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Results for "

Toll-like receptors (TLRs)

" in MedChemExpress (MCE) Product Catalog:

標的別:	Toll-like Receptor (TLR) (151) AMPK (1) Amyloid-β (2) Antibiotic (10) Apoptosis (9) ATM/ATR (2) Autophagy (35) Bacterial (1) Bcl-2 Family (3) BMX Kinase (2) Btk (2) Complement System (1) Deubiquitinase (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) EBV (1) Endogenous Metabolite (6) ERK (1) HBV (3) HCV (5) HIV (11) HSP (3) HSV (11) IFNAR (2) IKK (1) Influenza Virus (3) Interleukin Related (9) IRAK (2) Isotope-Labeled Compounds (12) Liposome (1) MMP (1) mRNA (10) NF-κB (8) NO Synthase (2) Nucleoside Antimetabolite/Analog (37) p38 MAPK (3) Parasite (24) PD-1/PD-L1 (1) Phosphatase (2) Phosphoramidites (8) PKD (3) PROTACs (1) Pyroptosis (1) Reference Standards (24) RIG-I-like receptor (RLR) (3) SARS-CoV (30) TNF Receptor (7)
研究分野別:	Cancer (92) Cardiovascular Disease (2) Infection (61) Inflammation/Immunology (115) Metabolic Disease (8) Neurological Disease (10)
クリックケミストリー:	Alkynes (4)
Oligonucleotides:	Guanosine (24) Nucleoside Analogs (25) CpG ODNs (14) Phospholipids (1) Adjuvant (4) mRNA (10) Phosphoramidites (8) Guanine (8)

208

阻害剤およびアゴニスト

スクリーニングライブラリ

蛍光色素

生化学アッセイ試薬

ペプチド

天然物

同位体標識化合物

クリックケミストリー

オリゴヌクレオチド

Targets Recommended: Toll-like Receptor (TLR)

製品番号	製品名	Target	研究分野	構造式

HY-13740

Resiquimod 105+ Cited Publications R848; S28463	Toll-like Receptor (TLR) HCV	Inflammation/Immunology Cancer
Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α.

HY-W031727

Hydroxychloroquine 85+ Cited Publications	Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy	Infection Cancer
Hydroxychloroquine (HCQ) is a synthetic oral antimalarial drug that can be used in the study of malaria and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Hydroxychloroquine is a potent autophagic flux inhibitor with antiviral activity (such as SARS-CoV-2 virus) that inhibits Toll-like receptor 7/9 (TLR7/9) signaling .

HY-100461

C29 105+ Cited Publications	Toll-like Receptor (TLR)	Inflammation/Immunology
C29 is a **Toll-like receptor 2 (TLR2) inhibitor. C29 blocks hTLR2/1 and hTLR2/6 signaling with IC₅₀**s of 19.7 and 37.6 μM, respectively .

HY-P1180A

Pam3CSK4 TFA Maximum Cited Publications 19 Publications Verification Pam3Cys-Ser-(Lys)4 TFA	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC₅₀ of 0.47 ng/mL for human TLR1/2 .

HY-B1370

Hydroxychloroquine sulfate 85+ Cited Publications HCQ sulfate	Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy	Infection Cancer
Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro .

HY-113134

25-Hydroxycholesterol Maximum Cited Publications 28 Publications Verification 25-OHC	Endogenous Metabolite	Inflammation/Immunology
25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC₅₀≈65 nM) and selective suppressor of IgA production by B cells.

HY-108471

CU-CPT22 10+ Cited Publications	Toll-like Receptor (TLR)	Cancer
CU-CPT22 is a potent protein complex of **toll-like receptor 1 and 2 (TLR1/2)** inhibitor, and competes with the synthetic triacylated lipoprotein (Pam₃CSK₄) binding to TLR1/2 with a K_i of 0.41 µM. CU-CPT22 blocks Pam₃CSK₄-induced TLR1/2 activation with an IC₅₀ of 0.58 µM .

HY-103698A

TLR7/8 agonist 1 dihydrochloride 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7/8 agonist 1 dihydrochloride is a toll-like receptor *TLR7/TLR8* dual-agonistic imidazoquinoline .

HY-109137

Selgantolimod 1 Publications Verification GS-9688	Toll-like Receptor (TLR) HBV	Infection
Selgantolimod (GS-9688) is an orally active, potent and selective **toll-like receptor 8 (TLR8) agonist for the treatment of hepatitis B virus (HBV)** and human immunodeficiency virus (HIV) infection .

HY-15601

Vesatolimod 10+ Cited Publications GS-9620	Toll-like Receptor (TLR) Apoptosis HBV HCV HIV	Inflammation/Immunology
Vesatolimod (GS-9620) is a potent, selective and orally active agonist of **Toll-Like Receptor (TLR7) with an EC₅₀** of 291 nM.

HY-13773

Motolimod 10+ Cited Publications VTX-2337; VTX-378	Toll-like Receptor (TLR)	Cancer
Motolimod (VTX-2337;VTX-378) is a selective **Toll-like receptor 8 (TLR8) agonist, with an EC₅₀** of approximately 100 nM.

