1. Immunology/Inflammation
    Anti-infection
  2. Toll-like Receptor (TLR)
    Influenza Virus
  3. 3M-011

3M-011 

Cat. No.: HY-121496
Handling Instructions

3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer. 3M-011 significantly inhibits H3N2 influenza viral replication in the nasal cavity. 3M-011 is also a potent adjuvant to radiotherapy that induces local and profound systemic immune responses during radiotherapy. 3M-011 strongly has antitumor action.

For research use only. We do not sell to patients.

3M-011 Chemical Structure

3M-011 Chemical Structure

CAS No. : 642473-62-9

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Description

3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer. 3M-011 significantly inhibits H3N2 influenza viral replication in the nasal cavity. 3M-011 is also a potent adjuvant to radiotherapy that induces local and profound systemic immune responses during radiotherapy. 3M-011 strongly has antitumor action[1][2][3].

IC50 & Target[1][2]

TLR7

 

TLR8

 

H3N2 influenza viral

 

In Vitro

3M-011 (0-100 μg/mL; 24 hours; B16-F10 melanoma cells) treatment can decrease B16-F10 melanoma cell counts[1].
3M-011 potentiates natural killer (NK) cells cytotoxicity[1].
The NF-κB reporter is stably integrated into HEK-293 cells that are subsequently transiently transfected with human or mouse TLR7 or TLR8. With all the TLRs tested, except mouse TLR8, stimulation with 3M-011 results in a dose-dependent induction of NF-κB-controlled luciferase activity. 3M-011 in humans activates both TLR7 and TLR8, whereas in mice, 3M011 activates only TLR7 and not TLR8[1].

Cell Cytotoxicity Assay[1]

Cell Line: B16-F10 melanoma cells
Concentration: 0 μg/mL, 1 μg/mL, 10 μg/mL, 33 μg/mL, 67 μg/mL, 100 μg/mL
Incubation Time: 24 hours
Result: Decreased B16-F10 melanoma cell counts.
In Vivo

3M-011 (1 mg/kg; intravenous injection; every other day with six doses; female scid/NOD mice) treatment shows antitumor effects in scid/NOD mice bearing B16-F10 cells[1].
Wild-type C57BL/6 mice are injected subcutaneously with different doses of 3M-011 (0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, or 10 mg/kg). 3M-011 induces a dose-dependent increase in serum concentrations of both TNF-α and IFN-α/β[1].

Animal Model: Female scid/NOD mice (8-12-week-old) injected with B16-F10 cells[1]
Dosage: 1 mg/kg
Administration: Intravenous injection; every other day with six doses
Result: Had antitumor effects in scid/NOD mice bearing B16-F10 cells.
Molecular Weight

391.49

Formula

C₁₈H₂₅N₅O₃S

CAS No.

642473-62-9

SMILES

CS(=O)(NC(C)(C)CN1C(COCC)=NC2=C1C3=CC=CC=C3N=C2N)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

3M-011Toll-like Receptor (TLR)Influenza VirusImmunotherapyTLR7TLR8antitumorIFN-γIFN-αcytokineH3N2replicationadjuvantInhibitorinhibitorinhibit

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3M-011
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