2. Apoptosis Stem Cell/Wnt MAPK/ERK Pathway Anti-infection Immunology/Inflammation
  3. Apoptosis Wnt ERK Bacterial Interleukin Related
  4. Elaidic acid

Elaidic acid is an orally active trans fatty acid. Elaidic acid enhances the stemness of colorectal cancer cells by activating the Wnt/ERK1/2 pathway, thereby promoting cell proliferation, invasion and metastasis, and inhibiting apoptosis. Elaidic acid also inhibits the growth of Lactobacillus and alters the cell surface hydrophobicity of Lactobacillus. Elaidic acid reduces basal 2-deoxyglucose uptake in muscle cells and adipocytes. Elaidic acid can be used in research on colorectal cancer, insulin and other related areas.

For research use only. We do not sell to patients.

Elaidic acid

Elaidic acid Chemical Structure

CAS No. : 112-79-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Elaidic acid:

Elaidic acid Related Antibodies

Top Publications Citing Use of Products

View All Wnt Isoform Specific Products:

View All Isoforms
Wnt1 Wnt3 Wnt5 Wnt7 Wnt11

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Elaidic acid is an orally active trans fatty acid. Elaidic acid enhances the stemness of colorectal cancer cells by activating the Wnt/ERK1/2 pathway, thereby promoting cell proliferation, invasion and metastasis, and inhibiting apoptosis. Elaidic acid also inhibits the growth of Lactobacillus and alters the cell surface hydrophobicity of Lactobacillus. Elaidic acid reduces basal 2-deoxyglucose uptake in muscle cells and adipocytes. Elaidic acid can be used in research on colorectal cancer, insulin and other related areas[1][2][3].

IC50 & Target[3]

IL-15

 

In Vitro

Elaidic acid (0-35 μM; 24-48 h) dose-dependently promotes the growth, reduces the apoptosis and enhances the invasive ability of CT26 and HT29 colorectal cancer cells[1].
Elaidic acid (35 μM; 1 week) enhances the sphere-forming capacity of CT26 colorectal cancer cells under concurrent treatment, pre-treatment, and hypoxic conditions[1].
Elaidic acid upregulates the expression of stem cell markers (nucleostemin, CD133, Oct4) and dedifferentiation marker (c-Myc), while downregulates the expression of differentiation markers (MUC1, MUC2, CDX2) in CT26 colorectal cancer spheres[1].
Elaidic acid (0-500 mg/L; 0-24 h) inhibits the growth of L. rhamnosus, L. paracasei, L. zeae, <L. acidophilus and L. plantarum, but exerts no effect on the growth of L. casei[2].
Elaidic acid (200 mg/L; 0-24 h) reduces the cell surface hydrophobicity of L. paracasei and L. casei[2].
Elaidic acid (20-500 μM; 24 h) dose-dependently upregulates the mRNA level of TNF-α, decreases the mRNA level of IL-15, and does not enhance insulin-stimulated glucose uptake in differentiated C2C12 myotubes[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Elaidic acid Related Antibodies

RT-PCR[3]

Cell Line: C2C12 myotubes
Concentration: 20, 100, 500 μM
Incubation Time: 24 h
Result: Reduced the mRNA levels of IL-15.
Did not affect IL-6 levels.
Increased TNF-α mRNA levels.
In Vivo

Elaidic acid (10 mg/mouse; i.p.) promotes the growth and metastasis of CRC tumors in BALB/c mice and upregulates the expression of tumor differentiation markers[1].
Elaidic acid (0-0.2 mg/kg; i.g.; every 7 days; 4 weeks) increases the number of liver CRC metastatic foci and CD133-positive cells in BALB/c mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (male, 5 weeks old)[1]
Dosage: 10 mg/mouse
Administration: i.p.
Result: Increased subcutaneous CT26 or HT29 tumor growth.
Enhanced peritoneal metastasis size of CT26 or HT29 cells.
Enhanced liver metastasis of CT26 or HT29 cells.
Enhanced lung metastasis of CT26 or HT29 cells.
Increased expression of differentiation markers MUC1, MUC2, and CDX2.
Clinical Trial
Molecular Weight

282.46

Formula

C18H34O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCC/C=C/CCCCCCCC(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

Ethanol : ≥ 100 mg/mL (354.03 mM)

DMSO : 13.5 mg/mL (47.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5403 mL 17.7016 mL 35.4032 mL
5 mM 0.7081 mL 3.5403 mL 7.0806 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 1.35 mg/mL (4.78 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.35 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (13.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.81%

SDS (392 KB)

COA (237 KB) HNMR (160 KB) RP-HPLC (209 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 3.5403 mL 17.7016 mL 35.4032 mL 88.5081 mL
5 mM 0.7081 mL 3.5403 mL 7.0806 mL 17.7016 mL
10 mM 0.3540 mL 1.7702 mL 3.5403 mL 8.8508 mL
15 mM 0.2360 mL 1.1801 mL 2.3602 mL 5.9005 mL
20 mM 0.1770 mL 0.8851 mL 1.7702 mL 4.4254 mL
25 mM 0.1416 mL 0.7081 mL 1.4161 mL 3.5403 mL
30 mM 0.1180 mL 0.5901 mL 1.1801 mL 2.9503 mL
40 mM 0.0885 mL 0.4425 mL 0.8851 mL 2.2127 mL
Ethanol 50 mM 0.0708 mL 0.3540 mL 0.7081 mL 1.7702 mL
60 mM 0.0590 mL 0.2950 mL 0.5901 mL 1.4751 mL
80 mM 0.0443 mL 0.2213 mL 0.4425 mL 1.1064 mL
100 mM 0.0354 mL 0.1770 mL 0.3540 mL 0.8851 mL
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Elaidic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elaidic acid112-79-8ApoptosisWntERKBacterialInterleukin RelatedExtracellular signal regulated kinasesILERK1/2HT29 colorectal cancer cellsIL-15C2C12 myotubesTNF-αcolorectal cancerCT26 colorectal cancer cellsinsulin resistanceInhibitorinhibitorinhibit

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