HY-116961

TH1020 10+ Cited Publications	Toll-like Receptor (TLR) Bacterial	Infection Inflammation/Immunology
TH1020 is a potent and selective toll-like receptor 5 (TLR5)/flagellin complex antagonist with an IC₅₀ of 0.85 μM. TH1020 inhbits flagellin-induced *TLR5* signaling. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 and TLR8 .

HY-103698

TLR7/8 agonist 1 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7/8 agonist 1 is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline.

HY-P2036A

FSL-1 TFA 4 Publications Verification	Toll-like Receptor (TLR) MMP HSV Antibiotic	Infection
FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection . FSL-1 TFA induces MMP-9 production through *TLR2* and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells .

HY-109104

Telratolimod 5+ Cited Publications MEDI9197; 3M-052	Toll-like Receptor (TLR)	Cancer
Telratolimod (MEDI9197) is a potent toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity .

HY-103039

TLR7 agonist 2 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 2 is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a LEC of 0.4 μM.

HY-P2036

FSL-1 4 Publications Verification	Toll-like Receptor (TLR) Antibiotic	Infection
FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection .

HY-108472

Loxoribine 7-Allyl-8-oxoguanosine; RWJ 21757	Toll-like Receptor (TLR) Influenza Virus	Infection Cancer
Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist .

HY-115400

1V209 4 Publications Verification TLR7 agonist T7	Toll-like Receptor (TLR)	Cancer
1V209 (TLR7 agonist T7) is a **Toll-like receptor 7 (TLR7)** agonist and has anti-tumor effects. 1V209 can be conjugated with various polysaccharides to improve its water solubility, and enhance its efficacy, and maintain low toxicity .

HY-P1180

Pam3CSK4 Pam3Cys-Ser-(Lys)4	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC₅₀ of 0.47 ng/mL for human TLR1/2 .

HY-111582

BBIQ	Toll-like Receptor (TLR)	Inflammation/Immunology
BBIQ is a imidazoquinoline compound and a potent and selectively **toll-like receptor 7 (TLR7) agonist with an EC₅₀** of 59.1 nM for human TLR7. BBIQ is a powerful vaccine adjuvant that enhances innate immune responses .

HY-150736

ODN 20844 1 Publications Verification	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
ODN 20844, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a *TLR7* and *TLR9* (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 20844 disrupts TLR7- and TLR9-mediated immune cell immune responses. ODN 20844 sequence: 5'-TCCTGGCGc7GGGAAGT-3' .

HY-13740G

Resiquimod R848; S28463	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
Resiquimod (R848) (GMP) is Resiquimod (HY-13740) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist. Resiquimod (GMP) can induce human mMDSC to mature into inflammatory macrophages .

HY-111269

AZD8848 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
AZD8848 is a selective **toll-like receptor 7 (TLR7)** anteagent agonist which is developed for the research of asthma and allergic rhinitis .

HY-110120

DSR-6434 1 Publications Verification	Toll-like Receptor (TLR)	Cancer
DSR-6434 is a potent and selective **Toll-like receptor 7 (TLR7) agonist, with EC₅₀s of 7.2 nM and 4.6 nM for human and mice TLR7**, respectively. DSR-6434 has a strong antitumor effect .

HY-B1370R

Hydroxychloroquine sulfate (Standard) 40+ Cited Publications HCQ sulfate (Standard)	Reference Standards Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy	Infection Cancer
Hydroxychloroquine (sulfate) (Standard) is the analytical standard of Hydroxychloroquine (sulfate). This product is intended for research and analytical applications. Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro .

HY-131952

TLR7/8/9-IN-1 2 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7/8/9-IN-1 is a potent and orally bioavailable small molecule antagonist (IC₅₀ = 43 nM) of **Toll-like receptors 7/8/9 (TLR7/8/9)**.

HY-N14039

Pinus pinaster bark extract	Toll-like Receptor (TLR) Interleukin Related	Neurological Disease Inflammation/Immunology
Pinus pinaster bark extract is extracted from the bark of pine bark with antioxidant, anti-inflammatory and neuroprotective effects. Pinus pinaster bark extract increases **toll-like receptor (TLR) activity, inducing production of IL-10** .

HY-101929

CU-CPT17e 3 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
CU-CPT17e is a potent multi-Toll-like *receptor* (TLR) agonist that activates *TLR3, TLR8, and TLR9*.

HY-150746

ODN 24991	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 24991, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a *TLR3, TLR7* and *TLR9* (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 24991 disrupts TLR3-, TLR7- and TLR9-mediated immune cell immune responses. ODN 24991 sequence: 5'-C-C-T-G-G-C-c7rGm-G-G-G-3' .

HY-134315

8-Nitroguanosine	Nucleoside Antimetabolite/Analog	Others
8-Nitroguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-10018

Toll-like receptor modulator	Toll-like Receptor (TLR)	Inflammation/Immunology
Toll-like receptor modulator is a modulator of *TLR7/8*, which modulates immune function.

