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Cat. No.: HY-14585

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Estrone O-sulfamate

(Synonyms: Estrone 3-O-sulfamate)

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Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent steroid sulfatase (STS) inhibitor. Estrone O-sulfamate has inhibitory activity for STS in a placental microsomes (P.M.) preparation and in MCF-7 cells with IC₅₀ values of 18 nM and 0.83 nM, respectively. Estrone O-sulfamate can be used for the research of cancer.

For research use only. We do not sell to patients.

Purity: 99.99%
CAS No.: 148672-09-7
Formula: C₁₈H₂₃NO₄S
Molecular Weight:349.44

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Estrone O-sulfamate Chemical Structure

CAS No.: 148672-09-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.02 μM Compound: EMATE	Inhibitory activity against human steroid sulfatase over-expressed in CHO cells Inhibitory activity against human steroid sulfatase over-expressed in CHO cells	[PMID: 15293998]
CHO	IC₅₀	0.03 μM Compound: 1	Inhibitory activity against Steroid sulfatase expressed in CHO cells Inhibitory activity against Steroid sulfatase expressed in CHO cells	[PMID: 14552755]
CHO	IC₅₀	0.03 μM Compound: EMATE	Inhibitory concentration against human steroid sulfatase expressed in CHO cells Inhibitory concentration against human steroid sulfatase expressed in CHO cells	[PMID: 15686949]
HCT-116	IC₅₀	0.9 μM Compound: 1; EMATE	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 34458740]
HEK293	IC₅₀	0.9 nM Compound: 1	Inhibition of human placental steroid sulfatase expressed in HEK293 cells using [3H] E1S as substrate after 2 hrs by liquid scintillation counting method Inhibition of human placental steroid sulfatase expressed in HEK293 cells using [3H] E1S as substrate after 2 hrs by liquid scintillation counting method	[PMID: 31255926]
HEK293	IC₅₀	0.9 nM Compound: 10; EMATE	Inhibition of human placental estrone sulfatase expressed in HEK293 cells using [3H]E1S as substrate incubated for 2 hrs by liquid scintillation counting method Inhibition of human placental estrone sulfatase expressed in HEK293 cells using [3H]E1S as substrate incubated for 2 hrs by liquid scintillation counting method	[PMID: 26974384]
HEK293	IC₅₀	1.6 nM Compound: 10; EMATE	Inhibition of estrone sulfatase (unknown origin) transfected in HEK293 cells using [3H]E1S as substrate incubated for 2 hrs by liquid scintillation counting method Inhibition of estrone sulfatase (unknown origin) transfected in HEK293 cells using [3H]E1S as substrate incubated for 2 hrs by liquid scintillation counting method	[PMID: 26974384]
HEK293	IC₅₀	1.6 nM Compound: 3-Sulfamoylestrone (EMATE)	Inhibition of steroid sulfatase activity by the compound was determined in human embryonic kidney (HEK)-293 cells transfected with a sulfatase expression vector (pCMV-sulfa) using 100 uM of [3H]E1S Inhibition of steroid sulfatase activity by the compound was determined in human embryonic kidney (HEK)-293 cells transfected with a sulfatase expression vector (pCMV-sulfa) using 100 uM of [3H]E1S	[PMID: 11087571]
HEK293	IC₅₀	2.4 nM Compound: 3-Sulfamoylestrone (EMATE)	Inhibition of steroid sulfatase activity by the compound was determined in human embryonic kidney (HEK)-293 cells transfected with a sulfatase expression vector (pCMV-sulfa) using 100 uM of [14C]-DHEAS Inhibition of steroid sulfatase activity by the compound was determined in human embryonic kidney (HEK)-293 cells transfected with a sulfatase expression vector (pCMV-sulfa) using 100 uM of [14C]-DHEAS	[PMID: 11087571]
HeLa	IC₅₀	0.63 μM Compound: 1; EMATE	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 34458740]
HepG2	IC₅₀	0.85 μM Compound: 1; EMATE	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 34458740]
JEG-3	IC₅₀	3.2 nM Compound: 10; EMATE	Inhibition of estrone sulfatase in human JEG-3 cells using [3H]-estrone sulphate as substrate incubated for 4 hrs by liquid scintillation counting method Inhibition of estrone sulfatase in human JEG-3 cells using [3H]-estrone sulphate as substrate incubated for 4 hrs by liquid scintillation counting method	[PMID: 26974384]
JEG-3	IC₅₀	7600 nM Compound: EIS	Reversible inhibition of steroid sulfatase in human JEG3 cells using [3H] E1S as substrate by scintillation counting method Reversible inhibition of steroid sulfatase in human JEG3 cells using [3H] E1S as substrate by scintillation counting method	[PMID: 32122754]
MCF7	GI₅₀	22.8 μM Compound: 2	Growth inhibition of human MCF7 cells Growth inhibition of human MCF7 cells	[PMID: 25992880]
MCF7	IC₅₀	0.07 μM Compound: 1; EMATE	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 34458740]
MCF7	IC₅₀	0.08 μM Compound: EMATE	Inhibitory activity againist Estrone sulfatase from MCF-7 cells (placental microsomes) Inhibitory activity againist Estrone sulfatase from MCF-7 cells (placental microsomes)	[PMID: 11992772]
MCF7	IC₅₀	0.83 nM Compound: EMATE	Inhibition of steroid sulfatase in human MCF7 cells using [3H]E1S as substrate after 20 hrs by scintillation spectrometry Inhibition of steroid sulfatase in human MCF7 cells using [3H]E1S as substrate after 20 hrs by scintillation spectrometry	[PMID: 22455789]
MCF7	IC₅₀	22.8 μM Compound: 13 (EMATE)	Anti-proliferative activity against MCF-7 human breast cancer cells was determined by using MCF-7 plate assay Anti-proliferative activity against MCF-7 human breast cancer cells was determined by using MCF-7 plate assay	[PMID: 15149660]
MCF7	IC₅₀	65 pM Compound: 1; EMATE	Irreversible inhibition of estrone sulfatase in human MCF7 cells using [3H]estrone sulfate as substrate preincubated for 2 hrs followed by substrate addition measured after 20 hrs Irreversible inhibition of estrone sulfatase in human MCF7 cells using [3H]estrone sulfate as substrate preincubated for 2 hrs followed by substrate addition measured after 20 hrs	10.1039/C6MD00113K
MCF7	IC₅₀	65 pM Compound: 1, EMATE	Inhibition of STS in human MCF7 cells Inhibition of STS in human MCF7 cells	[PMID: 26163883]
MGC-803	IC₅₀	0.48 μM Compound: 1; EMATE	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 34458740]
MKN-45	IC₅₀	0.54 μM Compound: 1; EMATE	Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability after 24 hrs by CCK-8 assay	[PMID: 34458740]

In Vitro

Estrone O-sulfamate (Estrone 3-O-sulfamate) has inhibitory activity for STS in a placental microsomes (P.M.) preparation and in MCF-7 cells with IC₅₀ values of 18 nM and 0.83 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 148672-09-7
Appearance Solid
Molecular Weight 349.44
Formula C₁₈H₂₃NO₄S
Color White to off-white
SMILES

C[C@@]12[C@](CCC2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(OS(N)(=O)=O)C=C4CC3
Synonyms

Estrone 3-O-sulfamate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. L W Lawrence Woo, et al. Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors. Bioorg Med Chem. 2012 Apr 15;20(8):2506-19. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Estrone O-sulfamate

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