Art. -Nr.: HY-N0324A

Cholic acid sodium

(Synonyms: Sodium cholate)

21 Cited Publications

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Based on 21 publication(s) in Google Scholar

Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid sodium is orally active.

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Reinheit: 99.85%
CAS. Nr.: 361-09-1
Formel: C₂₄H₃₉NaO₅
Molecular Weight:430.55

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Cholic acid sodium Chemical Structure

CAS. Nr.: 361-09-1

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (21)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

Cholic acid (1 mg/mL, 30 min) competitively binds Na⁺/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cholic acid? (1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Tg-CYP2D6 adult male mice (8 weeks of age and weighing 20–25 g)^[2]
Dosage:

1% (w/w) Cholic acid-supplemented diet
Administration:

Oral, 14 days
Result:

Decreases SHP expression and increased CYP2D6 activity.

Chemical Information

CAS. Nr. 361-09-1
Appearance Solid
Molecular Weight 430.55
Formel C₂₄H₃₉NaO₅
Color White to off-white
SMILES

C[C@H](CCC(O[Na])=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C
Synonyms

Sodium cholate
Structure Classification
- Steroids
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (21)

All In Vivo Efficacy StudyHistological Imaging/StainingBio/Physico-chemical AssayWBRT-PCR

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Journal Impact Factor

Cancer Cell

Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers. [Abstract]

2024 Aug 12;42(8):1386-1400.e8. PMID: 39137727
Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Cell Res

Virus-induced accumulation of intracellular bile acids activates the TGR5-β-arrestin-SRC axis to enable innate antiviral immunity. [Abstract]

2019 Mar;29(3):193-205. PMID: 30651583
Adv Mater

Light-Driven Artificial Cell Micromotors for Degenerative Knee Osteoarthritis. [Abstract]

2025 Apr;37(17):e2416349. PMID: 40025988
Cell Host Microbe

Veillonella intestinal colonization promotes C. difficile infection in Crohn's disease. [Abstract]

2025 Aug 19:S1931-3128(25)00291-4. PMID: 40848719
Cell Host Microbe

A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage. [Abstract]

2024 Feb 14;32(2):191-208.e9. PMID: 38237593
J Adv Res

Serum taurine affects lung cancer progression by regulating tumor immune escape mediated by the immune microenvironment. [Abstract]

2024 Sep 5:S2090-1232(24)00389-8. PMID: 39243941

Cholic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Sep 5:S2090-1232(24)00389-8. [Abstract]

The tumor-promoting effects of taurine could be reversed by bile acids (Cholic acid (245.25 mg/kg; p.o.; Once daily)) in C57 mice (n = 6).
Trends Biotechnol

Engineering Bacillus subtilis as a sustainable platform for the production of functional bile acids. [Abstract]

2026 Apr 15:S0167-7799(26)00130-7. PMID: 41991462
Adv Sci (Weinh)

Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis. [Abstract]

2025 Feb 3:e2411719. PMID: 39899681

Cholic acid sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Feb 3:e2411719. [Abstract]

The mRNA levels of ALDOB in Huh7 or HCCLM3 cells treated with various bile acids (100 μM, 24 h). All data are presented as mean ± SD. Data were analyzed by one-way ANOVA with Bonferroni multiple-comparison correction. CA, cholic acid; TCA, taurocholic acid; GCA, glycocholic acid; TCDCA, taurochenodeoxycholic acid; GCDCA, glycochenodeoxycholic acid; LCA, lithocholic acid; TLCA, taurolithocholic acid; GLCA, glycolithocholic acid; DCA, deoxycholic acid; TDCA, taurodeoxycholic acid; GDCA, glycodeoxycholic acid; UDCA, ursodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; GUDCA, glycoursodeoxycholic acid.
Research (Wash D C)

Single-Cell RNA Transcriptomics and Multi-omics Analyses Reveal the Clinical Effects of Acupuncture on Methadone Reduction. [Abstract]

2025 Jun 24:8:0741. PMID: 40556944
J Transl Med

Conjugated bile acids alleviate acute pancreatitis through inhibition of TGR5 and NLRP3 mediated inflammation. [Abstract]

2024 Dec 20;22(1):1124. PMID: 39707318
Cell Rep

Multilevel regulation of c-di-GMP biosynthesis by cAMP signaling increases Shigella sonnei fitness and pathogenicity in response to bile salts. [Abstract]

2025 Sep 17;44(10):116306. PMID: 40966079
Mol Neurobiol

Brain Immune Cell Infiltration and Serum Metabolomic Characteristics Reveal that Lauric Acid Promotes Immune Cell Infiltration in Brain and Streptococcus suis Meningitis in Mice. [Abstract]