HY-177617

Bazlitoran IMO-8400	Toll-like Receptor (TLR)	Inflammation/Immunology
Bazlitoran (IMO-8400) is an oligonucleotide-based *TLR7/8/9* antagonist. Bazlitoran blocks the activation of Toll-like receptors 7, 8, and 9. Bazlitoran inhibits cytokine responses mediated by Toll-like receptors 7, 8, and 9. Bazlitoran is associated with injection site reactions. Bazlitoran improves moderate-to-severe plaque psoriasis .

HY-13740S

Resiquimod-d5 1 Publications Verification R848-d₅; S28463-d₅	Isotope-Labeled Compounds Toll-like Receptor (TLR) HCV	Infection Inflammation/Immunology
Resiquimod-d₅ is deuterium labeled Resiquimod. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α .

HY-P10208A

RKH acetate 1 Publications Verification	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
RKH acetate exerts protective effects against sepsis-induced death and organ damage. RKH acetate can directly bind to **Toll-like receptor** 4 (TLR4) and block TLR4 signal transduction in immune cells .

HY-148980A

Polyinosinic acid sodium 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
Polyinosinic acid sodium is the sodium form of Polyinosinic acid (HY-148980). Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) ligand. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. Polyinosinic acid has potential applications in immune regulation .

HY-148511A

Vidutolimod sodium CMP-001 sodium	Toll-like Receptor (TLR)	Cancer
Vidutolimod sodium is a CpG-A oligodeoxynucleotide. Vidutolimod sodium is a **Toll-like receptor 9 (TLR9)** agonist, which activates plasmacytoid dendritic cells (pDCs) and triggers interferon alpha (IFNα) release, leading to a cascade of anti-tumor immune effects.

HY-150736A

ODN 20844 sodium 1 Publications Verification	Toll-like Receptor (TLR)	Infection
ODN 20844 sodium, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a *TLR7* and *TLR9* (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 20844 sodium disrupts TLR7- and TLR9-mediated immune cell immune responses. ODN 20844 sequence: 5'-TCCTGGCGc7GGGAAGT-3' .

HY-150734A

ODN 2007 sodium	Toll-like Receptor (TLR)	Infection
ODN 2007 sodium, a class B CpG ODN (oligodeoxynucleotide), is a Toll-like receptor (TLR) ligand. ODN 2007 sodium can be used as an immunomodulator, vaccine adjuvant, and enhance immune responses in mammals, fish, and humans. ODN 2007 sequence: 5'-TCGTCGTTGTCGTTTTGTCGTT-3' .

HY-103639A

M62812	Toll-like Receptor (TLR)	Infection
M62812 is a toll-like receptor 4 *(TLR4)* signaling inhibitor. M62812 inhibits endothelial and leukocyte activation and prevents lethal septic shock in mice. M62812 can reduces LPS-induced coagulation and inflammatory responses. M62812 can be used for the research of sepsis .

HY-150746A

ODN 24991 sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 24991 sodium, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a *TLR3, TLR7* and *TLR9* (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 24991 sodium disrupts TLR3-, TLR7- and TLR9-mediated immune cell immune responses. ODN 24991 sequence: 5'-C-C-T-G-G-C-c7rGm-G-G-G-3' .

HY-W031727R

Hydroxychloroquine (Standard)	Reference Standards Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy	Infection Cancer
Hydroxychloroquine (HCQ) is a synthetic oral antimalarial drug that can be used in the study of malaria and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Hydroxychloroquine is a potent autophagic flux inhibitor with antiviral activity (such as SARS-CoV-2 virus) that inhibits Toll-like receptor 7/9 (TLR7/9) signaling .

HY-177617A

Bazlitoran sodium IMO-8400 sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
Bazlitoran sodium (IMO-8400 sodium) is an oligonucleotide-based *TLR7/8/9* antagonist. Bazlitoran sodium blocks the activation of Toll-like receptors 7, 8, and 9. Bazlitoran sodium inhibits cytokine responses mediated by Toll-like receptors 7, 8, and 9. Bazlitoran sodium is associated with injection site reactions. Bazlitoran sodium improves moderate-to-severe plaque psoriasis .

HY-135811A

Desethyl chloroquine diphosphate 2 Publications Verification	Parasite Toll-like Receptor (TLR) Autophagy	Infection
Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and **toll-like receptors (TLRs)**. Desethyl chloroquine diphosphate possesses antiplasmodic activity .

HY-B1370B

(R)-Hydroxychloroquine (R)-HCQ	Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy	Infection
(R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine . Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro .

HY-P1405

Pam3CSK4-Biotin Pam3Cys-Ser-(Lys)4-Biotin	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4-Biotin is biotinylated Pam3CSK4. Pam3CSK4-Biotin is a Toll-like receptor 1/2 (TLR1/2) agonist .

