1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. Telratolimod

Telratolimod (Synonyms: MEDI9197; 3M-052)

Cat. No.: HY-109104 Purity: 99.04%
Handling Instructions

Telratolimod (MEDI9197) is a potent toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.

For research use only. We do not sell to patients.

Telratolimod Chemical Structure

Telratolimod Chemical Structure

CAS No. : 1359993-59-1

Size Price Stock Quantity
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Telratolimod (MEDI9197) is a potent toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity[1].

IC50 & Target

TLR7/8[1]

In Vitro

Telratolimod (3M-052) is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Telratolimod (50 μg) inhibits the tumor volume, and more potently blocks tumor gowth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs survival of mice bearing large tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

593.89

Formula

C₃₆H₅₉N₅O₂

CAS No.

1359993-59-1

SMILES

NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3OCCCCNC(CCCCCCCCCCCCCCCCC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (8.42 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6838 mL 8.4191 mL 16.8381 mL
5 mM 0.3368 mL 1.6838 mL 3.3676 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.5 mg/mL (0.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 0.5 mg/mL (0.84 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (0.84 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TelratolimodMEDI9197 3M-052MEDI 9197MEDI-9197Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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Product Name:
Telratolimod
Cat. No.:
HY-109104
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