Sulfatase inhibitors for recidivist breast cancer treatment: A chemical review

  • Eur J Med Chem. 2016 May 23:114:170-90. doi: 10.1016/j.ejmech.2016.02.054.
Ramanpreet Shah  1 ,  Jatinder Singh  1 ,  Dhandeep Singh  2 ,  Amteshwar Singh Jaggi  1 ,  Nirmal Singh  1
Affiliations
  • 1. Department of Pharmaceutical Sciences and Drug Research, Pharmaceutical Chemistry Research Lab, Punjabi University, Patiala, 147002, India.
  • 2. Department of Pharmaceutical Sciences and Drug Research, Pharmaceutical Chemistry Research Lab, Punjabi University, Patiala, 147002, India. Electronic address: [email protected].
PMID: 26974384 DOI: 10.1016/j.ejmech.2016.02.054
Abstract

Steroid Sulfatase (STS) plays a momentous role in the conversion of sulfated Steroids, which are biologically inactive, into biologically active un-sulfated steroid Hormones, which support the development and growth of a number of hormone-dependent cancers, including breast Cancer. Therefore, inhibitors of STS are supposed to be potential drugs for the treatment of breast and Other steroid-dependent cancers. The present review concentrates on broad chemical classification of Steroid Sulfatase inhibitors. The inhibitors reviewed are classified into four main categories: Steroid sulfamate based inhibitors; Steroid non-sulfamate based inhibitors; Non-steroidal sulfamate based inhibitors; Non-steroidal non-sulfamate based inhibitors. A succinct overview of current treatment of Cancer, estradiol precursors, STS enzyme and its role in breast Cancer is herein described.

Keywords
Breast cancer; Non-steroidal non-sulfamate based inhibitors; Non-steroidal sulfamate based inhibitors; Steroid non-sulfamate based inhibitors; Steroid sulfamate based inhibitors; Sulfatase inhibitor's chemistry.