HY-147310

CU-CPD107	Toll-like Receptor (TLR)	Infection
CU-CPD107 is a potent, selective toll-like receptor 8 (TLR 8) agonist. CU-CPD107 inhibits TLR8 signaling. CU-CPD107 converts to synergistic agonist activities in the presence of ssRNA and induces TLR8 signaling. CU-CPD107 inhibits proinflammatory factor expression and avoids immune responses in the presence of ssRNA .

HY-150741B

FITC-labeled ODN 2216 sodium	Toll-like Receptor (TLR) Interleukin Related	Inflammation/Immunology
FITC-labeled ODN 2216 (sodium) is a human-specific *TLR9* (toll-like receptor 9) ligand or agonist. FITC-labeled ODN 2216 (sodium) can be used to evaluate CpG ODN cellular uptake and localization by confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.

HY-139575

Guretolimod DSP-0509	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
Guretolimod (DSP-0509) is a **Toll-like receptor 7 (TLR7)** agonist .

HY-135811

Desethyl chloroquine 2 Publications Verification	Parasite Toll-like Receptor (TLR) Autophagy	Infection
Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and **toll-like receptors (TLRs)**. Desethyl chloroquine possesses antiplasmodic activity .

製品番号	製品名

HY-L172

Immunopotentiator Compound Library

140 compounds

Immunity refers to the ability of the body to resist the invasion of pathogenic microorganisms and resist a variety of diseases. Immunocompromised will inevitably lead to a series of diseases. Immunopotentiator are a class of compounds that enhance immune function and induce immune response. Immunopotentiator can activate the proliferation and differentiation of one or more kinds of immune active cells in the body, promote the secretion of lymphocytes, and then enhance the immune function of the body. Immunopotentiator are mainly used in the treatment of tumors, infectious diseases and immunodeficiency diseases. In addition, immunopotentiator are often used as adjuvants in combination with vaccine antigens to enhance the immunogenicity of vaccines.

MCE designs a unique collection of 140 compounds with definite or potential Immunopotentiating effect, mainly targeting the NOD-like Receptor (NLR), Toll-like Receptor (TLR), NF-κB, etc. It is an effective tool for development and research of anti-cancer, anti-infectious diseases and anti-immunodeficiency diseases compounds.

製品番号	製品名	Type

HY-13740G

Resiquimod R848; S28463	蛍光色素
Resiquimod (R848) (GMP) is Resiquimod (HY-13740) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist. Resiquimod (GMP) can induce human mMDSC to mature into inflammatory macrophages .

HY-107202GL

Polyinosinic-polycytidylic acid (GMP Like)

Poly(I:C) (GMP like)

蛍光色素

Polyinosinic-polycytidylic acid (Poly(I:C)) (GMP Like) is the GMP Like class Polyinosinic-polycytidylic acid (HY-107202), and can be used as pharmaceutical excipients. Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis .

HY-111582G

BBIQ (GMP)	蛍光色素
BBIQ (GMP) is BBIQ (HY-111582) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. BBIQ is a potent and selectively **toll-like receptor 7 (TLR7) agonist with an EC₅₀** of  59.1 nM. BBIQ is a powerful vaccine adjuvant that enhances innate immune responses .

製品番号	製品名	Type

HY-13740G

Resiquimod R848; S28463	生化学アッセイ試薬
Resiquimod (R848) (GMP) is Resiquimod (HY-13740) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist. Resiquimod (GMP) can induce human mMDSC to mature into inflammatory macrophages .

HY-142980

DOPG

Dioleoylphosphatidylglycerol

生化学アッセイ試薬

DOPG (Dioleoylphosphatidylglycerol) is a negatively charged phosphatidylglycerol phospholipid. DOPG is abundant in prokaryotic cell membranes and mitochondria, and has a low phase transition temperature and a tendency to form stable vesicles. DOPG inhibits the production of inflammatory mediators in macrophages in response to heat shock protein B4 (HSPB4)-activated toll-like receptor 2 (TLR2). DOPG is applicable to studies of membrane biology, drug-membrane interactions (especially in systems targeting negatively charged membranes), construction of drug delivery carriers, as well as research on sterile corneal inflammation and wound healing promotion .

HY-D1056H

Lipopolysaccharides, from S. marcescens

1 Publications Verification

LPS, from Serratia marcescens

生化学アッセイ試薬

Lipopolysaccharides, from S. marcescens (Serratia marcescens) are lipopolysaccharide endotoxins and TLR-4 activators derived from Serratia marcescens, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from S. marcescens exhibit a typical three-part structure: O-antigen (O-antigen), core oligosaccharide (core oligosaccharide), and lipid A (Lipid A). Lipopolysaccharides, from S. marcescens induce NF-κB activation in mouse cells via Toll-like receptor (TLR4)/MD-2. The lipopolysaccharides of S. marcescens can induce apoptosis in host immune cells, thereby suppressing the host's innate immunity .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

HY-107202GL

Polyinosinic-polycytidylic acid (GMP Like)

Poly(I:C) (GMP like)

生化学アッセイ試薬

HY-111582G

BBIQ (GMP)	生化学アッセイ試薬
BBIQ (GMP) is BBIQ (HY-111582) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. BBIQ is a potent and selectively **toll-like receptor 7 (TLR7) agonist with an EC₅₀** of  59.1 nM. BBIQ is a powerful vaccine adjuvant that enhances innate immune responses .

