Art. -Nr.: HY-B0234

Estrone

(Synonyms: E1; Oestrone)

6 Cited Publications

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Based on 6 publication(s) in Google Scholar

Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells.

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Reinheit: 99.96%
CAS. Nr.: 53-16-7
Formel: C₁₈H₂₂O₂
Molecular Weight:270.37

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Estrone Chemical Structure

CAS. Nr.: 53-16-7

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (6)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

Alle Estrogen Receptor/ERR Isoform-spezifische Produkte anzeigen :

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	600 nM Compound: E1	Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol	[PMID: 18372081]
HEK293	IC₅₀	810 nM Compound: E1	Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADH Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADH	[PMID: 18372081]
HeLa	EC₅₀	0.7 nM Compound: estrone	Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor alpha. Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor alpha.	[PMID: 11906280]
HeLa	EC₅₀	2.1 nM Compound: estrone	Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor beta. Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor beta.	[PMID: 11906280]
HeLa	EC₅₀	166 nM Compound: estrone	Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay at 10 uM Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay at 10 uM	[PMID: 16610787]
HeLa	EC₅₀	26 nM Compound: estrone	Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay	[PMID: 16610787]
K562	IC₅₀	>10 μM Compound: Estrone	TP_TRANSPORTER: drug resistance(SN-38) in BCRP-expressing K562 cells TP_TRANSPORTER: drug resistance(SN-38) in BCRP-expressing K562 cells	[PMID: 12533678]
K562	IC₅₀	3 μM Compound: Estrone	TP_TRANSPORTER: drug resistance(Mitoxantrone) in BCRP-expressing K562 cells TP_TRANSPORTER: drug resistance(Mitoxantrone) in BCRP-expressing K562 cells	[PMID: 12533678]
Sf9	IC₅₀	96 nM Compound: 1, E1	Displacement of [3H]17beta-estradiol from human ERalpha expressed in SF9 cells Displacement of [3H]17beta-estradiol from human ERalpha expressed in SF9 cells	[PMID: 19836949]
T47D	IC₅₀	0.33 μM Compound: E1	Inhibition of 17-beta HSD1 in T47D cells Inhibition of 17-beta HSD1 in T47D cells	[PMID: 16480268]
T47D	IC₅₀	218 nM Compound: E1, estrone	Inhibition of 17beta-HSD1 in human T47D cells assessed as inhibition of transformation of [14C]-estrone into [14C]estrogen Inhibition of 17beta-HSD1 in human T47D cells assessed as inhibition of transformation of [14C]-estrone into [14C]estrogen	[PMID: 18035543]

In Vitro

Estrone is the main endogenous estrogen in postmenopausal women^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 53-16-7
Appearance Solid
Molecular Weight 270.37
Formel C₁₈H₂₂O₂
Color White to off-white
SMILES

C[C@]1([C@](CC2)([H])[C@]3([H])CCC4=C(C=CC(O)=C4)[C@@]3([H])CC1)C2=O
Synonyms

E1; Oestrone
Structure Classification
- Phenols
- Monophenols
- Steroids
Initial Source
- Microorganisms
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (6)

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Journal Impact Factor

Biosens Bioelectron

Split aptamer regulated CRISPR/Cas12a biosensor for 17β-estradiol through a gap-enhanced Raman tags based lateral ﬂow strategy. [Abstract]

2022 Nov 1:215:114548. PMID: 35870335
Anal Chem

High-Throughput Reactive Desorption Electrospray Ionization Mass Spectrometry for Targeted Derivatization and Analysis of Poorly Ionized Small Molecules. [Abstract]

2026 Jun 16;98(23):16962-16970. PMID: 42223360
Environ Health (Wash)

Fish Skin Mucus Vitellogenin as a Noninvasive, Sensitive Biomarker for Aquatic Xenoestrogens. [Abstract]

2025 Jan 10;3(4):414-424. PMID: 40270534
Cell Rep Methods

RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [Abstract]

2023 Oct 23;3(10):100599. PMID: 37797618
J Cell Mol Med

CXADR-like membrane protein protects against heart injury by preventing excessive pyroptosis after myocardial infarction. [Abstract]

2020 Dec;24(23):13775-13788. PMID: 33084169

Estrone purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2020 Dec;24(23):13775-13788. [Abstract]

The mRNA and protein levels of CLMP from male primary fibroblasts in the estrogen (Estrone (300 pg/mL; 48 h)) treatment and normal group.