2024 Nov;61(11):9302-9319. PMID: 38625620
J Enzyme Inhib Med Chem

Natural product sennoside B disrupts liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein by inhibiting its RNA-binding activity. [Abstract]

2025 Dec;40(1):2501743. PMID: 40371698
Front Cell Dev Biol

Comprehensive Analysis of Quantitative Proteomics With DIA Mass Spectrometry and ceRNA Network in Intrahepatic Cholestasis of Pregnancy. [Abstract]

2022 Jul 22:10:854425. PMID: 35938169

Cholic acid sodium purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2022 Jul 22:10:854425. [Abstract]

HE results of the placental explant. NC Group: normal placenta; ICP group: normal placenta was stimulated for 48 h with 100 uM Cholic acid.

Cholic acid sodium purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2022 Jul 22:10:854425. [Abstract]

Western blotting results and gray histogram of the placental explant. NC group: normal placenta; ICP group: the normal placenta was stimulated for 48 h with 100 uM Cholic acid.
Aquaculture

2023 Sep 18, 740123.

Cholic acid sodium purchased from MedChemExpress. Usage Cited in: Aquaculture. 2023 Sep 18, 740123.

The results showed that dietary Cholic acid (CA, 100 mg/kg) supplementation increased the levels of T-CHO, LDL-C, and HDL-C (P < 0.05).

Cholic acid sodium purchased from MedChemExpress. Usage Cited in: Aquaculture. 2023 Sep 18, 740123.

Cholic acid (CA, 100 mg/kg; dietary administration) significantly increased the mRNA expression levels of IL-6, IL-8, IL-1β, and iNOS in grass carp.
Microb Pathog

Lithocholic acid exerts antiviral activity against porcine epidemic diarrhea virus by enhancing TGR5-mediated type III interferon production. [Abstract]

2026 Jan:210:108187. PMID: 41242567
Drug Metab Dispos

2026 Feb 24.
J Pharm Biomed Anal

Integrating 16S rDNA sequencing analysis and targeted metabolomics to explore the mechanism of Xiexin Tang in treating atherosclerosis mice induced by high-fat diet. [Abstract]

2025 Jul 15:259:116760. PMID: 40014894
J Voice

Deoxycholic Acid Drives ATP4A-Dependent Growth and Migration of Vocal Fold Leukoplakia Epithelial Cells via TGR5/JAK2/STAT3 Signaling. [Abstract]

2025 Nov 29:S0892-1997(25)00490-4. PMID: 41320587
Transl Cancer Res

Identification of metabolic driver genes and targeted drug screening for lung adenocarcinoma metastasis at the single-cell resolution. [Abstract]

2025 Aug 31;14(8):4774-4790. PMID: 40950658

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 116.67 mg/mL (270.98 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3226 mL

11.6131 mL

23.2261 mL

5 mM

0.4645 mL

2.3226 mL

4.6452 mL

10 mM

0.2323 mL

1.1613 mL

2.3226 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (232.26 mM); Clear solution; Need ultrasonic

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li Y, et al. Mechanism of hepatic targeting via oral administration of DSPE-PEG-Cholic acid-modified nanoliposomes. Int J Nanomedicine. 2017 Feb 28;12:1673-1684. [Content Brief]

[2]. Pan X, et al. Cholic acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Drug Metab Dispos. 2017 Apr;45(4):346-352. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	2.3226 mL	11.6131 mL	23.2261 mL	58.0653 mL
	5 mM	0.4645 mL	2.3226 mL	4.6452 mL	11.6131 mL
	10 mM	0.2323 mL	1.1613 mL	2.3226 mL	5.8065 mL
	15 mM	0.1548 mL	0.7742 mL	1.5484 mL	3.8710 mL
	20 mM	0.1161 mL	0.5807 mL	1.1613 mL	2.9033 mL
	25 mM	0.0929 mL	0.4645 mL	0.9290 mL	2.3226 mL
	30 mM	0.0774 mL	0.3871 mL	0.7742 mL	1.9355 mL
	40 mM	0.0581 mL	0.2903 mL	0.5807 mL	1.4516 mL
	50 mM	0.0465 mL	0.2323 mL	0.4645 mL	1.1613 mL
	60 mM	0.0387 mL	0.1936 mL	0.3871 mL	0.9678 mL
	80 mM	0.0290 mL	0.1452 mL	0.2903 mL	0.7258 mL
	100 mM	0.0232 mL	0.1161 mL	0.2323 mL	0.5807 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Cholic acid sodium

21 Cited Publications

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Cholic acid sodium

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Publications Citing Use of MedChemExpress (MCE) Cholic acid sodium

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (21)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Cholic acid sodium Related Classifications

HY-N0324A Related Classifications