製品番号	製品名	Target	研究分野

HY-P1180A

Pam3CSK4 TFA Maximum Cited Publications 19 Publications Verification Pam3Cys-Ser-(Lys)4 TFA	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC₅₀ of 0.47 ng/mL for human TLR1/2 .

HY-P2036A

FSL-1 TFA 4 Publications Verification	Toll-like Receptor (TLR) MMP HSV Antibiotic	Infection
FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection . FSL-1 TFA induces MMP-9 production through *TLR2* and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells .

HY-P2036

FSL-1 4 Publications Verification	Toll-like Receptor (TLR) Antibiotic	Infection
FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection .

HY-P1180

Pam3CSK4 Pam3Cys-Ser-(Lys)4	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC₅₀ of 0.47 ng/mL for human TLR1/2 .

HY-P10208A

RKH acetate 1 Publications Verification	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
RKH acetate exerts protective effects against sepsis-induced death and organ damage. RKH acetate can directly bind to **Toll-like receptor** 4 (TLR4) and block TLR4 signal transduction in immune cells .

HY-P10586A

Macrophage-activating lipopeptide 2 TFA MALP-2 TFA	Toll-like Receptor (TLR) NO Synthase	Cardiovascular Disease Metabolic Disease
Macrophage-activating lipopeptide 2 TFA is an agonist of Toll like receptors *TLR-2/TLR-6. Macrophage-activating lipopeptide-2 enhances endothelial nitric oxide synthase (eNOS*) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 enhances endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL) .

HY-P1405

Pam3CSK4-Biotin Pam3Cys-Ser-(Lys)4-Biotin	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4-Biotin is biotinylated Pam3CSK4. Pam3CSK4-Biotin is a Toll-like receptor 1/2 (TLR1/2) agonist .

HY-P10586

Macrophage-activating lipopeptide 2 MALP-2	Toll-like Receptor (TLR) NO Synthase	Cardiovascular Disease
Macrophage-activating lipopeptide 2 (MALP-2) is an agonist of Toll like receptors *TLR-2/TLR-6. Macrophage-activating lipopeptide-2 can enhance endothelial nitric oxide synthase (eNOS*) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 can enhance endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL) .

HY-P1405A

Pam3CSK4-Biotin TFA Pam3Cys-Ser-(Lys)4-Biotin TFA	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4-Biotin (Pam3Cys-Ser-(Lys)4-Biotin) TFA is biotinylated Pam3CSK4. Pam3CSK4-Biotin TFA is a Toll-like receptor 1/2 (TLR1/2) agonist .

製品番号	製品名	Category	Target	構造式

HY-113134

25-Hydroxycholesterol Maximum Cited Publications 28 Publications Verification 25-OHC	Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Endogenous Metabolite
25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC₅₀≈65 nM) and selective suppressor of IgA production by B cells.

HY-N6612

D-Glucuronic acid 1 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite Toll-like Receptor (TLR)
D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers, and its derivatives also possess anti-tumor activity .

HY-N6612R

D-Glucuronic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Toll-like Receptor (TLR)
D-Glucuronic acid (Standard) is the analytical standard of D-Glucuronic acid. This product is intended for research and analytical applications. D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity .

HY-N2055

Kaempferol 3-O-sophoroside	Panax ginseng C. A. Meyer Flavonols Structural Classification Classification of Application Fields Plants Flavonoids other families Phenols Polyphenols Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	Toll-like Receptor (TLR) NF-κB TNF Receptor AMPK
Kaempferol 3-O-sophoroside is an orally active derivative of Kaempferol. It exhibits anti-inflammatory, analgesic, and antidepressant effects. Kaempferol 3-O-sophoroside is an inhibitor of the cell surface receptor toll-like receptor *(TLR) 2/4* for High mobility group box 1 (HMGB1), and it also exerts anti-inflammatory effects by blocking the activation of NF-κB expression and the production of TNF-α. Kaempferol 3-O-sophoroside promotes the production of brain-derived neurotrophic factor (BDNF) and enhances autophagy by binding to AMP-activated protein kinase (AMPK), thereby exerting antidepressant effects. Kaempferol 3-O-sophoroside holds promise for research in the fields of inflammation and neurodegenerative diseases .

HY-N14039

Pinus pinaster bark extract	天然物 Pinaceae Pinus pinaster. Plants Source Classification	Toll-like Receptor (TLR) Interleukin Related
Pinus pinaster bark extract is extracted from the bark of pine bark with antioxidant, anti-inflammatory and neuroprotective effects. Pinus pinaster bark extract increases **toll-like receptor (TLR) activity, inducing production of IL-10** .

