result:

Reduced the mRNA levels of IL-15.
Did not affect IL-6 levels.
Increased TNF-α mRNA levels.

In Vivo

Elaidic acid (10 mg/mouse; i.p.) promotes the growth and metastasis of CRC tumors in BALB/c mice and upregulates the expression of tumor differentiation markers^[1].
Elaidic acid (0-0.2 mg/kg; i.g.; every 7 days; 4 weeks) increases the number of liver CRC metastatic foci and CD133-positive cells in BALB/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (male, 5 weeks old)^[1]
Dosage:

10 mg/mouse
Administration:

i.p.
Result:

Increased subcutaneous CT26 or HT29 tumor growth.
Enhanced peritoneal metastasis size of CT26 or HT29 cells.
Enhanced liver metastasis of CT26 or HT29 cells.
Enhanced lung metastasis of CT26 or HT29 cells.
Increased expression of differentiation markers MUC1, MUC2, and CDX2.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 112-79-8
Appearance Solid
Molecular Weight 282.46
Formula C₁₈H₃₄O₂
Color White to off-white
SMILES

CCCCCCCC/C=C/CCCCCCCC(O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (5)

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
J Exp Clin Cancer Res

DHRS2 mediates cell growth inhibition induced by Trichothecin in nasopharyngeal carcinoma. [Abstract]

2019 Jul 10;38(1):300. PMID: 31291971
Cell Rep Med

High-fat diet increases circulating palmitic acid produced by gut Bacteroides thetaiotaomicron to promote thrombosis. [Abstract]

2025 Aug 19;6(8):102260. PMID: 40749683
Cancer Lett

Targeting C/EBPβ/SCD1/C16:1 loop-driven macrophage M2 polarization by Bruceine D improves anti-PD-1 immunotherapy in colorectal cancer. [Abstract]

2026 Sep 28:656:218655. PMID: 42250753
Oncogene

ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation. [Abstract]

2025 Sep;44(34):3096-3112. PMID: 40595416

Solvent & Solubility

In Vitro:

Ethanol : ≥ 100 mg/mL (354.03 mM)

DMSO : 13.5 mg/mL (47.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5403 mL

17.7016 mL

35.4032 mL

5 mM

0.7081 mL

3.5403 mL

7.0806 mL

10 mM

0.3540 mL

1.7702 mL

3.5403 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.35 mg/mL (4.78 mM); Clear solution

This protocol yields a clear solution of ≥ 1.35 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (13.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ohmori H, et al. Elaidic Acid, a Trans-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells. Pathobiology. 2017;84(3):144-151. [Content Brief]

[2]. Wu Q, et al. Effects of elaidic acid, a predominant industrial trans fatty acid, on bacterial growth and cell surface hydrophobicity of lactobacilli. J Food Sci. 2014;79(12):M2485-M2490. [Content Brief]

[3]. Granados N, et al. Distinct effects of oleic acid and its trans-isomer elaidic acid on the expression of myokines and adipokines in cell models. Br J Nutr. 2011;105(8):1226-1234. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / Ethanol	1 mM	3.5403 mL	17.7016 mL	35.4032 mL	88.5081 mL
	5 mM	0.7081 mL	3.5403 mL	7.0806 mL	17.7016 mL
	10 mM	0.3540 mL	1.7702 mL	3.5403 mL	8.8508 mL
	15 mM	0.2360 mL	1.1801 mL	2.3602 mL	5.9005 mL
	20 mM	0.1770 mL	0.8851 mL	1.7702 mL	4.4254 mL
	25 mM	0.1416 mL	0.7081 mL	1.4161 mL	3.5403 mL
	30 mM	0.1180 mL	0.5901 mL	1.1801 mL	2.9503 mL
	40 mM	0.0885 mL	0.4425 mL	0.8851 mL	2.2127 mL
Ethanol	50 mM	0.0708 mL	0.3540 mL	0.7081 mL	1.7702 mL
	60 mM	0.0590 mL	0.2950 mL	0.5901 mL	1.4751 mL
	80 mM	0.0443 mL	0.2213 mL	0.4425 mL	1.1064 mL
	100 mM	0.0354 mL	0.1770 mL	0.3540 mL	0.8851 mL

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Elaidic acid

Anti-Infection Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

MAPK Compound Library

Stem Cell Signaling Compound Library

Wnt/Hedgehog/Notch Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Lipid Compound Library

Oxygen Sensing Compound Library

Antibacterial Compound Library

Medicine Food Homology Compound Library

Cytoskeleton Compound Library

Orally Active Compound Library

Glutamine Metabolism Compound Library

Traditional Chinese Medicine Active Compound Library

Neuroprotective Compound Library

Anti-Breast Cancer Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Food-Sourced Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Cancer Natural Product Library

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MCE Bioactive Compound Library

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Bioactive Compound Library

Fatty Acids Compound Library

Miao Ethnicity Medicine Compound Library

Tibetan Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

Flavor Compound Library

High-Throughput Bioactive Compound Library

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Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Chinese Baijiu Compound Library

Natural Product Diversity Scaffold Library

Tonifying Traditional Chinese Medicine Monomer Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Elaidic acid

All Wnt Isoforms

All ERK Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Publications (5)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Elaidic acid Related Classifications

HY-113016 Related Classifications