1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite

Enterostatin, human, mouse, rat 

Cat. No.: HY-P1067
Handling Instructions

Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake. Sequence: Ala-Pro-Gly-Pro-Arg;APGPR.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Enterostatin, human, mouse, rat Chemical Structure

Enterostatin, human, mouse, rat Chemical Structure

CAS No. : 117830-79-2

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5 mg USD 180 Get quote

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake. Sequence: Ala-Pro-Gly-Pro-Arg;APGPR.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

In the perfused ratpancreas, Enterostatin, at 100 mM, inhibits the insulin response to 9 mM glucose (by 70%), 0.1 mM tolbutamide (by 40%), and 5 mM arginine (by 70%)[1].

In Vivo

Chronically, enterostatin reduces fat intake, bodyweight, and body fat. This response may involve multiple metabolic effects of enterostatin, which include a reduction of insulin secretion, an increase in sympathetic drive to brown adipose tissue, and the stimulation of adrenal corticosteroid secretion[2]. Enterostatin enhances memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice[3]. A dose of 38 nmol of enterostatin gives a significant inhibition of high-fat food intake, while at a higher dose of 76 nmol the inhibiting effect is lost. During the first hour, after injection of enterostatin, there is even a slight increase in food intake[4].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0139 mL 10.0693 mL 20.1386 mL
5 mM 0.4028 mL 2.0139 mL 4.0277 mL
10 mM 0.2014 mL 1.0069 mL 2.0139 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

496.56

Formula

C₂₁H₃₆N₈O₆

CAS No.

117830-79-2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Enterostatin, human, mouse, rat
Cat. No.:
HY-P1067
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Enterostatin, human, mouse, rat

Cat. No.: HY-P1067