HY-N6612A

D-Glucuronic acid sodium salt monohydrate 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Toll-like Receptor (TLR)
D-Glucuronic acid sodium salt monohydrate is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid sodium salt monohydrate activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid sodium salt monohydrate and its derivative glucurono-lactone can serve as liver detoxifiers, and its derivatives also possess anti-tumor activity .

HY-113134R

25-Hydroxycholesterol (Standard) 25-OHC (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Endogenous Metabolite Reference Standards
25-Hydroxycholesterol (Standard) is the analytical standard of 25-Hydroxycholesterol. This product is intended for research and analytical applications. 25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

HY-N11768

4-Methoxylonchocarpin	Monophenols Phenols Plants Moraceae Dorstenia mannii Hook.f. Source Classification	NF-κB Interleukin Related Toll-like Receptor (TLR)
4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to **Toll-like Receptor (TLR) TLR4 to inhibit NF-κB** activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model .

製品番号	製品名	構造式

HY-113134S

25-Hydroxycholesterol-d6
25-Hydroxycholesterol-d₆ (25-OHC-d₆) is the deuterium labeled 25-Hydroxycholesterol. 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC₅₀≈65 nM) and selective suppressor of IgA production by B cells .

HY-13740S

Resiquimod-d5 1 Publications Verification
Resiquimod-d₅ is deuterium labeled Resiquimod. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α .

HY-17589AS

Chloroquine-d5 1 Publications Verification
Chloroquine-d₅ is deuterium labeled Chloroquine (HY-17589A). Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM) .

HY-17589S1

Chloroquine-d4 phosphate

Chloroquine-d₄ (phosphate) is the deuterium labeled Chloroquine phosphate. Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM) .

HY-W031727S

Hydroxychloroquine-d4-1 sulfate
Hydroxychloroquine-d₄-1 (sulfate) is the deuterium labeled Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro .

HY-B1370S

Hydroxychloroquine-d4 sulfate
Hydroxychloroquine-d₄ (sulfate) is the deuterium labeled Hydroxychloroquine sulfate. Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro .

HY-17589S

Chloroquine-d5 diphosphate

Chloroquine-d₅ (diphosphate) is the deuterium labeled Chloroquine (phosphate). Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM) .

HY-W031727S1

Hydroxychloroquine-d5
Hydroxychloroquine-d₅ is the deuterium labeled Hydroxychloroquine . Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro .

HY-B0180S1

Imiquimod-d9
Imiquimod-d₉ is deuterium labeled Imiquimod. Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19 .

HY-B0180S

Imiquimod-d6
Imiquimod-d₆ is the deuterium labeled Imiquimod. Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19 .

HY-135811S

Desethyl chloroquine-d4
Desethyl chloroquine-d₄ is the deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity .

HY-135811S1

Desethyl chloroquine-d5
Desethyl chloroquine-d₅ is deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity .

HY-W777545

4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol-d4
4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol-d₄ is the deuterium labeled Hydroxychloroquine Impurity E (HY-131262). Hydroxychloroquine Impurity E is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro .

HY-B0180S2

Imiquimod-d7
Imiquimod-d₇ (R 837-d₇) is deuterium labeled Imiquimod. Imiquimod (R 837), an immune response modifier, is a selective **toll like receptor 7 (TLR7)** agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19 .

製品番号	製品名		Classification

HY-152684

2′-O-2-Propyn-1-ylguanosine		Alkynes
2′-O-2-Propyn-1-ylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** . 2′-O-2-Propyn-1-ylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-152478

3’-β-C-Ethynylguanosine		Alkynes
3’-β-C-Ethynylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** . 3’-β-C-Ethynylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-154361

TLR7 agonist 13		Alkynes
TLR7 agonist 13 is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** . TLR7 agonist 13 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-154349

N2-iso-Butyroyl-2’-O-propargylguanosine		Alkynes
N2-iso-Butyroyl-2’-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** . N2-iso-Butyroyl-2’-O-propargylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

製品番号	製品名		Classification

HY-111582

BBIQ		Adjuvant
BBIQ is a imidazoquinoline compound and a potent and selectively **toll-like receptor 7 (TLR7) agonist with an EC₅₀** of 59.1 nM for human TLR7. BBIQ is a powerful vaccine adjuvant that enhances innate immune responses .

HY-150736

ODN 20844 1 Publications Verification		CpG ODNs
ODN 20844, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a *TLR7* and *TLR9* (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 20844 disrupts TLR7- and TLR9-mediated immune cell immune responses. ODN 20844 sequence: 5'-TCCTGGCGc7GGGAAGT-3' .

HY-150217A

CpG ODN 10101 sodium 2 Publications Verification ODN 10101 sodium		CpG ODNs
CpG ODN 10101 sodium, a synthetic oligodeoxynucleotide (ODN), is a **toll-like receptor 9 (TLR9) agonist. CpG ODN 10101 sodium is a potent inducer of cytokine/chemokine expression ex vivo when used in combination with HH2(VQLRIRVAVIRA-NH2). CpG ODN 10101 sodium induces IFN- secretion from dendritic cells (DCs) and stimulates B-cells.CpG ODN 10101 sodium has antiviral and immunomodulatory properties that can influence chronic infection with HCV** .

