1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. Telratolimod

Telratolimod  (Synonyms: MEDI9197; 3M-052)

Cat. No.: HY-109104 Purity: 98.98%
COA Handling Instructions

Telratolimod (MEDI9197) is a potent toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.

For research use only. We do not sell to patients.

Telratolimod Chemical Structure

Telratolimod Chemical Structure

CAS No. : 1359993-59-1

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 588 In-stock
Solution
10 mM * 1 mL in DMSO USD 588 In-stock
Solid
1 mg USD 214 In-stock
5 mg USD 450 In-stock
10 mg USD 750 In-stock
25 mg USD 1500 In-stock
50 mg USD 2100 In-stock
100 mg USD 3300 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 7 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Telratolimod purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2022 Dec 16;e2206001.  [Abstract]

    Telratolimod (0.2 mg/kg; intratumorally injection; single daily for 3 days) or Telratolimod loaded into the lipid droplets of adipocytes significantly inhibit growth of both original and distant tumor in vivo.

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    • Customer Review

    Description

    Telratolimod (MEDI9197) is a potent toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity[1].

    IC50 & Target

    TLR7

     

    TLR8

     

    In Vitro

    Telratolimod (3M-052) is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Telratolimod (50 μg) inhibits the tumor volume, and more potently blocks tumor gowth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs survival of mice bearing large tumors[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    593.89

    Formula

    C36H59N5O2

    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3OCCCCNC(CCCCCCCCCCCCCCCCC)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 62.5 mg/mL (105.24 mM; Need ultrasonic)

    Ethanol : 50 mg/mL (84.19 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6838 mL 8.4191 mL 16.8381 mL
    5 mM 0.3368 mL 1.6838 mL 3.3676 mL
    10 mM 0.1684 mL 0.8419 mL 1.6838 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% EtOH    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (4.21 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.08 mg/mL (3.50 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: 2.08 mg/mL (3.50 mM); Suspended solution; Need ultrasonic

    • 4.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (3.50 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation
    References
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    Telratolimod Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Inquiry Information

    Product Name:
    Telratolimod
    Cat. No.:
    HY-109104
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