Calcium stearate
Based on 22 publication(s) in Google Scholar
Calcium stearate is an orally active long-chain dietary saturated fatty acid that can significantly reduce visceral fat by inducing apoptosis of preadipocytes. Calcium stearate can be used in the study of cardiovascular and metabolic diseases.
For research use only. We do not sell to patients.
- CAS No.: 1592-23-0
- Formula: C36H70CaO4
- Molecular Weight:607.02
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- Purity & Documentation
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Publications Citing Use of MedChemExpress (MCE) Calcium stearate
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Bioact Mater. 2023 Nov 9:33:85-99. [Abstract]
- J Adv Res. 2025 Aug:74:589-607. [Abstract]
- Cell Death Dis. 2025 Nov 24;16(1):857. [Abstract]
- Cell Death Dis. 2020 Sep 15;11(9):756. [Abstract]
- Cell Death Dis. 2019 May 28;10(6):416. [Abstract]
- J Transl Med. 2025 Sep 24;23(1):1011. [Abstract]
- Proc Natl Acad Sci U S A. 2026 Feb 10;123(6):e2513080122. [Abstract]
- Free Radic Biol Med. 2023 Jun:202:110-120. [Abstract]
- Cell Rep. 2025 Nov 25;44(11):116496. [Abstract]
- Nanoscale Adv. 2025 Nov 21. [Abstract]
- Chem Biol Interact. 2025 Sep 26:111758. [Abstract]
- Mol Nutr Food Res. 2023 Jan;67(2):e2200429. [Abstract]
- FASEB J. 2024 Jul 15;38(13):e23806. [Abstract]
- BMC Cancer. 2025 May 21;25(1):906. [Abstract]
- J Biol Chem. 2024 Jun;300(6):107351. [Abstract]
- Biofuel Bioprod Bior. 2025 Sep 3;19(5):1378-1399.
- Pathol Res Pract. 2023 Aug:248:154641. [Abstract]
- J Pharm Biomed Anal. 2025 Nov 23:270:117281. [Abstract]
- Plant Pathol. 2025 Dec 30.
- Eur J Lipid Sci Technol. 2023 Feb 25.
- Reprod Domest Anim. 2024 Nov;59(11):e14746. [Abstract]
Customer Validation & Images
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Cell Imaging/Staining
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IF
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RT-PCR
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Cell Imaging/Staining
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Biological Activity
Calcium stearate (50 μM; 48 h) increases apoptosis of 3T3L1 preadipocytes, decreases the expression of cIAP2 and Bcl2, and increases the expression of Bax[1]. Calcium stearate (0-200 μM; 48 h) shows a dose-dependent cytotoxicity to 3T3L1 preadipocytes starting at 35 μM and reaching a maximum at 100 μM, and increases caspase-3 activity in preadipocytes after 48 h of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1592-23-0
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Appearance Solid
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Molecular Weight 607.02
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Formula C36H70CaO4
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.[Ca+2]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Publications (22)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Bioact Mater
Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus. [Abstract]2023 Nov 9:33:85-99. PMID: 38024229
Calcium stearate purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Nov 9:33:85-99. [Abstract]
Stearic acid (300 μM; 24 h). Analysis of fatty acid production in PDLCs after exosomes treatment with or without C75 application by liquid chromatography-mass spectrometry.
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J Adv Res
Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy. [Abstract]2025 Aug:74:589-607. PMID: 39353532 -
Cell Death Dis
Elovl7 sensitizes podocytes to ferroptosis in podocytopathy by elongating polyunsaturated fatty acids. [Abstract]2025 Nov 24;16(1):857. PMID: 41285716
Calcium stearate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Nov 24;16(1):857. [Abstract]
Stearic acid (SA; 80 μM; 24 h). Representative images of oil red staining in γ-LA, OA or SA stimulated MPC5 cells.
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Cell Death Dis
Acyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition. [Abstract]2020 Sep 15;11(9):756. PMID: 32934217 -
Cell Death Dis
Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist?. [Abstract]2019 May 28;10(6):416. PMID: 31138790 -
J Transl Med
Inhibition of DDR1 potentiates carbon ion radiotherapy by promoting ferroptosis and immunogenic death in head and neck squamous cell carcinoma. [Abstract]2025 Sep 24;23(1):1011. PMID: 40993737 -
Proc Natl Acad Sci U S A
Ancestral and local adaptation contribute to dispersal out of the Qinghai-Tibet Plateau in a bumblebee. [Abstract]2026 Feb 10;123(6):e2513080122. PMID: 41587327 -
Free Radic Biol Med
Ferroptosis signaling promotes the release of misfolded proteins via exosomes to rescue ER stress in hepatocellular carcinoma. [Abstract]2023 Jun:202:110-120. PMID: 36997100 -
Cell Rep
A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential. [Abstract]2025 Nov 25;44(11):116496. PMID: 41166305 -
Nanoscale Adv
Dexamethasone-loaded lipid-polymeric nanoparticles to improve therapy for cisplatin-induced sensorineural hearing loss. [Abstract]2025 Nov 21. PMID: 41278499 -
Chem Biol Interact
Mechanisms and targeted prevention of chronic pancreatitis-acinar to ductal metaplasia caused by a low concentration of di-(2-ethylhexyl)-phthalate. [Abstract]2025 Sep 26:111758. PMID: 41016453
Calcium stearate purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2025 Sep 26:111758. [Abstract]
Stearic acid (SA; 10 μM; 6 h). IF staining analysis of CK19.
Calcium stearate purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2025 Sep 26:111758. [Abstract]
Stearic acid (SA; 10 μM; 6 h). Triplicate qPCR analysis of CTGF.
Calcium stearate purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2025 Sep 26:111758. [Abstract]
Stearic acid (SA; 10 μM; 6 h). Intracellular ROS levels.
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Mol Nutr Food Res
Consumption of Saturated Fatty Acids-Rich Lard Benefits Recovery of Experimental Arthritis by Activating PPAR-γ. [Abstract]2023 Jan;67(2):e2200429. PMID: 36433679 -
FASEB J
SREBP-1-mediated lipogenesis confers resistance to ferroptosis and improves endothelial injury. [Abstract]2024 Jul 15;38(13):e23806. PMID: 38970404 -
BMC Cancer
APOL4-mediated intracellular cholesterol trafficking is essential for glioblastoma cell growth. [Abstract]2025 May 21;25(1):906. PMID: 40399861 -
J Biol Chem
STAT3 activation of SCAP-SREBP-1 signaling upregulates fatty acid synthesis to promote tumor growth. [Abstract]2024 Jun;300(6):107351. PMID: 38718868 -
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Pathol Res Pract
Sphingosine kinase 1 regulates lipid metabolism to promote progression of kidney renal clear cell carcinoma. [Abstract]2023 Aug:248:154641. PMID: 37467634 -
J Pharm Biomed Anal
Identification of new small molecule inhibitors of PD-1/PD-L1 interaction by a comprehensive ligand fishing system. [Abstract]2025 Nov 23:270:117281. PMID: 41308584 -
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Reprod Domest Anim
6-Gingerol and Astaxanthin Mitigate the Effects of Stearic Acid in Pig Oocyte Maturation. [Abstract]2024 Nov;59(11):e14746. PMID: 39582146
Solvent & Solubility
Ethanol : < 1 mg/mL (insoluble)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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