61627-67-6
Chemical Structure
Adipokinetic hormone I (Locusta migratoria)
Synonym(s): Lom-AKH-I
- CAS No.: 61627-67-6
- Formula:C54H74N14O15
- Molecular Weight:1159.25
InChIKey: CBCYLWRKHYMJDA-KGFCHOLISA-N
SMILES: O=C([C@H]1N(CCC1)C([C@H]([C@H](O)C)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@@H]2CCC(N2)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)N[C@@H](CC(N)=O)C(N[C@H](C(NCC(N[C@H](C(N)=O)[C@H](O)C)=O)=O)CC4=CNC5=CC=CC=C45)=O
Biological Activity: Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs)[1][3].
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Adipokinetic hormone I (Locusta migratoria) | 99.88% | Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs). | ||||||||||||||||||||
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References
- [1]. Oudejans RC, et al. Locust adipokinetic hormones: carrier-independent transport and differential inactivation at physiological concentrations during rest and flight. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8654-9. [Content Brief]
- [3]. Vroemen SF, et al. Stimulation of glycogenolysis by three locust adipokinetic hormones involves Gs and cAMP. Mol Cell Endocrinol. 1995 Feb;107(2):165-71. [Content Brief]
