1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. Telratolimod

Telratolimod (Synonyms: MEDI 9197; 3M 052)

Cat. No.: HY-109104 Purity: >98.0%
Handling Instructions

Telratolimod is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.

For research use only. We do not sell to patients.

Telratolimod Chemical Structure

Telratolimod Chemical Structure

CAS No. : 1359993-59-1

Size Price Stock Quantity
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3300 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Telratolimod is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.

IC50 & Target

TLR7/8[1]

In Vitro

Telratolimod (3M-052) is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity[1].

In Vivo

Telratolimod (50 μg) inhibits the tumor volume, and more potently blocks tumor gowth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs survival of mice bearing large tumors[1].

Clinical Trial
Molecular Weight

593.89

Formula

C₃₆H₅₉N₅O₂

CAS No.

1359993-59-1

SMILES

NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3OCCCCNC(CCCCCCCCCCCCCCCCC)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (8.42 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6838 mL 8.4191 mL 16.8381 mL
5 mM 0.3368 mL 1.6838 mL 3.3676 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.5 mg/mL (0.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 0.5 mg/mL (0.84 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (0.84 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Telratolimod
Cat. No.:
HY-109104
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