2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Cholic acid sodium

Cholic acid sodium  (Synonyms: Sodium cholate)

Cat. No.: HY-N0324A Purity: 99.85%
COA
SDS
Handling Instructions Technical Support

Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid sodium is orally active.

For research use only. We do not sell to patients.

CAS No. : 361-09-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
1 g In-stock
10 g In-stock
25 g In-stock
50 g In-stock
> 100 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 20 publication(s) in Google Scholar

Other Forms of Cholic acid sodium:

Cholic acid sodium Related Antibodies

Top Publications Citing Use of Products

    Cholic acid sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Feb 3:e2411719.  [Abstract]

    The mRNA levels of ALDOB in Huh7 or HCCLM3 cells treated with various bile acids (100 μM, 24 h). All data are presented as mean ± SD. Data were analyzed by one-way ANOVA with Bonferroni multiple-comparison correction. CA, cholic acid; TCA, taurocholic acid; GCA, glycocholic acid; TCDCA, taurochenodeoxycholic acid; GCDCA, glycochenodeoxycholic acid; LCA, lithocholic acid; TLCA, taurolithocholic acid; GLCA, glycolithocholic acid; DCA, deoxycholic acid; TDCA, taurodeoxycholic acid; GDCA, glycodeoxycholic acid; UDCA, ursodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; GUDCA, glycoursodeoxycholic acid.

    Cholic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Sep 5:S2090-1232(24)00389-8.  [Abstract]

    The tumor-promoting effects of taurine could be reversed by bile acids (Cholic acid (245.25 mg/kg; p.o.; Once daily)) in C57 mice (n = 6).

    Cholic acid sodium purchased from MedChemExpress. Usage Cited in: Aquaculture. 2023 Sep 18, 740123.

    The results showed that dietary Cholic acid (CA, 100 mg/kg) supplementation increased the levels of T-CHO, LDL-C, and HDL-C (P < 0.05).

    Cholic acid sodium purchased from MedChemExpress. Usage Cited in: Aquaculture. 2023 Sep 18, 740123.

    Cholic acid (CA, 100 mg/kg; dietary administration) significantly increased the mRNA expression levels of IL-6, IL-8, IL-1β, and iNOS in grass carp.

    Cholic acid sodium purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2022 Jul 22:10:854425.

    HE results of the placental explant. NC Group: normal placenta; ICP group: normal placenta was stimulated for 48 h with 100 uM Cholic acid.

    Cholic acid sodium purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2022 Jul 22:10:854425.

    Western blotting results and gray histogram of the placental explant. NC group: normal placenta; ICP group: the normal placenta was stimulated for 48 h with 100 uM Cholic acid.

    View All Endogenous Metabolite Isoform Specific Products:

    View All Isoforms
    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid sodium is orally active[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cholic acid sodium Related Antibodies
    In Vivo

    Cholic acid? (1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Tg-CYP2D6 adult male mice (8 weeks of age and weighing 20–25 g)[2]
    Dosage: 1% (w/w) Cholic acid-supplemented diet
    Administration: Oral, 14 days
    Result: Decreases SHP expression and increased CYP2D6 activity.
    Molecular Weight

    430.55

    Formula

    C24H39NaO5
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    C[C@H](CCC(O[Na])=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 116.67 mg/mL (270.98 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3226 mL 11.6131 mL 23.2261 mL
    5 mM 0.4645 mL 2.3226 mL 4.6452 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (232.26 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.85%

    SDS (393 KB)

    COA (252 KB) HNMR (282 KB) RP-HPLC (244 KB) MS (72 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.3226 mL 11.6131 mL 23.2261 mL 58.0653 mL
    5 mM 0.4645 mL 2.3226 mL 4.6452 mL 11.6131 mL
    10 mM 0.2323 mL 1.1613 mL 2.3226 mL 5.8065 mL
    15 mM 0.1548 mL 0.7742 mL 1.5484 mL 3.8710 mL
    20 mM 0.1161 mL 0.5807 mL 1.1613 mL 2.9033 mL
    25 mM 0.0929 mL 0.4645 mL 0.9290 mL 2.3226 mL
    30 mM 0.0774 mL 0.3871 mL 0.7742 mL 1.9355 mL
    40 mM 0.0581 mL 0.2903 mL 0.5807 mL 1.4516 mL
    50 mM 0.0465 mL 0.2323 mL 0.4645 mL 1.1613 mL
    60 mM 0.0387 mL 0.1936 mL 0.3871 mL 0.9678 mL
    80 mM 0.0290 mL 0.1452 mL 0.2903 mL 0.7258 mL
    100 mM 0.0232 mL 0.1161 mL 0.2323 mL 0.5807 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Cholic acid sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Cholic acid361-09-1Sodium cholateEndogenous Metaboliteglycinetaurinecholesterol excretionHepG2Inhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Cholic acid sodium
    Cat. No.:
    HY-N0324A
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.