Lipid-lowering agent-1
Lipid-lowering agent-1 is a potent lipid-lowering agent. Lipid-lowering agent-1 has significant pharmacological effects on the inhibition of low-density lipoprotein cholesterol (LDLC) and promotion of high-density lipoprotein cholesterol (HDLC) production. Lipid-lowering agent-1 shows potent hypolipidemic effect in high-fat diet rats.
For research use only. We do not sell to patients.
- CAS No.: 2304859-34-3
- Formula: C26H19ClF3NO6S
- Molecular Weight:565.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Lipid-lowering agent-1 (compound 1m) (12.5 μM; 72 hours) does not exhibit significant toxicity to both HepG2 and 3T3-L1 cells at a high concentration[1].
Lipid-lowering agent-1 (10 μM; 24 hours) has significant pharmacological effects on the inhibition of LDLC and promotion of HDLC production[1].
Lipid-lowering agent-1 (10 μM; 24 hours) inhibits the conversion of 3T3-L1 cells from pre-adipose to adipose-like with the inhibition of triglycerides (TG) by 70.4%[1].
Lipid-lowering agent-1 (10 μM; 10 days) decreases yellow lipid droplets effectively in 3T3-L1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 and 3T3-L1[1]
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Concentration:12.5 μM
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Incubation Time:72 hours
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Result:Did not exhibit significant toxicity to both HepG2 and 3T3-L1 cells at a high concentration.
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Cell Line:3T3-L1 cells[1]
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Concentration:10 μM
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Incubation Time:24 hours
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Result:Inhibited the conversion of 3T3-L1 cells from pre-adipose to adipose-like with the inhibition of triglycerides (TG) by 70.4%
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:High-fat diet (HFD) rats[1]
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Dosage:15 mg/kg
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Administration:i.g., daily for 40 or 80 days
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Result:Reduced blood cholesterolby, triglycerides and LDLC by 19.6%, 34.52%, and 41.49% after dosing 40 days, moreover the three indexes was still better than that of berberine after dosing 80 days.
Chemical Information
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CAS No. 2304859-34-3
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Molecular Weight 565.95
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Formula C26H19ClF3NO6S
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SMILES
O=S(OC1=C(C=CC2=CC3=[N+](C=C21)CCC4=CC5=C(OCO5)C=C34)OC)(C6=CC(C(F)(F)F)=CC=C6)=O.[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lipid-lowering agent-1 Related Classifications
HY-115914 Related Classifications
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