1. Others
    Metabolic Enzyme/Protease
  2. Estrogen Receptor/ERR
    Endogenous Metabolite
  3. Estrone

Estrone (Synonyms: E1; Oestrone)

Cat. No.: HY-B0234 Purity: 99.86%
Handling Instructions

Estrone is an estrogenic hormone.

For research use only. We do not sell to patients.

Estrone Chemical Structure

Estrone Chemical Structure

CAS No. : 53-16-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 102 In-stock
Estimated Time of Arrival: December 31
10 g USD 168 In-stock
Estimated Time of Arrival: December 31
50 g   Get quote  

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Description

Estrone is an estrogenic hormone. Target: Estrogen Receptor/ERR Estrone (E1) is an estrogenic hormone secreted by the ovary as well as adipose tissue with the chemical name of 3-hydroxyestra-1,3,5(10)-triene-17-one and the chemical formula C18H22O2. Estrone is one of several natural estrogens, which also include estriol and estradiol. Estrone is the least abundant of the three hormones; estradiol is present almost always in the reproductive female body, and estriol is abundant primarily during pregnancy. Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol. It is the predominant estrogen in postmenopausal women [1, 2].

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

270.37

Formula

C₁₈H₂₂O₂

CAS No.

53-16-7

SMILES

C[[email protected]]1([[email protected]](CC2)([H])[[email protected]]3([H])CCC4=C(C=CC(O)=C4)[[email protected]@]3([H])CC1)C2=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (123.28 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6986 mL 18.4932 mL 36.9864 mL
5 mM 0.7397 mL 3.6986 mL 7.3973 mL
10 mM 0.3699 mL 1.8493 mL 3.6986 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (9.25 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.25 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.86%

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Estrone
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