Estrone purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2020 Dec;24(23):13775-13788. [Abstract]

The mRNA and protein levels of CLMP from female primary fibroblasts in the estrogen ((Estrone (300 pg/mL; 48 h)) ) treatment and normal group.
Physiol Rep

Estrogen-dependent gene regulation: Molecular basis of TIMP-1 as a sex-specific biomarker for acute lung injury. [Abstract]

2024 Sep;12(17):e70047. PMID: 39267201

Estrone purchased from MedChemExpress. Usage Cited in: Physiol Rep. 2024 Sep;12(17):e70047. [Abstract]

IMR-90 and MLg cells were treated with 100 nM E1 (Estrone) or E2 for 6 h. TIMP-1 mRNA expression was measured using qPCR. The results showed that both E1 (Estrone) and E2 could induce TIMP-1 expression in IMR-90 cells at the mRNA level.

Estrone purchased from MedChemExpress. Usage Cited in: Physiol Rep. 2024 Sep;12(17):e70047. [Abstract]

MLg cells were treated with or without 100 nM E1 (Estrone) for 24 h as indicated. MLg cells were immunostained for TIMP-1 (green). The nuclei were stained with DAPI. The results showed that TIMP-1 protein was induced in MLg fibroblasts 24 h after treatment with E1 (Estrone). Scale bar = 100 μm. ns, p > 0.05.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (92.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.6986 mL

18.4932 mL

36.9864 mL

5 mM

0.7397 mL

3.6986 mL

7.3973 mL

10 mM

0.3699 mL

1.8493 mL

3.6986 mL

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (9.25 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (9.25 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Caupos E, et al. Photodegradation of estrone enhanced by dissolved organic matter under simulated sunlight. Water Res. 2011;45(11):3341-3350. [Content Brief]

[2]. de Padua Mansur A, et al. Long-term prospective study of the influence of estrone levels on events in postmenopausal women with or at high risk for coronary artery disease. ScientificWorldJournal. 2012;2012:363595. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.6986 mL	18.4932 mL	36.9864 mL	92.4659 mL
	5 mM	0.7397 mL	3.6986 mL	7.3973 mL	18.4932 mL
	10 mM	0.3699 mL	1.8493 mL	3.6986 mL	9.2466 mL
	15 mM	0.2466 mL	1.2329 mL	2.4658 mL	6.1644 mL
	20 mM	0.1849 mL	0.9247 mL	1.8493 mL	4.6233 mL
	25 mM	0.1479 mL	0.7397 mL	1.4795 mL	3.6986 mL
	30 mM	0.1233 mL	0.6164 mL	1.2329 mL	3.0822 mL
	40 mM	0.0925 mL	0.4623 mL	0.9247 mL	2.3116 mL
	50 mM	0.0740 mL	0.3699 mL	0.7397 mL	1.8493 mL
	60 mM	0.0616 mL	0.3082 mL	0.6164 mL	1.5411 mL
	80 mM	0.0462 mL	0.2312 mL	0.4623 mL	1.1558 mL

Keywords

Estrone

6 Cited Publications

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Estrone

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Publications Citing Use of MedChemExpress (MCE) Estrone

Alle Estrogen Receptor/ERR Isoform-spezifische Produkte anzeigen

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (6)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Estrone Related Classifications

Art. -Nr.: HY-B0234