2649170-16-9
2649170-16-9
Chemical Structure
TLR7/8 agonist 8
- CAS No.: 2649170-16-9
- Formula:C24H30N6O
- Molecular Weight:418.53
IUPAC Name: 6-(4-((2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl)benzyl)-N4-butylpyrido[3,2-d]pyrimidine-2,4-diamine
InChIKey: MJIGXQDERFISLK-UHFFFAOYSA-N
SMILES: CCCCNC1=C2N=C(CC3=CC=C(CN4CC5(C4)COC5)C=C3)C=CC2=NC(N)=N1
Biological Activity: TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TLR7/8 agonist 8 | 98.69% | TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade. | ||||||||||||||||||||
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References
Keywords
