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Cat. No.: HY-147310

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CU-CPD107

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Based on 1 Customer Validation

CU-CPD107 is a potent, selective toll-like receptor 8 (TLR 8) agonist. CU-CPD107 inhibits TLR8 signaling. CU-CPD107 converts to synergistic agonist activities in the presence of ssRNA and induces TLR8 signaling. CU-CPD107 inhibits proinflammatory factor expression and avoids immune responses in the presence of ssRNA.

For research use only. We do not sell to patients.

Purity: 98.07%
CAS No.: 2573912-32-8
Formula: C₁₆H₂₁IN₂O₂
Molecular Weight:400.25

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

CU-CPD107 Chemical Structure

CAS No.: 2573912-32-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

All Toll-like Receptor (TLR) Isoforms :

In Vitro

CU-CPD107 (HEK-Blue hTLR8 cells) inhibits R848-induced signaling with an IC₅₀ value of 13.7 μM^[1].
CU-CPD107 (0-100 μM; HEK-Blue hTLR8 cells) converts to an agonist in the presence of ssRNA^[1].
CU-CPD107 (100 μM; HEK-Blue hTLR8 cells) decreases IFN-β, TNF-α, IL-1β, IL-6 and IL-8 mRNA expression levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2573912-32-8
Appearance Solid
Molecular Weight 400.25
Formula C₁₆H₂₁IN₂O₂
Color White to off-white
SMILES

IC1=C(C2=CC=CC=C2)N(CC(C)(C)O)C(COCC)=N1
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (312.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4984 mL

12.4922 mL

24.9844 mL

5 mM

0.4997 mL

2.4984 mL

4.9969 mL

10 mM

0.2498 mL

1.2492 mL

2.4984 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang Y, et, al. Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists. Nat Commun. 2021 Jul 16;12(1):4351. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4984 mL	12.4922 mL	24.9844 mL	62.4610 mL
	5 mM	0.4997 mL	2.4984 mL	4.9969 mL	12.4922 mL
	10 mM	0.2498 mL	1.2492 mL	2.4984 mL	6.2461 mL
	15 mM	0.1666 mL	0.8328 mL	1.6656 mL	4.1641 mL
	20 mM	0.1249 mL	0.6246 mL	1.2492 mL	3.1230 mL
	25 mM	0.0999 mL	0.4997 mL	0.9994 mL	2.4984 mL
	30 mM	0.0833 mL	0.4164 mL	0.8328 mL	2.0820 mL
	40 mM	0.0625 mL	0.3123 mL	0.6246 mL	1.5615 mL
	50 mM	0.0500 mL	0.2498 mL	0.4997 mL	1.2492 mL
	60 mM	0.0416 mL	0.2082 mL	0.4164 mL	1.0410 mL
	80 mM	0.0312 mL	0.1562 mL	0.3123 mL	0.7808 mL
	100 mM	0.0250 mL	0.1249 mL	0.2498 mL	0.6246 mL

Keywords

100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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CU-CPD107

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Small Molecule Immuno-Oncology Compound Library

Antioxidant Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Pyroptosis Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Highly Selective Activators Library

Immunopotentiator Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Pattern Recognition Receptors Library

All Toll-like Receptor (TLR) Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

CU-CPD107

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Small Molecule Immuno-Oncology Compound Library

Antioxidant Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Pyroptosis Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Highly Selective Activators Library

Immunopotentiator Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Pattern Recognition Receptors Library

All Toll-like Receptor (TLR) Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

CU-CPD107 Related Classifications

Cat. No.: HY-147310