Intralipid 20%
Based on 4 publication(s) in Google Scholar
Intralipid 20% is a safe fat emulsion that can be used as a nutritional supplement. Intralipid 20% effectively inhibits the opening of the mitochondrial permeability transition pore, effectively protecting the heart from ischaemia-reperfusion injury and has some potential to modulate the innate immune response.
For research use only. We do not sell to patients.
- CAS No.: 68890-65-3
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Storage:
Store at 4°C, do not freeze
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Intralipid 20%
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Customer Validation & Images
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In Vivo Efficacy Study
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In Vivo Efficacy Study
Biological Activity
Intralipid 20% (0-0.2 mg/mL) specifically protects immune cells from paclitaxel, but has no effect on tumor cells[1].
Intralipid 20% (0-0.2 mg/mL, 3 days) promotes polarisation of M0, M1 and M2 macrophages to an M1-like phenotype[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Intralipid pretreatment promotes the accumulation of paclitaxel in tumour tissue and induces higher levels of apoptosis in tumour cells. Increased distribution of paclitaxel in mouse RES organs and enhanced inhibition of tumour growth[1].
Intralipid (5 mL/kg) is more effective than cyclosporin-A in protecting the heart from I/R injury in SD rats, reducing the size of myocardial infarction by approximately 40%[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 68890-65-3
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Appearance Liquid (Density: 0.99 g/cm3)
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Color White to off-white
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SMILES
[Intralipid 20%]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at 4°C, do not freeze
Publications (4)
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Journal Impact Factor
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Most Recent
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Nat Commun
Paraventricular hypothalamic input to anterior cingulate cortex controls food preferences in chronic visceral pain mice. [Abstract]2025 Jul 1;16(1):5943. PMID: 40593837
Intralipid 20% purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 1;16(1):5943. [Abstract]
Heatmaps of mouse location throughout the free-feeding tests, the consumption of three liquids (i.e., Sucrose, Water, and an Intralipid solution (1.5%)) and time spent in the corresponding zones in the CON and NCI mice.
Intralipid 20% purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 1;16(1):5943. [Abstract]
The percentage of time spent in each food zone and percentage of each type of liquid intake.
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Adv Healthc Mater
2026 Mar 6:e05668. PMID: 41793059 -
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Jingyuan Li, et al. Intralipid, a clinically safe compound, protects the heart against ischemia-reperfusion injury more efficiently than cyclosporine-A. Anesthesiology. 2012 Oct;117(4):836-46. [Content Brief]
[2]. Yen-Ju Chen, et al. Impacts of Intralipid on Nanodrug Abraxane Therapy and on the Innate Immune System. Sci Rep. 2020 Feb 18;10(1):2838. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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