CU-CPD107 

CU-CPD107 is a potent, selective toll-like receptor 8 (TLR 8) agonist. CU-CPD107 inhibits TLR8 signaling. CU-CPD107 converts to synergistic agonist activities in the presence of ssRNA and induces TLR8 signaling. CU-CPD107 inhibits proinflammatory factor expression and avoids immune responses in the presence of ssRNA^[1].

CU-CPD107 (HEK-Blue hTLR8 cells) inhibits R848-induced signaling with an IC₅₀ value of 13.7 µM^[1].
CU-CPD107 (0-100 µM; HEK-Blue hTLR8 cells) converts to an agonist in the presence of ssRNA^[1].
CU-CPD107 (100 µM; HEK-Blue hTLR8 cells) decreases IFN-β, TNF-α, IL-1β, IL-6 and IL-8 mRNA expression levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

400.25

C₁₆H₂₁IN₂O₂

2573912-32-8

IC1=C(C2=CC=CC=C2)N(CC(C)(C)O)C(COCC)=N1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yang Y, et, al. Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists. Nat Commun. 2021 Jul 16;12(1):4351.  [Content Brief]