HY-142980

DOPG Dioleoylphosphatidylglycerol		Phospholipids
DOPG (Dioleoylphosphatidylglycerol) is a negatively charged phosphatidylglycerol phospholipid. DOPG is abundant in prokaryotic cell membranes and mitochondria, and has a low phase transition temperature and a tendency to form stable vesicles. DOPG inhibits the production of inflammatory mediators in macrophages in response to heat shock protein B4 (HSPB4)-activated toll-like receptor 2 (TLR2). DOPG is applicable to studies of membrane biology, drug-membrane interactions (especially in systems targeting negatively charged membranes), construction of drug delivery carriers, as well as research on sterile corneal inflammation and wound healing promotion .

HY-150746

ODN 24991		CpG ODNs
ODN 24991, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a *TLR3, TLR7* and *TLR9* (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 24991 disrupts TLR3-, TLR7- and TLR9-mediated immune cell immune responses. ODN 24991 sequence: 5'-C-C-T-G-G-C-c7rGm-G-G-G-3' .

HY-154484

3’-O-Me-G(iBu)-2’-phosphoramidite		Phosphoramidites Guanine
3’-O-Me-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-152684

2′-O-2-Propyn-1-ylguanosine		Nucleoside Analogs Guanosine
2′-O-2-Propyn-1-ylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** . 2′-O-2-Propyn-1-ylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-177617

Bazlitoran IMO-8400		CpG ODNs
Bazlitoran (IMO-8400) is an oligonucleotide-based *TLR7/8/9* antagonist. Bazlitoran blocks the activation of Toll-like receptors 7, 8, and 9. Bazlitoran inhibits cytokine responses mediated by Toll-like receptors 7, 8, and 9. Bazlitoran is associated with injection site reactions. Bazlitoran improves moderate-to-severe plaque psoriasis .

HY-148511A

Vidutolimod sodium CMP-001 sodium		CpG ODNs
Vidutolimod sodium is a CpG-A oligodeoxynucleotide. Vidutolimod sodium is a **Toll-like receptor 9 (TLR9)** agonist, which activates plasmacytoid dendritic cells (pDCs) and triggers interferon alpha (IFNα) release, leading to a cascade of anti-tumor immune effects.

HY-150736A

ODN 20844 sodium 1 Publications Verification		CpG ODNs
ODN 20844 sodium, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a *TLR7* and *TLR9* (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 20844 sodium disrupts TLR7- and TLR9-mediated immune cell immune responses. ODN 20844 sequence: 5'-TCCTGGCGc7GGGAAGT-3' .

HY-150734A

ODN 2007 sodium		CpG ODNs
ODN 2007 sodium, a class B CpG ODN (oligodeoxynucleotide), is a Toll-like receptor (TLR) ligand. ODN 2007 sodium can be used as an immunomodulator, vaccine adjuvant, and enhance immune responses in mammals, fish, and humans. ODN 2007 sequence: 5'-TCGTCGTTGTCGTTTTGTCGTT-3' .

HY-150746A

ODN 24991 sodium		CpG ODNs
ODN 24991 sodium, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a *TLR3, TLR7* and *TLR9* (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 24991 sodium disrupts TLR3-, TLR7- and TLR9-mediated immune cell immune responses. ODN 24991 sequence: 5'-C-C-T-G-G-C-c7rGm-G-G-G-3' .

HY-177617A

Bazlitoran sodium IMO-8400 sodium		CpG ODNs
Bazlitoran sodium (IMO-8400 sodium) is an oligonucleotide-based *TLR7/8/9* antagonist. Bazlitoran sodium blocks the activation of Toll-like receptors 7, 8, and 9. Bazlitoran sodium inhibits cytokine responses mediated by Toll-like receptors 7, 8, and 9. Bazlitoran sodium is associated with injection site reactions. Bazlitoran sodium improves moderate-to-severe plaque psoriasis .

HY-150741B

FITC-labeled ODN 2216 sodium		CpG ODNs
FITC-labeled ODN 2216 (sodium) is a human-specific *TLR9* (toll-like receptor 9) ligand or agonist. FITC-labeled ODN 2216 (sodium) can be used to evaluate CpG ODN cellular uptake and localization by confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.

HY-152493

3’-O-(2-Methoxyethyl)guanosine		Nucleoside Analogs Guanosine
3’-O-(2-Methoxyethyl)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-150741A

Biotin-labeled ODN 2216 sodium		CpG ODNs
Biotin-labeled ODN 2216 (sodium) is a human-specific *TLR9* (toll-like receptor 9) ligand or agonist. Biotin-labeled ODN 2216 (sodium) can be used to evaluate CpG ODN cellular uptake and localization using a biotin detection system and light microscopy.

