Adipokinetic hormone I (Locusta migratoria)
Based on 1 Customer Validation
Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs).
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 61627-67-6
- Formula: C54H74N14O15
- Molecular Weight:1159.25
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Adipokinetic hormone I (Locusta migratoria) (radiolabeled; 1 pmol in 10 μL of 10% methanol; 30 min on ice, and repeated for 2 h at 30 °C) shows no association with one of the larger protein components, indicating a lack of separate transporting or carrier protein in the hemolymph[1].
Adipokinetic hormones (AKHs) are known to be involved in insect immunity and shows the mechanism of metabolic stimulation, leading a significant increase in carbon dioxide production, and efficacy increase of toxins produced by I. fumosorosea in the cockroach's body[2].
Adipokinetic hormone II is more effective than hormone I in bringing about an accumulation of cAMP in the fat body[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 61627-67-6
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Appearance Solid
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Molecular Weight 1159.25
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Formula C54H74N14O15
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Color White to off-white
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Synonyms
Lom-AKH-I
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Sequence Shortening
{Glp}-LNFTPNWGT-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (86.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (287 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Oudejans RC, et al. Locust adipokinetic hormones: carrier-independent transport and differential inactivation at physiological concentrations during rest and flight. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8654-9. [Content Brief]
[2]. Gautam UK, et al. Adipokinetic hormone promotes infection with entomopathogenic fungus Isaria fumosorosea in the cockroach Periplaneta americana. Comp Biochem Physiol C Toxicol Pharmacol. 2020 Mar;229:108677. [Content Brief]
[3]. Vroemen SF, et al. Stimulation of glycogenolysis by three locust adipokinetic hormones involves Gs and cAMP. Mol Cell Endocrinol. 1995 Feb;107(2):165-71. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8626 mL | 4.3131 mL | 8.6263 mL | 21.5657 mL |
| 5 mM | 0.1725 mL | 0.8626 mL | 1.7253 mL | 4.3131 mL | |
| 10 mM | 0.0863 mL | 0.4313 mL | 0.8626 mL | 2.1566 mL | |
| 15 mM | 0.0575 mL | 0.2875 mL | 0.5751 mL | 1.4377 mL | |
| 20 mM | 0.0431 mL | 0.2157 mL | 0.4313 mL | 1.0783 mL | |
| 25 mM | 0.0345 mL | 0.1725 mL | 0.3451 mL | 0.8626 mL | |
| 30 mM | 0.0288 mL | 0.1438 mL | 0.2875 mL | 0.7189 mL | |
| 40 mM | 0.0216 mL | 0.1078 mL | 0.2157 mL | 0.5391 mL | |
| 50 mM | 0.0173 mL | 0.0863 mL | 0.1725 mL | 0.4313 mL | |
| 60 mM | 0.0144 mL | 0.0719 mL | 0.1438 mL | 0.3594 mL | |
| 80 mM | 0.0108 mL | 0.0539 mL | 0.1078 mL | 0.2696 mL |
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