Cholic acid sodium
Based on 21 publication(s) in Google Scholar
Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid sodium is orally active.
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 361-09-1
- Formula: C24H39NaO5
- Molecular Weight:430.55
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-N0593A
Deoxycholic acid sodium salt
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HY-B0172
Lithocholic acid
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HY-N0324
Cholic acid
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HY-N0545
Taurocholic acid sodium
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HY-76847
Chenodeoxycholic Acid
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HY-19696A
Tauroursodeoxycholate sodium
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HY-128974
N-Dodecyl-β-D-maltoside
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HY-N2334A
Glycochenodeoxycholic acid sodium salt
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HY-15435
CHAPS
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HY-76847A
Chenodeoxycholic acid sodium
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HY-13771
Ursodeoxycholic acid
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HY-N0593
Deoxycholic acid
Publications Citing Use of MedChemExpress (MCE) Cholic acid sodium
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Cancer Cell. 2024 Aug 12;42(8):1386-1400.e8. [Abstract]
- Cell Res. 2019 Mar;29(3):193-205. [Abstract]
- Adv Mater. 2025 Apr;37(17):e2416349. [Abstract]
- Cell Host Microbe. 2025 Aug 19:S1931-3128(25)00291-4. [Abstract]
- Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]
- J Adv Res. 2025 Jul:73:427-442. [Abstract]
- Trends Biotechnol. 2026 Apr 15:S0167-7799(26)00130-7. [Abstract]
- Adv Sci (Weinh). 2025 Mar;12(12):e2411719. [Abstract]
- Research (Wash D C). 2025 Jun 24:8:0741. [Abstract]
- J Transl Med. 2024 Dec 20;22(1):1124. [Abstract]
- Cell Rep. 2025 Sep 17;44(10):116306. [Abstract]
- Mol Neurobiol. 2024 Nov;61(11):9302-9319. [Abstract]
- J Enzyme Inhib Med Chem. 2025 Dec;40(1):2501743. [Abstract]
- Front Cell Dev Biol. 2022 Jul 22:10:854425. [Abstract]
- Aquaculture. 2023 Sep 18, 740123.
- Microb Pathog. 2026 Jan:210:108187. [Abstract]
- Drug Metab Dispos. 2026 Feb 24.
- J Pharm Biomed Anal. 2025 Jul 15:259:116760. [Abstract]
- J Voice. 2025 Nov 29:S0892-1997(25)00490-4. [Abstract]
- Transl Cancer Res. 2025 Aug 31;14(8):4774-4790. [Abstract]
Customer Validation & Images
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In Vivo Efficacy Study
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RT-PCR
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Bio/Physico-chemical Assay
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RT-PCR
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Histological Imaging/Staining
All Endogenous Metabolite Isoforms
More
Biological Activity
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Human Endogenous Metabolite |
Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Tg-CYP2D6 adult male mice (8 weeks of age and weighing 20–25 g)[2]
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Dosage:1% (w/w) Cholic acid-supplemented diet
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Administration:Oral, 14 days
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Result:Decreases SHP expression and increased CYP2D6 activity.
Chemical Information
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CAS No. 361-09-1
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Appearance Solid
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Molecular Weight 430.55
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Formula C24H39NaO5
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Color White to off-white
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SMILES
C[C@H](CCC(O[Na])=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C
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Synonyms
Sodium cholate
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (21)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cancer Cell
Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers. [Abstract]2024 Aug 12;42(8):1386-1400.e8. PMID: 39137727 -
Cell Res
Virus-induced accumulation of intracellular bile acids activates the TGR5-β-arrestin-SRC axis to enable innate antiviral immunity. [Abstract]2019 Mar;29(3):193-205. PMID: 30651583 -
Adv Mater
2025 Apr;37(17):e2416349. PMID: 40025988 -
Cell Host Microbe
2025 Aug 19:S1931-3128(25)00291-4. PMID: 40848719 -
Cell Host Microbe
A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage. [Abstract]2024 Feb 14;32(2):191-208.e9. PMID: 38237593 -
J Adv Res
Serum taurine affects lung cancer progression by regulating tumor immune escape mediated by the immune microenvironment. [Abstract]2025 Jul:73:427-442. PMID: 39243941
Cholic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Jul:73:427-442. [Abstract]
The tumor-promoting effects of taurine could be reversed by bile acids (Cholic acid (245.25 mg/kg; p.o.; Once daily)) in C57 mice (n = 6).
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Trends Biotechnol
Engineering Bacillus subtilis as a sustainable platform for the production of functional bile acids. [Abstract]2026 Apr 15:S0167-7799(26)00130-7. PMID: 41991462 -
Adv Sci (Weinh)
Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis. [Abstract]2025 Mar;12(12):e2411719. PMID: 39899681
Cholic acid sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Mar;12(12):e2411719. [Abstract]
The mRNA levels of ALDOB in Huh7 or HCCLM3 cells treated with various bile acids (100 μM, 24 h). All data are presented as mean ± SD. Data were analyzed by one-way ANOVA with Bonferroni multiple-comparison correction. CA, cholic acid; TCA, taurocholic acid; GCA, glycocholic acid; TCDCA, taurochenodeoxycholic acid; GCDCA, glycochenodeoxycholic acid; LCA, lithocholic acid; TLCA, taurolithocholic acid; GLCA, glycolithocholic acid; DCA, deoxycholic acid; TDCA, taurodeoxycholic acid; GDCA, glycodeoxycholic acid; UDCA, ursodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; GUDCA, glycoursodeoxycholic acid.
