2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Guretolimod hydrochloride

Guretolimod hydrochloride  (Synonyms: DSP-0509 hydrochloride)

Cat. No.: HY-139575A Purity: 98.67%
COA Handling Instructions

Molarity Calculator

Guretolimod hydrochloride is a Toll-like receptor 7 (TLR7) agonist.

For research use only. We do not sell to patients.

Guretolimod hydrochloride Chemical Structure

Guretolimod hydrochloride Chemical Structure

Size Price Stock Quantity
5 mg USD 590 In-stock
10 mg USD 950 In-stock
25 mg USD 1900 In-stock
50 mg USD 3060 In-stock
100 mg USD 4900 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Guretolimod hydrochloride:

Guretolimod hydrochloride Related Antibodies

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Description

Guretolimod hydrochloride is a Toll-like receptor 7 (TLR7) agonist[1].

IC50 & Target

TLR7[1]
Clinical Trial
Molecular Weight

550.01

Formula

C24H35ClF3N5O4
Appearance

Solid

Color

Off-white to light yellow

SMILES

CCC[C@@H](CCO)NC1=NC(N)=NC(C)=C1CC2=C(C=C(C=C2)CN(CC(O)=O)CC(F)(F)F)OC.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (181.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8181 mL 9.0907 mL 18.1815 mL
5 mM 0.3636 mL 1.8181 mL 3.6363 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.67%

COA (251 KB) HNMR (277 KB) RP-HPLC (301 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8181 mL 9.0907 mL 18.1815 mL 45.4537 mL
5 mM 0.3636 mL 1.8181 mL 3.6363 mL 9.0907 mL
10 mM 0.1818 mL 0.9091 mL 1.8181 mL 4.5454 mL
15 mM 0.1212 mL 0.6060 mL 1.2121 mL 3.0302 mL
20 mM 0.0909 mL 0.4545 mL 0.9091 mL 2.2727 mL
25 mM 0.0727 mL 0.3636 mL 0.7273 mL 1.8181 mL
30 mM 0.0606 mL 0.3030 mL 0.6060 mL 1.5151 mL
40 mM 0.0455 mL 0.2273 mL 0.4545 mL 1.1363 mL
50 mM 0.0364 mL 0.1818 mL 0.3636 mL 0.9091 mL
60 mM 0.0303 mL 0.1515 mL 0.3030 mL 0.7576 mL
80 mM 0.0227 mL 0.1136 mL 0.2273 mL 0.5682 mL
100 mM 0.0182 mL 0.0909 mL 0.1818 mL 0.4545 mL
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Guretolimod hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GuretolimodDSP-0509DSP0509DSP 0509Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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