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  4. Stearic acid

Stearic acid is an orally active long-chain dietary saturated fatty acid that can significantly reduce visceral fat by inducing apoptosis of preadipocytes. Stearic acid can be used in the study of cardiovascular and metabolic diseases.

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CAS No. : 57-11-4

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Based on 22 publication(s) in Google Scholar

Other Forms of Stearic acid:

Stearic acid Related Antibodies

Top Publications Citing Use of Products

    Stearic acid purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Nov 24;16(1):857.  [Abstract]

    Stearic acid (SA; 80 μM; 24 h). Representative images of oil red staining in γ-LA, OA or SA stimulated MPC5 cells.

    Stearic acid purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2025 Sep 26:111758.  [Abstract]

    Stearic acid (SA; 10 μM; 6 h). IF staining analysis of CK19.

    Stearic acid purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2025 Sep 26:111758.  [Abstract]

    Stearic acid (SA; 10 μM; 6 h). Triplicate qPCR analysis of CTGF.

    Stearic acid purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2025 Sep 26:111758.  [Abstract]

    Stearic acid (SA; 10 μM; 6 h). Intracellular ROS levels.

    Stearic acid purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Nov 9:33:85-99.

    Stearic acid (300 μM; 24 h). Analysis of fatty acid production in PDLCs after exosomes treatment with or without C75 application by liquid chromatography-mass spectrometry.

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    Description

    Stearic acid is an orally active long-chain dietary saturated fatty acid that can significantly reduce visceral fat by inducing apoptosis of preadipocytes. Stearic acid can be used in the study of cardiovascular and metabolic diseases[1].

    Cellular Effect
    Cell Line Type Value Description References
    COLO 205 IC50
    > 200 μM
    Compound: R9C1 Table4
    Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay
    Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay
    		[PMID: 20405849]
    HT-29 IC50
    > 200 μM
    Compound: R9C1 Table4
    Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
    Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
    		[PMID: 20405849]
    In Vitro

    Stearic acid (50 μM; 48 h) increases apoptosis of 3T3L1 preadipocytes, decreases the expression of cIAP2 and Bcl2, and increases the expression of Bax[1].
    Stearic acid (0-200 μM; 48 h) shows a dose-dependent cytotoxicity to 3T3L1 preadipocytes starting at 35 μM and reaching a maximum at 100 μM, and increases caspase-3 activity in preadipocytes after 48 h of treatment[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Stearic acid Related Antibodies
    In Vivo

    Stearic acid (17% stearic acid/3% safflower oil diet, p.o.; ad libitum; 18 weeks and 3 days) reduces bone mineral density, abdominal fat content, and serum glucose concentration, and increases serum monocyte chemoattractant protein-1 levels in female athymic mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    284.48

    Formula

    C18H36O2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CCCCCCCCCCCCCCCCCC(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Store at room temperature 3 years

    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    Ethanol : 25 mg/mL (87.88 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.5152 mL 17.5759 mL 35.1519 mL
    5 mM 0.7030 mL 3.5152 mL 7.0304 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% EtOH    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (8.79 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.87%

    SDS (393 KB)

    COA (237 KB) HNMR (239 KB) RP-HPLC (240 KB) MS (111 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol 1 mM 3.5152 mL 17.5759 mL 35.1519 mL 87.8796 mL
    5 mM 0.7030 mL 3.5152 mL 7.0304 mL 17.5759 mL
    10 mM 0.3515 mL 1.7576 mL 3.5152 mL 8.7880 mL
    15 mM 0.2343 mL 1.1717 mL 2.3435 mL 5.8586 mL
    20 mM 0.1758 mL 0.8788 mL 1.7576 mL 4.3940 mL
    25 mM 0.1406 mL 0.7030 mL 1.4061 mL 3.5152 mL
    30 mM 0.1172 mL 0.5859 mL 1.1717 mL 2.9293 mL
    40 mM 0.0879 mL 0.4394 mL 0.8788 mL 2.1970 mL
    50 mM 0.0703 mL 0.3515 mL 0.7030 mL 1.7576 mL
    60 mM 0.0586 mL 0.2929 mL 0.5859 mL 1.4647 mL
    80 mM 0.0439 mL 0.2197 mL 0.4394 mL 1.0985 mL
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    Stearic acid Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Stearic acid57-11-4Environmental PollutantsEndogenous MetaboliteApoptosisEnvironmental ContaminantsInhibitorinhibitorinhibit

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