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Research (Wash D C)
Single-Cell RNA Transcriptomics and Multi-omics Analyses Reveal the Clinical Effects of Acupuncture on Methadone Reduction. [Abstract]2025 Jun 24:8:0741. PMID: 40556944 -
J Transl Med
Conjugated bile acids alleviate acute pancreatitis through inhibition of TGR5 and NLRP3 mediated inflammation. [Abstract]2024 Dec 20;22(1):1124. PMID: 39707318 -
Cell Rep
Multilevel regulation of c-di-GMP biosynthesis by cAMP signaling increases Shigella sonnei fitness and pathogenicity in response to bile salts. [Abstract]2025 Sep 17;44(10):116306. PMID: 40966079 -
Mol Neurobiol
Brain Immune Cell Infiltration and Serum Metabolomic Characteristics Reveal that Lauric Acid Promotes Immune Cell Infiltration in Brain and Streptococcus suis Meningitis in Mice. [Abstract]2024 Nov;61(11):9302-9319. PMID: 38625620 -
J Enzyme Inhib Med Chem
Natural product sennoside B disrupts liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein by inhibiting its RNA-binding activity. [Abstract]2025 Dec;40(1):2501743. PMID: 40371698 -
Front Cell Dev Biol
Comprehensive Analysis of Quantitative Proteomics With DIA Mass Spectrometry and ceRNA Network in Intrahepatic Cholestasis of Pregnancy. [Abstract]2022 Jul 22:10:854425. PMID: 35938169
Cholic acid sodium purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2022 Jul 22:10:854425. [Abstract]
HE results of the placental explant. NC Group: normal placenta; ICP group: normal placenta was stimulated for 48 h with 100 uM Cholic acid.
Cholic acid sodium purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2022 Jul 22:10:854425. [Abstract]
Western blotting results and gray histogram of the placental explant. NC group: normal placenta; ICP group: the normal placenta was stimulated for 48 h with 100 uM Cholic acid.
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Cholic acid sodium purchased from MedChemExpress. Usage Cited in: Aquaculture. 2023 Sep 18, 740123.
The results showed that dietary Cholic acid (CA, 100 mg/kg) supplementation increased the levels of T-CHO, LDL-C, and HDL-C (P < 0.05).
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Microb Pathog
Lithocholic acid exerts antiviral activity against porcine epidemic diarrhea virus by enhancing TGR5-mediated type III interferon production. [Abstract]2026 Jan:210:108187. PMID: 41242567 -
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J Pharm Biomed Anal
Integrating 16S rDNA sequencing analysis and targeted metabolomics to explore the mechanism of Xiexin Tang in treating atherosclerosis mice induced by high-fat diet. [Abstract]2025 Jul 15:259:116760. PMID: 40014894 -
J Voice
Deoxycholic Acid Drives ATP4A-Dependent Growth and Migration of Vocal Fold Leukoplakia Epithelial Cells via TGR5/JAK2/STAT3 Signaling. [Abstract]2025 Nov 29:S0892-1997(25)00490-4. PMID: 41320587 -
Transl Cancer Res
Identification of metabolic driver genes and targeted drug screening for lung adenocarcinoma metastasis at the single-cell resolution. [Abstract]2025 Aug 31;14(8):4774-4790. PMID: 40950658
Solvent & Solubility
H2O : 116.67 mg/mL (270.98 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (232.26 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Li Y, et al. Mechanism of hepatic targeting via oral administration of DSPE-PEG-Cholic acid-modified nanoliposomes. Int J Nanomedicine. 2017 Feb 28;12:1673-1684. [Content Brief]
[2]. Pan X, et al. Cholic acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Drug Metab Dispos. 2017 Apr;45(4):346-352. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.3226 mL | 11.6131 mL | 23.2261 mL | 58.0653 mL |
| 5 mM | 0.4645 mL | 2.3226 mL | 4.6452 mL | 11.6131 mL | |
| 10 mM | 0.2323 mL | 1.1613 mL | 2.3226 mL | 5.8065 mL | |
| 15 mM | 0.1548 mL | 0.7742 mL | 1.5484 mL | 3.8710 mL | |
| 20 mM | 0.1161 mL | 0.5807 mL | 1.1613 mL | 2.9033 mL | |
| 25 mM | 0.0929 mL | 0.4645 mL | 0.9290 mL | 2.3226 mL | |
| 30 mM | 0.0774 mL | 0.3871 mL | 0.7742 mL | 1.9355 mL | |
| 40 mM | 0.0581 mL | 0.2903 mL | 0.5807 mL | 1.4516 mL | |
| 50 mM | 0.0465 mL | 0.2323 mL | 0.4645 mL | 1.1613 mL | |
| 60 mM | 0.0387 mL | 0.1936 mL | 0.3871 mL | 0.9678 mL | |
| 80 mM | 0.0290 mL | 0.1452 mL | 0.2903 mL | 0.7258 mL | |
| 100 mM | 0.0232 mL | 0.1161 mL | 0.2323 mL | 0.5807 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cholic acid sodium Related Classifications
HY-N0324A Related Classifications
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