HY-150734

ODN 2007		CpG ODNs
ODN 2007, a class B CpG ODN (oligodeoxynucleotide), is a Toll-like receptor (TLR) ligand. ODN 2007 can be used as an immunomodulator, vaccine adjuvant, and enhance immune responses in mammals, fish, and humans. ODN 2007 sequence: 5'-TCGTCGTTGTCGTTTTGTCGTT-3' .

HY-154332

8-(Phenylmethoxy)guanosine		Nucleoside Analogs Guanosine
8-(Phenylmethoxy)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-152430

8-Hydroxymethyl guanosine		Nucleoside Analogs Guanosine
8-Hydroxymethyl guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-152547

N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine		Nucleoside Analogs Guanosine
N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-154464

N2-iso-Butyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine		Phosphoramidites Guanine
N2-iso-Butyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-152478

3’-β-C-Ethynylguanosine		Nucleoside Analogs Guanosine
3’-β-C-Ethynylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** . 3’-β-C-Ethynylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-154549

3’-O-MOE-G(iBu)-2’-phosphoramidite		Phosphoramidites Guanine
3’-O-MOE-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-152993

2′-Deoxy-N-(2-furanylmethyl)guanosine		Nucleoside Analogs Guanosine
2′-Deoxy-N-(2-furanylmethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-154351

N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite		Phosphoramidites Guanine
N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-174522

Human TLR6 mRNA		mRNA
Human TLR6 mRNA encodes the human toll like receptor 6 (TLR6) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR6 interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins.

HY-174527

Human TLR10 mRNA		mRNA
Human TLR10 mRNA encodes the human toll like receptor 10 (TLR10) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR10 participates in the innate immune response to microbial agents.

HY-174521

Human TLR7 mRNA		mRNA
Human TLR7 mRNA encodes the human toll like receptor 7 (TLR7) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells.

HY-174523

Human TLR5 mRNA		mRNA
Human TLR5 mRNA encodes the human toll like receptor 5 (TLR5) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR5 recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes.

HY-152610

3′-C-Methylguanosine		Nucleoside Analogs Guanosine
3′-C-Methylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-152517

8-(Methylthio)guanosine		Nucleoside Analogs Guanosine
8-(Methylthio)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-154111

8-(N-Boc-aminomethyl)guanosine		Nucleoside Analogs Guanosine
8-(N-Boc-aminomethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-152673

9-(β-D-Xylofuranosyl)guanine		Nucleoside Analogs Guanosine
9-(β-D-Xylofuranosyl)guanine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-154506

N2-Phenoxyacetylguanosine		Nucleoside Analogs Guanosine
N2-Phenoxyacetylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-152742

8-(N,N-Dimethylaminomethyl)guanosine		Nucleoside Analogs Guanosine
8-(N,N-Dimethylaminomethyl)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-152652

5’(R)-C-Methylguanosine		Nucleoside Analogs Guanosine
5’(R)-C-Methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-154336

N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine		Nucleoside Analogs Guanosine
N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-152991

6-Deoxo-8-oxo-3’-deoxy-guanosine		Nucleoside Analogs Guanosine
2′-Deoxy-N-(2-furanylmethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-177642

Litenimod Li28		CpG ODNs
Litenimod is potent type B agonist of toll Like receptor 9 (TLR9), triggering both innate and adaptive immune response.

HY-177642A

Litenimod sodium Li28 sodium sodium		CpG ODNs
Litenimod sodium is potent type B agonist of toll Like receptor 9 (TLR9), triggering both innate and adaptive immune response.

HY-154482

N2-iso-Butyroyl-3’-O-methylguanosine		Nucleoside Analogs Guanosine
N2-iso-Butyroyl-3’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-154448

3,5-Bis-O-(2,4-dichlorobenzyl)guanosine		Nucleoside Analogs Guanosine
3,5-Bis-O-(2,4-dichlorobenzyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-152988

N2-iso-Butyroyl-7'-O-DMT-morpholinoguanine		Phosphoramidites Guanine
N2-iso-Butyroyl-7'-O-DMT-morpholinoguanine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-152992

7-Cyano-7-deaza-2'-deoxy guanosine		Nucleoside Analogs Guanosine
7-Cyano-7-deaza-2'-deoxy guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-152797

N4-Desmethyl-N5-Methyl wyosine		Nucleoside Analogs
N4-Desmethyl-N5-Methyl wyosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-154547

N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine		Nucleoside Analogs Guanosine
N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-152545

N1,N2-Dimethyl-2’-O-methylguanosine		Nucleoside Analogs Guanosine
N1,N2-Dimethyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-154350

5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine		Phosphoramidites Guanine
5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-154606

2'-F-2'-ara-N2-ibu-dG Phosphoramidite		Phosphoramidites Guanine
2'-F-2'-ara-N2-ibu-dG Phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

HY-154548

N2-iso-Butyroyl-5’-O-DMT-3’-O-(methoxyethyl)guanosine		Phosphoramidites Guanine
N2-iso-Butyroyl-5’-O-DMT-3’-O-(methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of **Toll-like receptor 7 (TLR7)** .

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