TLR7/8 agonist 8
Based on 1 Customer Validation
TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade.
For research use only. We do not sell to patients.
- Purity: 98.69%
- CAS No.: 2649170-16-9
- Formula: C24H30N6O
- Molecular Weight:418.53
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
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TLR7 27 nM (EC50) |
TLR8 12 nM (EC50) |
Chemical Information
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CAS No. 2649170-16-9
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Appearance Solid
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Molecular Weight 418.53
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Formula C24H30N6O
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Color White to off-white
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SMILES
CCCCNC1=C2N=C(CC3=CC=C(CN4CC5(C4)COC5)C=C3)C=CC2=NC(N)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)