1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Cholic acid sodium

Cholic acid sodium 

Cat. No.: HY-N0324A Purity: >98.0%
Handling Instructions

Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

For research use only. We do not sell to patients.

Cholic acid sodium Chemical Structure

Cholic acid sodium Chemical Structure

CAS No. : 361-09-1

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10 mM * 1 mL in Water USD 66 In-stock
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100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

In Vitro

Cholic acid competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway[1].

Clinical Trial
Molecular Weight

430.55

Formula

C₂₄H₃₉NaO₅

CAS No.

361-09-1

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 250 mg/mL (580.65 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3226 mL 11.6131 mL 23.2261 mL
5 mM 0.4645 mL 2.3226 mL 4.6452 mL
10 mM 0.2323 mL 1.1613 mL 2.3226 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

HepG2 cells are pretreated with the inhibitors NaN3 (1 mg/mL), Genistein (50 μg/mL), MβCD (10 mM), Nystatin (50 μg/mL), Chlorpromazine (10 μg/mL), and Cholic acid (1 mg/mL) for 30 min. After removing the inhibitors, the cells are incubated with CA-LPs for 2 h, and the cellular uptake of LPs is determined in the "In vitro cellular uptake assays" section[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: >98.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Cholic acidEndogenous MetaboliteInhibitorinhibitorinhibit

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Cholic acid sodium
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HY-N0324A
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